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  • MDPI AG  (181)
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  • 1
    Online Resource
    Online Resource
    Bioactive Compounds from Plant-Based Functional Foods: A Promising Choice for the Prevention and Management of Hyperuricemia
    MDPI AG ; 2020
    In:  Foods Vol. 9, No. 8 ( 2020-07-23), p. 973-
    Details
    In: Foods, MDPI AG, Vol. 9, No. 8 ( 2020-07-23), p. 973-
    Abstract: Hyperuricemia is a common metabolic disease that is caused by high serum uric acid levels. It is considered to be closely associated with the development of many chronic diseases, such as obesity, hypertension, hyperlipemia, diabetes, and cardiovascular disorders. While pharmaceutical drugs have been shown to exhibit serious side effects, and bioactive compounds from plant-based functional foods have been demonstrated to be active in the treatment of hyperuricemia with only minimal side effects. Indeed, previous reports have revealed the significant impact of bioactive compounds from plant-based functional foods on hyperuricemia. This review focuses on plant-based functional foods that exhibit a hypouricemic function and discusses the different bioactive compounds and their pharmacological effects. More specifically, the bioactive compounds of plant-based functional foods are divided into six categories, namely flavonoids, phenolic acids, alkaloids, saponins, polysaccharides, and others. In addition, the mechanism by which these bioactive compounds exhibit a hypouricemic effect is summarized into three classes, namely the inhibition of uric acid production, improved renal uric acid elimination, and improved intestinal uric acid secretion. Overall, this current and comprehensive review examines the use of bioactive compounds from plant-based functional foods as natural remedies for the management of hyperuricemia.
    Type of Medium: Online Resource
    ISSN: 2304-8158
    URL: Article
    DOI: 10.3390/foods9080973
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2704223-6
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  • 2
    Online Resource
    Online Resource
    WNT16B from Ovarian Fibroblasts Induces Differentiation of Regulatory T Cells through β-Catenin Signal in Dendritic Cells
    MDPI AG ; 2014
    In:  International Journal of Molecular Sciences Vol. 15, No. 7 ( 2014-07-21), p. 12928-12939
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 15, No. 7 ( 2014-07-21), p. 12928-12939
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms150712928
    Language: English
    Publisher: MDPI AG
    Publication Date: 2014
    detail.hit.zdb_id: 2019364-6
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    Augmented Anticancer Effects of Cantharidin with Liposomal Encapsulation: In Vitro and In Vivo Evaluation
    MDPI AG ; 2017
    In:  Molecules Vol. 22, No. 7 ( 2017-06-24), p. 1052-
    Details
    In: Molecules, MDPI AG, Vol. 22, No. 7 ( 2017-06-24), p. 1052-
    Type of Medium: Online Resource
    ISSN: 1420-3049
    URL: Article
    DOI: 10.3390/molecules22071052
    Language: English
    Publisher: MDPI AG
    Publication Date: 2017
    detail.hit.zdb_id: 2008644-1
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  • 4
    Online Resource
    Online Resource
    Evolution Characteristics of Electric Field-Related Properties in Polymorphic Piezoceramics with Temperature-Impelled Phase Transition
    MDPI AG ; 2023
    In:  Crystals Vol. 13, No. 9 ( 2023-08-30), p. 1324-
    Details
    In: Crystals, MDPI AG, Vol. 13, No. 9 ( 2023-08-30), p. 1324-
    Abstract: In this work, to systematically investigate the evolution characteristics of electrical properties in polymorphic piezoceramics, the Ba(Ti0.92Zr0.08)O3 ceramics are selected as a paradigm that possesses all the general phase structures above room temperature. It is found that the evolution of electrical properties with temperature change can be divided into three stages based on phase structure transforming: high ferroelectric and stable strain properties at R and R-O, high ferroelectric and enhanced strain/converse piezoelectric properties at O, O-T, and T phase, and the rapidly decreased ferroelectric and strain properties in T-C and C phase. However, the ferroelectric and strain properties all increase with rising electric field and their evolution can be divided into two parts based on phase structures. The high property and slow increase rate are present at R, R-O, O, and O-T, while the poor property but a high increase rate is present around T-C. Similar results can be found in the evolution of electrostrictive property. Finally, the highest d33* of ~1240 pm/V and Q33 of ~0.053 m4/C2 are obtained at O-T due to the high ferroelectricity but easy domain switching. This work affords important guidance for the property optimization of polymorphic piezoceramics.
    Type of Medium: Online Resource
    ISSN: 2073-4352
    URL: Article
    DOI: 10.3390/cryst13091324
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2661516-2
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  • 5
    Online Resource
    Online Resource
    Design, Synthesis, Biological Evaluation and In Silico Studies of Pyrazole-Based NH2-Acyl Oseltamivir Analogues as Potent Neuraminidase Inhibitors
    MDPI AG ; 2021
    In:  Pharmaceuticals Vol. 14, No. 4 ( 2021-04-16), p. 371-
    Details
    In: Pharmaceuticals, MDPI AG, Vol. 14, No. 4 ( 2021-04-16), p. 371-
    Abstract: Oseltamivir represents one of the most successful neuraminidase (NA) inhibitors in the current anti-influenza therapy. The 150-cavity of NA was identified as an additional binding pocket, and novel NA inhibitors have been designed to occupy the 150-cavity based on the structure information of oseltamivir carboxylate (OC) in complex with NA. In this study, a series of C-5-NH2-acyl derivatives of OC containing the pyrazole moiety were synthesized. Several derivatives exhibited substantial inhibitory activity against NA. Moreover, in silico ADME evaluation indicated that the derivatives were drug-like with higher oral absorption rates and greater cell permeability than OC. Additionally, molecular docking studies revealed that the derivatives interacted with both the NA enzyme active site and 150-cavity as expected. The results provided useful information for further structural optimization of OC.
    Type of Medium: Online Resource
    ISSN: 1424-8247
    URL: Article
    DOI: 10.3390/ph14040371
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2193542-7
    SSG: 15,3
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  • 6
    Online Resource
    Online Resource
    Effects of Sb Doping on Electrical Conductivity Properties in Fine-Grain KNN-Based Ferroelectric Ceramics
    MDPI AG ; 2022
    In:  Crystals Vol. 12, No. 9 ( 2022-09-17), p. 1311-
    Details
    In: Crystals, MDPI AG, Vol. 12, No. 9 ( 2022-09-17), p. 1311-
    Abstract: In this work, the effects of Sb doping on the electrical conductivity of fine-grain 0.9(K0.5Na0.5)(Nb1−xSbx)O3-0.1Bi(Ni2/3Nb1/3)O3 (KNNSx-BNN) ceramics were systemically investigated. It was found that the grain size decreases from ~900 nm (x = 0) to ~340–400 nm (x = 0.06–0.08), and then increases again to ~700 nm (x = 0.10). This is because the solubility limit of Sb doping is about 0.08 in this ceramic, and more Sb doping will facilitate the grain growth as the sintering aids. Impedance and conductivity analyses reveal that the grain resistance and its activation energy show a similar changing tendency with grain size, while grain boundary conductivity steadily increases after Sb doping. In this process, the grain contribution on ceramic conductivity changes with grain size variation, and grain boundary contribution becomes more obvious with increasing doping content. The reduction in grain size, improvement in grain boundary density and doping ions entering into the grain boundary should contribute to the evolution of electrical conductivity properties after Sb doping in KNN-based ferroelectric ceramics.
    Type of Medium: Online Resource
    ISSN: 2073-4352
    URL: Article
    DOI: 10.3390/cryst12091311
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2661516-2
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  • 7
    Online Resource
    Online Resource
    SMRT and Illumina RNA-Seq Identifies Potential Candidate Genes Related to the Double Flower Phenotype and Unveils SsAP2 as a Key Regulator of the Double-Flower Trait in Sagittaria sagittifolia
    MDPI AG ; 2022
    In:  International Journal of Molecular Sciences Vol. 23, No. 4 ( 2022-02-17), p. 2240-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 23, No. 4 ( 2022-02-17), p. 2240-
    Abstract: Double flowers are one of the important objectives of ornamental plant breeding. Sagittaria sagittifolia is an aquatic herb in the Alismataceae family that is widely used as an ornamental plant in gardens. However, the reference genome has not been published, and the molecular regulatory mechanism of flower formation remains unclear. In this study, single molecule real-time (SMRT) sequencing technology combined with Illumina RNA-Seq was used to perform a more comprehensive analysis of S. sagittifolia for the first time. We obtained high-quality full-length transcripts, including 53,422 complete open reading frames, and identified 5980 transcription factors that belonged to 67 families, with many MADS-box genes involved in flower formation being obtained. The transcription factors regulated by plant hormone signals played an important role in the development of double flowers. We also identified an AP2 orthologous gene, SsAP2, with a deletion of the binding site for miR172, that overexpressed SsAP2 in S. sagittifolia and exhibited a delayed flowering time and an increased number of petals. This study is the first report of a full-length transcriptome of S. sagittifolia. These reference transcripts will be valuable resources for the analysis of gene structures and sequences, which provide a theoretical basis for the molecular regulatory mechanism governing the formation of double flowers.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms23042240
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2019364-6
    SSG: 12
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  • 8
    Online Resource
    Online Resource
    AC Breakdown Characteristics of c-C4F8/N2 Gas Mixtures in an Extremely Non-Uniform Electric Field
    MDPI AG ; 2018
    In:  Energies Vol. 11, No. 12 ( 2018-12-19), p. 3533-
    Details
    In: Energies, MDPI AG, Vol. 11, No. 12 ( 2018-12-19), p. 3533-
    Abstract: Octafluorocyclobutane (c-C4F8) is one of the environmentally friendly gases with the potential to replace SF6. In this paper, the AC breakdown characteristics of c-C4F8/N2 mixture in an extremely non-uniform electric field were studied; the effects of the gas pressure, electrode distance, and c-C4F8 volume fraction on the breakdown voltage were analyzed; and the feasibility of replacing SF6 with c-C4F8/N2 was verified. The results show that the breakdown voltage of c-C4F8 /N2 increases with an increase in pressure, electrode spacing, and volume fraction of c-C4F8 in an extremely non-uniform electric field. Under the same conditions, the breakdown voltage of 20%c-C4F8/80%N2 is 46–90% that of 20%SF6/80%N2. When the pressure is 0.3 MPa, the 20%c-C4F8/80%N2 breakdown voltage can reach over 57% that of SF6. Taking into consideration the environment, liquefaction temperature, and insulation strength, 20%c-C4F8/80%N2 may replace SF6 used for medium- and low-voltage equipment.
    Type of Medium: Online Resource
    ISSN: 1996-1073
    URL: Article
    DOI: 10.3390/en11123533
    Language: English
    Publisher: MDPI AG
    Publication Date: 2018
    detail.hit.zdb_id: 2437446-5
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  • 9
    Online Resource
    Online Resource
    Recent Advances and Perspectives Regarding Paper-Based Sensors for Salivary Biomarker Detection
    MDPI AG ; 2023
    In:  Chemosensors Vol. 11, No. 7 ( 2023-07-07), p. 383-
    Details
    In: Chemosensors, MDPI AG, Vol. 11, No. 7 ( 2023-07-07), p. 383-
    Abstract: Paper-based sensors overcome the drawbacks of conventional sensors in terms of their flexibility, portability, and stability compared to conventional sensors. Moreover, as a noninvasive bodily fluid, saliva contains various biomarkers related to physical status, which makes it perfectly matched with to use of paper-based sensors to manufacture a convenient and inexpensive disposable sensing device. This review focuses on the recent advances and progress in the design of paper-based salivary sensors and their applications. The first part mainly discusses various paper-based sensors and their advanced compositions, including dipstick assay, lateral flow assay, and microfluidic analytical device. Different detection methods in salivary biomarker detection are specially introduced in the secondary section, then their multiple potential applications and prospects are summarized. The sensor has excellent advantages for saliva detection, provides a reliable platform for point-of-care tests and telemedicine, and epically promotes the development of the medical Internet of Things.
    Type of Medium: Online Resource
    ISSN: 2227-9040
    URL: Article
    DOI: 10.3390/chemosensors11070383
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2704218-2
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  • 10
    Online Resource
    Online Resource
    Nusbiarylins Inhibit Transcription and Target Virulence Factors in Bacterial Pathogen Staphylococcus aureus
    MDPI AG ; 2020
    In:  International Journal of Molecular Sciences Vol. 21, No. 16 ( 2020-08-11), p. 5772-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 21, No. 16 ( 2020-08-11), p. 5772-
    Abstract: The emergence of multidrug resistance in the clinically significant pathogen Staphylococcus aureus is a global health burden, compounded by a diminishing drug development pipeline, and a lack of approved novel antimicrobials. Our previously reported first-in-class bacterial transcription inhibitors “nusbiarylins” presented a promising prospect towards the discovery of novel antimicrobial agents with a novel mechanism. Here we investigated and characterised the lead nusbiarylin compound, MC4, and several of its chemical derivatives in both methicillin-resistant S. aureus (MRSA) and the S. aureus type strains, demonstrating their capacity for the arrest of growth and cellular respiration, impairment of RNA and intracellular protein levels at subinhibitory concentrations. In some instances, derivatives of MC4 were also shown to attenuate the production of staphylococcal virulence factors in vitro, such as the exoproteins α-toxin and Panton–Valentine Leukocidin (PVL). Trends observed from quantitative PCR assays suggested that nusbiarylins elicited these effects possibly by acting via but not limited to the modulation of global regulatory pathways, such as the agr regulon, which coordinates the expression of S. aureus genes associated with virulence. Our findings encourage the continued development of more potent compounds within this novel family of bacterial transcription inhibitors.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms21165772
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2019364-6
    SSG: 12
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