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  • 1
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    Krüppel-like factor 8 promotes cancer stem cell-like traits in hepatocellular carcinoma through Wnt/β-catenin signaling (2016)
    Wiley-Blackwell
    Details
    Publication Date: 2016-08-02
    Description: Krüppel-like factor 8 (KLF8) is highly expressed in hepatocellular carcinoma (HCC) and contributes to tumor initiation and progression by promoting HCC cell proliferation and invasion. However, the role of KLF8 in liver cancer stem cells (LCSCs) is not known. In the current study, we investigated the role of KLF8 in LCSCs to determine if KLF8 is a novel marker of these cells. We found that KLF8 was highly expressed in primary HCC tumors, distant migrated tissues, and LCSCs. Patients with high KLF8 expression had a poor prognosis. KLF8 promoted stem cell-like features through activation of the Wnt/β-catenin signaling pathway. Cell apoptosis was significantly increased in HCC cells with knockdown of KLF8 compared with the control cells when treated with the same doses of sorafenib or cisplatin. Taken together, our study shows that KLF8 plays a potent oncogenic role in HCC tumorigenesis by maintaining stem cell-like features through activation of the Wnt/β-catenin signaling pathway and promoting chemoresistance. Thus, targeting KLF8 may provide an effective therapeutic approach to suppress tumorigenicity of HCC. This article is protected by copyright. All rights reserved
    Print ISSN: 0899-1987
    Electronic ISSN: 1098-2744
    Topics: Medicine
    Published by Wiley-Blackwell
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  • 2
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    Sustainability, Vol. 9, Pages 1240: Optimal Environmental Regulation Intensity of Manufacturing Technology Innovation in View of Pollution Heterogeneity (2017)
    MDPI Publishing
    Details
    Publication Date: 2017-07-16
    Description: Based on panel data of 28 manufacturing industries sectors in 2005–2015 years, this paper first estimated the level of 28 manufacturing industries sectors technological progress, and then, using panel threshold technology, calculated the impact of three environmental regulation change rates on technological progress change rate to analyze the relationship between environmental regulations and technology innovation. The results show that: (1) The influence of the change rates of waste gas, wastewater and solid waste’s environmental regulation intensity towards the change rate of production technological progress has two thresholds. Only the proper change rate of environmental regulation intensity can lead to a desired change rate of production technological progress. However, there are differences in the thresholds of the change rates of three kinds of environmental regulation intensities, and the optimal change rates of waste gas, wastewater and waste solid are 15.07%–55.31%, 17.06%–38.02% and 33.12%–47.99%, respectively. (2) In the change rates of waste gas, wastewater and waste solid’s environmental regulation intensity, there are 8, 10 and 3 industries at a reasonable level, respectively, while others industries are below or above the reasonable level and unable to stimulate technical and management innovation in enterprises. Hence, to achieve a win-win situation between environmental protection and production technological progress, different environmental regulation intensities should be planned according to different pollutants in various manufacturing industries.
    Electronic ISSN: 2071-1050
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by MDPI Publishing
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  • 3
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    Three New C19-Diterpenoid Alkaloids from Aconitum transsectum (2012)
    Wiley-Blackwell
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    Publication Date: 2012-03-17
    Description: Three new C 19 -diterpenoid alkaloids, named aconitramines A ( 1 ), B ( 2 ), and C ( 3 ), were isolated from Aconitum transsectum. By UV, IR, 1D- and 2D-NMR, and MS analyses, their structures were elucidated as 18-methoxyvilmoraconitine, 18-demethoxydolichotine A, and 18-demethoxydolichotine B. Compound 1 is the second known C 19 -diterpenoid alkaloid with a three-membered ring formed by C(8), C(9), and C(10).
    Print ISSN: 0018-019X
    Electronic ISSN: 1522-2675
    Topics: Chemistry and Pharmacology
    Published by Wiley-Blackwell
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  • 4
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    IJERPH, Vol. 11, Pages 4441-4448: Adaptive Response in Animals Exposed to Non-Ionizing Radiofrequency Fields: Some Underlying Mechanisms (2014)
    MDPI Publishing
    Details
    Publication Date: 2014-04-23
    Description: During the last few years, our research group has been investigating the phenomenon of adaptive response in animals exposed to non-ionizing radiofrequency fields. The results from several separate studies indicated a significant increase in survival, decreases in genetic damage as well as oxidative damage and, alterations in several cellular processes in mice pre-exposed to radiofrequency fields and subsequently subjected to sub-lethal or lethal doses of γ-radiation or injected with bleomycin, a radiomimetic chemical mutagen. These observations indicated the induction of adaptive response providing the animals the ability to resist subsequent damage. Similar studies conducted by independent researchers in mice and rats have supported our observation on increased survival. In this paper, we have presented a brief review of all of our own and other independent investigations on radiofrequency fields-induced adaptive response and some underlying mechanisms discussed.
    Print ISSN: 1661-7827
    Electronic ISSN: 1660-4601
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Published by MDPI Publishing
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  • 5
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    IJERPH, Vol. 11, Pages 6085-6098: Effort-Reward Imbalance at School and Depressive Symptoms in Chinese Adolescents: The Role of Family Socioeconomic Status (2014)
    MDPI Publishing
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    Publication Date: 2014-06-11
    Description: Depression is a major mental health problem during adolescence. This study, using a sample of Chinese adolescents, examined the separate and combined effects of perceived school-related stress and of family socioeconomic status (SES) on the prevalence of depressive symptoms. A total of 1774 Chinese students from Grades 7–12 were recruited into our questionnaire survey. School-related stress was measured by the Effort-Reward Imbalance Questionnaire-School Version, family SES was assessed by a standardized question, and depressive symptoms were evaluated by the Center for Epidemiological Studies Depression Scale for Children. Multivariate logistic regression was applied, adjusting for age, gender, grade, smoking, alcohol drinking and physical activity. It was found that high school-related stress and low family SES were associated with elevated odds of depressive symptoms, respectively. The effect of school-related stress was particularly strong in low SES group. In adolescents with both high stress at school and low SES, the odds ratio was 9.18 (95% confidence interval = 6.53–12.89) compared to the reference group (low stress at school and high SES). A significant synergistic interaction effect was observed (synergy index = 2.28, 95% confidence interval = 1.56–3.32). The findings indicated that perceived school-related stress, in terms of effort-reward imbalance, was related to depressive symptoms in this sample of Chinese adolescents. The strong interaction with family SES suggests that health promoting efforts in school settings should be targeted specifically at these socially deprived groups.
    Print ISSN: 1661-7827
    Electronic ISSN: 1660-4601
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Published by MDPI Publishing
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  • 6
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    Seismic stratigraphy of the central South China Sea basin and implications for neotectonics (2015)
    Wiley-Blackwell
    Details
    Publication Date: 2015-02-08
    Description: Coring/logging data and physical property measurements from International Ocean Discovery Program Expedition 349 are integrated with, and correlated to, reflection seismic data to map seismic sequence boundaries and facies of the central basin and neighboring regions of the South China Sea. First-order sequence boundaries are interpreted, which are Oligocene/Miocene, middle Miocene/late Miocene, Miocene/Pliocene, and Pliocene/Pleistocene boundaries. A characteristic early Pleistocene strong reflector is also identified, which marks the top of extensive carbonate-rich deposition in the southern East and Southwest Subbasins. The fossil spreading ridge and the boundary between the East and Southwest Subbasins acted as major sedimentary barriers, across which seismic facies changes sharply and cannot be easily correlated. The sharp seismic facies change along the Miocene-Pliocene boundary indicates that a dramatic regional tectonostratigraphic event occurred at about 5 Ma, coeval with the onsets of uplift of Taiwan and accelerated subsidence and transgression in the northern margin. The depocenter or the area of the highest sedimentation rate switched from the northern East Subbasin during the Miocene to the Southwest Subbasin and the area close to the fossil ridge in the southern East Subbasin in the Pleistocene. The most active faulting and vertical uplifting now occur in the southern East Subbasin, caused most likely by the active and fastest subduction/obduction in the southern segment of the Manila Trench and the collision between the Northeast Palawan and the Luzon arc. Timing of magmatic intrusions and seamounts constrained by seismic stratigraphy in the central basin varies and does not show temporal pulsing in their activities.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley-Blackwell on behalf of American Geophysical Union (AGU).
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  • 7
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    IJERPH, Vol. 12, Pages 2071-2087: Circadian Rhythmicity of Antioxidant Markers in Rats Exposed to 1.8 GHz Radiofrequency Fields (2015)
    MDPI Publishing
    Details
    Publication Date: 2015-02-13
    Description: Background: The potential health risks of exposure to Radiofrequency Fields (RF) emitted by mobile phones are currently of considerable public interest, such as the adverse effects on the circadian rhythmicities of biological systems. To determine whether circadian rhythms of the plasma antioxidants (Mel, GSH-Px and SOD) are affected by RF, we performed a study on male Sprague Dawley rats exposed to the 1.8 GHz RF. Methods: All animals were divided into seven groups. The animals in six groups were exposed to 1.8 GHz RF (201.7 μW/cm2 power density, 0.05653 W/kg specific absorption rate) at a specific period of the day (3, 7, 11, 15, 19 and 23 h GMT, respectively), for 2 h/day for 32 consecutive days. The rats in the seventh group were used as sham-exposed controls. At the end of last RF exposure, blood samples were collected from each rat every 4 h (total period of 24 h) and also at similar times from sham-exposed animals. The concentrations of three antioxidants (Mel, GSH-Px and SOD) were determined. The data in RF-exposed rats were compared with those in sham-exposed animals. Results: circadian rhythms in the synthesis of Mel and antioxidant enzymes, GSH-Px and SOD, were shifted in RF-exposed rats compared to sham-exposed animals: the Mel, GSH-Px and SOD levels were significantly decreased when RF exposure was given at 23 and 3 h GMT. Conclusion: The overall results indicate that there may be adverse effects of RF exposure on antioxidant function, in terms of both the daily antioxidative levels, as well as the circadian rhythmicity.
    Print ISSN: 1661-7827
    Electronic ISSN: 1660-4601
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Published by MDPI Publishing
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  • 8
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    Remote Sensing, Vol. 9, Pages 137: Urban Expansion and Its Impact on the Land Use Pattern in Xishuangbanna since the Reform and Opening up of China (2017)
    MDPI Publishing
    Details
    Publication Date: 2017-02-09
    Description: Since the Chinese government carried out the reform and opening up policy, Xishuangbanna Dai Autonomous Prefecture has experienced rapid urbanization and dramatic land use change. This research aims at analyzing urban expansion in Xishuangbanna and its impact on the land use pattern using combined methods, including radar graph, the gradient-direction method and landscape metrics. Seven land use maps from 1976 to 2015 were generated and analyzed, respectively. The results showed that urban and rubber expanded rapidly, while forest decreased during the last 40 years. The city proper, the county town of Menghai and the county town of Mengla showed the most significant and fastest urban expansion rates. In response to rapid urban expansion, land use types outside urban areas changed dramatically. In Jinghong and Mengla, urban areas were usually surrounded by paddy, shrub, rubber and forest in 1976, while most areas were dominated by rubber by 2015. With the development of Xishuangbanna, landscape diversity increased along urban-rural gradients, but decreased in some key urban areas. Urban expansion slightly reduced the connectivity of forest and increased agglomeration of rubber at the same time. Based on the analyses above, we moved forward to discuss the consequences of urban expansion, rubber plantations and land fragmentation.
    Electronic ISSN: 2072-4292
    Topics: Architecture, Civil Engineering, Surveying , Geography
    Published by MDPI Publishing
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  • 9
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    Quantification of familial risk of nasopharyngeal carcinoma in a high-incidence area (2017)
    Wiley-Blackwell
    In: Cancer
    Details
    Publication Date: 2017-02-28
    Description: BACKGROUND To the authors' knowledge, no studies to date have explored familial risks of nasopharyngeal carcinoma (NPC) in detail and quantified its lifetime risk in high-incidence populations. METHODS The authors conducted a population-based case-control study of 2499 NPC cases and 2576 controls randomly selected in southern China from 2010 through 2014. Unconditional logistic regression was used to estimate multivariable-adjusted odds ratios (ORs) with 95% confidence intervals (95% CIs) associated with a family history of NPC. In addition, the authors compiled a reconstructed cohort comprising 40,781 first-degree relatives of cases and controls to calculate the lifetime cumulative risk of NPC. RESULTS Individuals with a first-degree family history of NPC were found to be at a 〉4-fold risk of NPC (OR, 4.6; 95% CI, 3.5-6.1) compared with those without such a history, but had no excess risk of other malignancies. The excess risk was higher for a maternal than a paternal history and was slightly stronger for a sibling compared with a parental history, and for a sororal than a fraternal history. Among relatives of cases, the cumulative risk of NPC up to age 74 years was 3.7% (95% CI, 3.3%-4.2%), whereas that among relatives of controls was 0.9% (95% CI, 0.7%-1.2%). Cumulative risk was higher in siblings than in parents among relatives of cases, whereas no such difference was noted among relatives of controls. CONCLUSIONS Individuals with a family history of NPC have a substantially higher risk of NPC. These relative and cumulative risk estimates can guide the development of strategies for early detection and clinical consultation in populations with a high incidence of NPC. Cancer 2017 . © 2017 American Cancer Society .
    Print ISSN: 0008-543X
    Electronic ISSN: 1097-0142
    Topics: Biology , Medicine
    Published by Wiley-Blackwell on behalf of The American Cancer Society.
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