ISSN:
1600-0765
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Factors which increase the risk of severe adult jreiodontitis (AP) may also contribute to the success of dental implants. To determine which cytokines may be relevant, levels of interleukin-1α(IL-1α), interleukin-1β(IL-1β), interleukin-1 receptor antagonist (IL-1ra), interleukin-6 (IL-6) and interferon-γ(IFN-γ) mRNA were quantitated in gingival tissue from jreiodontitis patients and healthy controls. Jreiodontitis significantly increased levels of IL-1α, IL-1β, IL-6 and IFN-γ mRNA relative to healthy tissues. IL-1 was selected for further study, as it has inflammatory and bone resorbing projreties. We examined IL-1A(−889) and IL-1B(+3953) alleles in Caucasian patients with AP and early-onset jreiodontitis (EOP), patients with dental implants and healthy individuals. The IL-1B(+3953) polymorphism was associated with AP. This was evident from an increased homozygosity for allele 2 in patients with AP and a decreased heterozygosity in advanced AP patients. IL-1A(−889) and a composite genotype [IL-1A(−889)2 plus IL-1B(+3953)2] showed no association with the incidence of jreiodontitis, disease onset or disease severity. IL-1A(−889), IL-1B(+3953) and the composite genotype also showed no association with failure of dental implants.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1034/j.1600-0765.2002.00651.x
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