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  • 1
    Online Resource
    Online Resource
    A Lipophilic Fucoxanthin-Rich Phaeodactylum tricornutum Extract Ameliorates Effects of Diet-Induced Obesity in C57BL/6J Mice
    MDPI AG ; 2019
    In:  Nutrients Vol. 11, No. 4 ( 2019-04-06), p. 796-
    Details
    In: Nutrients, MDPI AG, Vol. 11, No. 4 ( 2019-04-06), p. 796-
    Abstract: Phaeodactylum tricornutum (P. tricornutum) comprise several lipophilic constituents with proposed anti-obesity and anti-diabetic properties. We investigated the effect of an ethanolic P. tricornutum extract (PTE) on energy metabolism in obesity-prone mice fed a high fat diet (HFD). Six- to eight-week-old male C57BL/6J mice were switched to HFD and, at the same time, received orally placebo or PTE (100 mg or 300 mg/kg body weight/day). Body weight, body composition, and food intake were monitored. After 26 days, blood and tissue samples were collected for biochemical, morphological, and gene expression analyses. PTE-supplemented mice accumulated fucoxanthin metabolites in adipose tissues and attained lower body weight gain, body fat content, weight of white adipose tissue (WAT) depots, and inguinal WAT adipocyte size than controls, independent of decreased food intake. PTE supplementation was associated with lower expression of Mest (a marker of fat tissue expandability) in WAT depots, lower gene expression related to lipid uptake and turnover in visceral WAT, increased expression of genes key to fatty acid oxidation and thermogenesis (Cpt1, Ucp1) in subcutaneous WAT, and signs of thermogenic activation including enhanced UCP1 protein in interscapular brown adipose tissue. In conclusion, these data show the potential of PTE to ameliorate HFD-induced obesity in vivo.
    Type of Medium: Online Resource
    ISSN: 2072-6643
    URL: Article
    DOI: 10.3390/nu11040796
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2518386-2
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  • 2
    Online Resource
    Online Resource
    A Linear Programming Approach for Modeling and Simulation of Growth and Lipid Accumulation of Phaeodactylum tricornutum
    MDPI AG ; 2013
    In:  Energies Vol. 6, No. 10 ( 2013-10-18), p. 5333-5356
    Details
    In: Energies, MDPI AG, Vol. 6, No. 10 ( 2013-10-18), p. 5333-5356
    Type of Medium: Online Resource
    ISSN: 1996-1073
    URL: Article
    DOI: 10.3390/en6105333
    Language: English
    Publisher: MDPI AG
    Publication Date: 2013
    detail.hit.zdb_id: 2437446-5
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  • 3
    Online Resource
    Online Resource
    Comprehensive Computational Model for Coupled Fluid Flow, Mass Transfer, and Light Supply in Tubular Photobioreactors Equipped with Glass Sponges
    MDPI AG ; 2022
    In:  Energies Vol. 15, No. 20 ( 2022-10-18), p. 7671-
    Details
    In: Energies, MDPI AG, Vol. 15, No. 20 ( 2022-10-18), p. 7671-
    Abstract: The design and optimization of photobioreactor(s) (PBR) benefit from the development of robust and quantitatively accurate computational fluid dynamics (CFD) models, which incorporate the complex interplay of fundamental phenomena. In the present work, we propose a comprehensive computational model for tubular photobioreactors equipped with glass sponges. The simulation model requires a minimum of at least three submodels for hydrodynamics, light supply, and biomass kinetics, respectively. First, by modeling the hydrodynamics, the light–dark cycles can be detected and the mixing characteristics of the flow (besides the mass transport) can be analyzed. Second, the radiative transport model is deployed to predict the local light intensities according to the wavelength of the light and scattering characteristics of the culture. The third submodel implements the biomass growth kinetic by coupling the local light intensities to hydrodynamic information of the CO2 concentration, which allows to predict the algal growth. In combination, the novel mesoscopic simulation model is applied to a tubular PBR with transparent walls and an internal sponge structure. We showcase the coupled simulation results and validate specific submodel outcomes by comparing the experiments. The overall flow velocity, light distribution, and light intensities for individual algae trajectories are extracted and discussed. Conclusively, such insights into complex hydrodynamics and homogeneous illumination are very promising for CFD-based optimization of PBR.
    Type of Medium: Online Resource
    ISSN: 1996-1073
    URL: Article
    DOI: 10.3390/en15207671
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2437446-5
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  • 4
    Online Resource
    Online Resource
    Effect of Traditional Household Processes on Iron, Zinc and Copper Bioaccessibility in Black Bean (Phaseolus vulgaris L.)
    MDPI AG ; 2018
    In:  Foods Vol. 7, No. 8 ( 2018-07-31), p. 123-
    Details
    In: Foods, MDPI AG, Vol. 7, No. 8 ( 2018-07-31), p. 123-
    Abstract: Micronutrient deficiencies are a major public health problem. Beans are an important plant-based source of iron, zinc and copper, but their absorption is reduced in the presence of anti-nutrients such as phytates, polyphenols and tannins. Soaking and discarding the soaking water before cooking is unanimously recommended, but this can result in mineral loss. Data on the consequences for mineral bioaccessibility is still limited. This study aimed to evaluate iron, zinc and copper bioaccessibility in black beans cooked (regular pan, pressure cooker) with and without the soaking water. For that, three batches of black beans were investigated in triplicate, each split in nine parts (raw grains and four different household processes in duplicate) and analyzed by applying the quarter technique, resulting in a grand total of 164 samples. Minerals were quantified by ICP-MS (inductively coupled plasma mass spectrometry), myo-inositol phosphates (InsP5, InsP6) by HPLC (high-performance liquid chromatography) ion-pair chromatography, total polyphenols using Folin-Denis reagent and condensed tannins using Vanillin assay. Mineral bioaccessibility was determined by in vitro digestion and dialysis. All treatments resulted in a statistically significant reduction of total polyphenols (30%) and condensed tannins (20%). Only when discarding the soaking water a loss of iron (6%) and copper (30%) was observed, and InsP6 was slightly decreased (7%) in one treatment. The bioaccessibility of iron and zinc were low (about 0.2% iron and 35% zinc), but copper presented high bioaccessibility (about 70%). Cooking beans under pressure without discarding the soaking water resulted in the highest bioaccessibility levels among all household procedures. Discarding the soaking water before cooking did not improve the nutritional quality of the beans.
    Type of Medium: Online Resource
    ISSN: 2304-8158
    URL: Article
    DOI: 10.3390/foods7080123
    Language: English
    Publisher: MDPI AG
    Publication Date: 2018
    detail.hit.zdb_id: 2704223-6
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