Publication Date:
2014-01-08
Description:
Three deep-pore locations, L312, A313, and A316, were identified in a scanning mutagenesis study of the BK (Ca2+-activated, large-conductance K+) channel S6 pore, where single aspartate substitutions led to constitutively open mutant channels (L312D, A313D, and A316D). To understand the mechanisms of the constitutive openness of these mutant channels, we...
Print ISSN:
0027-8424
Electronic ISSN:
1091-6490
Topics:
Biology
,
Medicine
,
Natural Sciences in General
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