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  • Hindawi Limited  (2)
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  • Hindawi Limited  (2)
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  • 1
    In: Geofluids, Hindawi Limited, Vol. 2022 ( 2022-3-17), p. 1-21
    Abstract: Hydrochemistry and isotopes are studied for characterizations of geothermal waters, groundwaters, and surface waters in Leizhou Peninsula (LZ) and the northern part of Hainan Island (HN) across the tensile-tectonic Qiongzhou Strait, southern China. Water chemistry results showed that most geothermal waters are of alkaline and HCO3-Na types, while shallow groundwater samples were significantly different with HCO3-Ca, HCO3-Mg, and HNO3-Ca types. Stable isotope data indicated that the source of LZ geothermal waters is of atmospheric precipitation, while HN geothermal water has a slight “oxygen drift”. Cation geothermometers and silica geothermometers could appropriately predict reservoir temperatures. Based on multicomponent mineral equilibria and quart geothermometer without steam loss, reservoir temperatures were estimated to be in the range of 65.0°C to 165.0°C at an average circulation depth of 2023 m, substantiated with data from a thousand-meter-depth borehole. The saturation indexes (SI) simulated by PHREEQC and Na-K-Mg triangle diagram revealed that the chemical components in the geothermal waters are possibly derived from water-rock interactions at high temperatures. Four simulation paths were established to calculate the mass flux of minerals by PHREEQC program. The hydrothermal circulation process of the volcanic rocks on both sides of the Qiongzhou Strait was similar, but the water-mineral reactions of Leizhou Peninsula were more intense. During the high-temperature hydrothermal deep circulation in the central part of Hainan Island, the molar transfer was low and the degree of mineral reaction is weak. Finally, the geothermal genetic mechanism for the study area of the extensional geostructure was proposed. The findings mark the characteristics for the tensile-tectonic region in slight “oxygen shift”, low values of 87Sr/86Sr for possible deep source from the mantle, and higher reservoir temperatures at shallower circulation depths.
    Type of Medium: Online Resource
    ISSN: 1468-8123 , 1468-8115
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2045012-6
    SSG: 13
    Location Call Number Limitation Availability
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  • 2
    Online Resource
    Online Resource
    Hindawi Limited ; 2020
    In:  International Journal of Endocrinology Vol. 2020 ( 2020-01-31), p. 1-11
    In: International Journal of Endocrinology, Hindawi Limited, Vol. 2020 ( 2020-01-31), p. 1-11
    Abstract: Obesity, caused by an increased number and volume of adipocytes, is a global epidemic that seriously threatens human health. Bone marrow mesenchymal stem cells (BMSCs) can differentiate into adipocytes. All-trans retinoic acid (atRA, the active form of vitamin A) inhibits the adipogenic differentiation of BMSCs through its receptor RARG. The expression level of FRA1 (FOS like 1, AP-1 transcription factor subunit) in atRA-treated BMSCs increased, suggesting that atRA-mediated inhibition of BMSCs adipogenesis involves FRA1. BMSCs were transfected with adenovirus overexpressing Fra1 (ad-fra1) or silenced for Fra1 (si-fra1) and then treated with atRA. BMSCs treated with atRA and treated with ad-fra1 showed decreased mRNA and protein levels of key adipogenic genes ( Pparg2 , Cebpa ) and adipogenesis-associated genes ( Cd36 , Fabp , Lpl , and Plin ); atRA had a stronger inhibitory effect on adipogenesis compared with that in the ad-fra1 group. Adipogenic gene expression in Fra1 -silenced BMSCs was significantly upregulated. Compared with that in the atRA group, the si-fra1 + atRA also upregulated adipogenic gene expression. However, compared with si-fra1, si-fra1 + atRA significantly inhibited adipogenic differentiation. Chromatin immunoprecipitation showed that RARG directly regulates Fra1 and FRA1 directly regulates Pparg2 and Cebpa . The results supported the conclusion that atRA inhibits BMSC adipogenesis partially through the RARG-FRA1-PPARG2 or the CEBPA axis or both. Thus, vitamin A might be used to treat obesity and its related diseases.
    Type of Medium: Online Resource
    ISSN: 1687-8337 , 1687-8345
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2502951-4
    Location Call Number Limitation Availability
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