GLORIA

GEOMAR Library Ocean Research Information Access

Ihre E-Mail wurde erfolgreich gesendet. Bitte prüfen Sie Ihren Maileingang.

Leider ist ein Fehler beim E-Mail-Versand aufgetreten. Bitte versuchen Sie es erneut.

Vorgang fortführen?

Exportieren
  • 1
    In: Genetics, Oxford University Press (OUP), Vol. 167, No. 4 ( 2004-08-01), p. 1873-1881
    Kurzfassung: A quantitative trait locus (QTL) for milk fat percentage has been mapped consistently to the centromeric region of bovine chromosome 14 (BTA14). Two independent studies have identified the nonconservative mutation K232A in the acylCoA-diacylglycerol-acyltransferase 1 (DGAT1) gene as likely to be causal for the observed variation. Here we provide evidence for additional genetic variability at the same QTL that is associated with milk fat percentage variation within the German Holstein population. Namely, we show that alleles of the DGAT1 promoter derived from the variable number of tandem repeat (VNTR) polymorphism are associated with milk fat content in animals homozygous for the allele 232A at DGAT1. Our results present another example for more than two trait-associated alleles being involved in a major gene effect on a quantitative trait. The segregation of multiple alleles affecting milk production traits at the QTL on BTA14 has to be considered whenever marker-assisted selection programs are implemented in dairy cattle. Due to the presence of a potential transcription factor binding site in the 18mer element of the VNTR, the variation in the number of tandem repeats of the 18mer element might be causal for the variability in the transcription level of the DGAT1 gene.
    Materialart: Online-Ressource
    ISSN: 1943-2631
    Sprache: Englisch
    Verlag: Oxford University Press (OUP)
    Publikationsdatum: 2004
    ZDB Id: 1477228-0
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 2
    Online-Ressource
    Online-Ressource
    Oxford University Press (OUP) ; 2020
    In:  Journal of Animal Science Vol. 98, No. Supplement_4 ( 2020-11-30), p. 30-31
    In: Journal of Animal Science, Oxford University Press (OUP), Vol. 98, No. Supplement_4 ( 2020-11-30), p. 30-31
    Kurzfassung: Worldwide, dairy cattle breeding companies and farmers face several challenges, including concerns about climatic impact of milk production, increasing scarcity of natural resources and feed, and concerns about animal welfare and health. The recording of accurate and comprehensive phenotypic data for these new issues is important for both management and breeding. Technological developments play a key role in this context. An increasing spectrum of traits with relevance to the breeding goal has become available (e.g. behavioral traits from sensor-derived activity patterns, milk metabolites reflecting the metabolic status, direct or indirect measurements of methane emissions). The biological background and genetic architecture of many of the evolving novel traits as well as their relationship with other traits of interest is not yet well understood, which hinders appropriate implementation in breeding programs. Especially for traits that are difficult or expensive to measure, such as feed intake or methane emissions, phenotypes are scarce. Interdisciplinary research and across-country data pooling can be enormously helpful to ensure a fast progress. Hence, the development of universal guidelines for recording is a crucial step, also with regard to a successful application of genomic selection, which enables the improvement of difficult-to-measure traits by transferring genomic knowledge from estimates within comparatively small reference populations to the population level. Furthermore, some traits (e.g. feed intake) show a lactation-stage specific genetic architecture. This highlights the importance of repeated measurements as well as knowledge on genetic correlations among all relevant traits across days in milk, the latter being an important prerequisite for designing balanced breeding strategies. With more traits, especially more complex traits, increasing data sources and volumes, setting up reasonable breeding goals becomes much more sophisticated and often requires innovative approaches.
    Materialart: Online-Ressource
    ISSN: 0021-8812 , 1525-3163
    Sprache: Englisch
    Verlag: Oxford University Press (OUP)
    Publikationsdatum: 2020
    ZDB Id: 1490550-4
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 3
    Online-Ressource
    Online-Ressource
    Oxford University Press (OUP) ; 2013
    In:  Genetics Vol. 193, No. 2 ( 2013-02-01), p. 431-442
    In: Genetics, Oxford University Press (OUP), Vol. 193, No. 2 ( 2013-02-01), p. 431-442
    Kurzfassung: The estimation of dominance effects requires the availability of direct phenotypes, i.e., genotypes and phenotypes in the same individuals. In dairy cattle, classical QTL mapping approaches are, however, relying on genotyped sires and daughter-based phenotypes like breeding values. Thus, dominance effects cannot be estimated. The number of dairy bulls genotyped for dense genome-wide marker panels is steadily increasing in the context of genomic selection schemes. The availability of genotyped cows is, however, limited. Within the current study, the genotypes of male ancestors were applied to the calculation of genotype probabilities in cows. Together with the cows’ phenotypes, these probabilities were used to estimate dominance effects on a genome-wide scale. The impact of sample size, the depth of pedigree used in deriving genotype probabilities, the linkage disequilibrium between QTL and marker, the fraction of variance explained by the QTL, and the degree of dominance on the power to detect dominance were analyzed in simulation studies. The effect of relatedness among animals on the specificity of detection was addressed. Furthermore, the approach was applied to a real data set comprising 470,000 Holstein cows. To account for relatedness between animals a mixed-model two-step approach was used to adjust phenotypes based on an additive genetic relationship matrix. Thereby, considerable dominance effects were identified for important milk production traits. The approach might serve as a powerful tool to dissect the genetic architecture of performance and functional traits in dairy cattle.
    Materialart: Online-Ressource
    ISSN: 1943-2631
    Sprache: Englisch
    Verlag: Oxford University Press (OUP)
    Publikationsdatum: 2013
    ZDB Id: 1477228-0
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 4
    Online-Ressource
    Online-Ressource
    Oxford University Press (OUP) ; 1996
    In:  Genetics Vol. 143, No. 4 ( 1996-08-01), p. 1831-1842
    In: Genetics, Oxford University Press (OUP), Vol. 143, No. 4 ( 1996-08-01), p. 1831-1842
    Kurzfassung: Information on multiple linked genetic markers was used in a Bayesian method for the statistical mapping of quantitative trait loci (QTL). Bayesian parameter estimation and hypothesis testing were implemented via Markov chain Monte Carlo algorithms. Variables sampled were the augmented data (marker-QTL genotypes, polygenic effects), an indicator variable for linkage or nonlinkage, and the parameters. The parameter vector included allele frequencies at the markers and the QTL, map distances of the markers and the QTL, QTL substitution effect, and polygenic and residual variances. The criterion for QTL detection was the marginal posterior probability of a QTL being located on the chromosome carrying the markers, The method was evaluated empirically by analyzing simulated granddaughter designs consisting of 2000 sons, 20 related sires, and their ancestors.
    Materialart: Online-Ressource
    ISSN: 1943-2631
    Sprache: Englisch
    Verlag: Oxford University Press (OUP)
    Publikationsdatum: 1996
    ZDB Id: 1477228-0
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 5
    Online-Ressource
    Online-Ressource
    Oxford University Press (OUP) ; 2020
    In:  Animal Frontiers Vol. 10, No. 2 ( 2020-04-01), p. 23-28
    In: Animal Frontiers, Oxford University Press (OUP), Vol. 10, No. 2 ( 2020-04-01), p. 23-28
    Materialart: Online-Ressource
    ISSN: 2160-6056 , 2160-6064
    Sprache: Englisch
    Verlag: Oxford University Press (OUP)
    Publikationsdatum: 2020
    ZDB Id: 2628125-9
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 6
    Online-Ressource
    Online-Ressource
    Oxford University Press (OUP) ; 2019
    In:  G3 Genes|Genomes|Genetics Vol. 9, No. 9 ( 2019-09-01), p. 2823-2834
    In: G3 Genes|Genomes|Genetics, Oxford University Press (OUP), Vol. 9, No. 9 ( 2019-09-01), p. 2823-2834
    Kurzfassung: In order to gain insight into the genetic architecture of economically important traits in pigs and to derive suitable genetic markers to improve these traits in breeding programs, many studies have been conducted to map quantitative trait loci. Shortcomings of these studies were low mapping resolution, large confidence intervals for quantitative trait loci-positions and large linkage disequilibrium blocks. Here, we overcome these shortcomings by pooling four large F2 designs to produce smaller linkage disequilibrium blocks and by resequencing the founder generation at high coverage and the F1 generation at low coverage for subsequent imputation of the F2 generation to whole genome sequencing marker density. This lead to the discovery of more than 32 million variants, 8 million of which have not been previously reported. The pooling of the four F2 designs enabled us to perform a joint genome-wide association study, which lead to the identification of numerous significantly associated variant clusters on chromosomes 1, 2, 4, 7, 17 and 18 for the growth and carcass traits average daily gain, back fat thickness, meat fat ratio, and carcass length. We could not only confirm previously reported, but also discovered new quantitative trait loci. As a result, several new candidate genes are discussed, among them BMP2 (bone morphogenetic protein 2), which we recently discovered in a related study. Variant effect prediction revealed that 15 high impact variants for the traits back fat thickness, meat fat ratio and carcass length were among the statistically significantly associated variants.
    Materialart: Online-Ressource
    ISSN: 2160-1836
    Sprache: Englisch
    Verlag: Oxford University Press (OUP)
    Publikationsdatum: 2019
    ZDB Id: 2629978-1
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 7
    In: Genetics, Oxford University Press (OUP), Vol. 149, No. 4 ( 1998-08-01), p. 1959-1973
    Kurzfassung: Quantitative trait loci (QTL) affecting milk production and health of dairy cattle were mapped in a very large Holstein granddaughter design. The analysis included 1794 sons of 14 sires and 206 genetic markers distributed across all 29 autosomes and flanking an estimated 2497 autosomal cM using Kosambi's mapping function. All families were analyzed jointly with least-squares (LS) and variance components (VC) methods. A total of 6 QTL exceeding approximate experiment-wise significance thresholds, 24 QTL exceeding suggestive thresholds, and 34 QTL exceeding chromosome-wise thresholds were identified. Significance thresholds were determined via data permutation (for LS analysis) and chi-square distribution (for VC analysis). The average bootstrap confidence interval for the experiment-wise significant QTL was 48 cM. Some chromosomes harbored QTL affecting several traits, and these were always in coupling phase, defined by consistency with genetic correlations among traits. Chromosome 17 likely harbors 2 QTL affecting milk yield, and some other chromosomes showed some evidence for 2 linked QTL affecting the same trait. In each of these cases, the 2 QTL were in repulsion phase in those families appearing to be heterozygous for both QTL, a finding which supports the build-up of linkage disequilibrium due to selection.
    Materialart: Online-Ressource
    ISSN: 1943-2631
    Sprache: Englisch
    Verlag: Oxford University Press (OUP)
    Publikationsdatum: 1998
    ZDB Id: 1477228-0
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 8
    Online-Ressource
    Online-Ressource
    Oxford University Press (OUP) ; 2005
    In:  Genetics Vol. 171, No. 3 ( 2005-11-01), p. 1207-1217
    In: Genetics, Oxford University Press (OUP), Vol. 171, No. 3 ( 2005-11-01), p. 1207-1217
    Kurzfassung: Anal atresia is a rare and severe disorder in swine occurring with an incidence of 0.1–1.0%. A whole-genome scan based on affected half-sibs was performed to identify susceptibility loci for anal atresia. The analysis included 27 families with a total of 95 animals and 65 affected piglets among them. Animals were genotyped for 126 microsatellite markers distributed across the 18 autosomal porcine chromosomes and the X chromosome, covering an estimated 2080 cM. Single-point and multipoint nonparametric linkage scores were calculated using the computer package ALLEGRO 1.0. Significant linkage results were obtained for chromosomes 1, 3, and 12. Markers on these chromosomes and additionally on chromosomes for which candidate genes have been postulated in previous studies were subjected to the transmission disequilibrium test (TDT). The test statistic exceeded the genomewide significance level for adjacent markers SW1621 (P = 7 × 10−7) and SW1902 (P = 3 × 10−3) on chromosome 1, supporting the results of the linkage analysis. A specific haplotype associated with anal atresia that could prove useful for selection against the disorder was revealed. Suggestive linkage and association were also found for markers S0081 on chromosome 9 and SW957 on chromosome 12.
    Materialart: Online-Ressource
    ISSN: 1943-2631
    Sprache: Englisch
    Verlag: Oxford University Press (OUP)
    Publikationsdatum: 2005
    ZDB Id: 1477228-0
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 9
    Online-Ressource
    Online-Ressource
    Oxford University Press (OUP) ; 2013
    In:  G3 Genes|Genomes|Genetics Vol. 3, No. 7 ( 2013-07-01), p. 1085-1093
    In: G3 Genes|Genomes|Genetics, Oxford University Press (OUP), Vol. 3, No. 7 ( 2013-07-01), p. 1085-1093
    Kurzfassung: Genotype-by-environment interaction (GxE) has been widely reported in dairy cattle. One way to analyze GxE is to apply reaction norm models. The first derivative of a reaction norm is the environmental sensitivity (ES). In the present study we conducted a large-scale, genome-wide association analysis to identify single-nucleotide polymorphisms (SNPs) that affect general production (GP) and ES of milk traits in the German Holstein population. Sire estimates for GP and for ES were calculated from approximately 13 million daughter records by the use of linear reaction norm models. The daughters were offspring from 2297 sires. Sires were genotyped for 54k SNPs. The environment was defined as the average milk energy yield performance of the herds at the time during which the daughter observations were recorded. The sire estimates were used as observations in a genome-wide association analysis, using 1797 sires. Significant SNPs were confirmed in an independent validation set (500 sires of the same population). To separate GxE scaling and other GxE effects, the observations were log-transformed in some analyses. Results from the reaction norm model revealed GxE effects. Numerous significant SNPs were validated for both GP and ES. Many SNPs that affect GP also affect ES. We showed that ES of milk traits is a typical quantitative trait, genetically controlled by many genes with small effects and few genes with larger effect. A log-transformation of the observation resulted in a reduced number of validated SNPs for ES, pointing to genes that not only caused scaling GxE effects. The results will have implications for breeding for robustness in dairy cattle.
    Materialart: Online-Ressource
    ISSN: 2160-1836
    Sprache: Englisch
    Verlag: Oxford University Press (OUP)
    Publikationsdatum: 2013
    ZDB Id: 2629978-1
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
Schließen ⊗
Diese Webseite nutzt Cookies und das Analyse-Tool Matomo. Weitere Informationen finden Sie hier...