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  • Hindawi Limited  (38)
  • 1
    Online Resource
    Online Resource
    Effect of Massage on the TLR4 Signalling Pathway in Rats with Neuropathic Pain
    Hindawi Limited ; 2020
    In:  Pain Research and Management Vol. 2020 ( 2020-12-16), p. 1-6
    Details
    In: Pain Research and Management, Hindawi Limited, Vol. 2020 ( 2020-12-16), p. 1-6
    Abstract: This study set out to investigate the effect of massage on the Toll-like receptor 4 (TLR4) signalling pathway in the dorsal root ganglia of rats that had undergone spinal nerve ligation (SNL), with the hypothesis that massage could be used as an analgesic. Forty female SD rats were randomly divided into 5 groups: the control group, sham-operated group, model group, sham massage group, and massage group. There were 8 rats in each group. SNL rat models were established in the model group, sham massage group, and massage group. Rats in the sham-operated group underwent surgery to expose the vertebral nerves, but no further procedures were performed. The control group consisted of intact animals. The rats in the massage group underwent massage using a massage simulation machine once a day for 14 d in succession; the hind limbs of the rats in the sham massage group were gently touched with a cloth bag once a day for 14 continuous days. The rats in the control group, the sham-operated group, and the model group did not receive any intervention and were observed for 14 d. Paw withdrawal thermal latency (PWTL) and paw withdrawal mechanical threshold (PWMT) of rats in each group were detected 1 d before modelling and at 1, 3, 7, and 14 d after modelling. Fourteen days after modelling, the expression levels of TLR4, IRAK1, TRAF6, TNF-α, and IL-6 were detected in all rats. The PWTL and PWMT of SNL rats were decreased, while these parameters were elevated after massage. SNL rats showed higher levels of TLR4, IRAK1, TRAF6, IL-6, and TNF-α, and massage effectively lowered the expression levels of these molecules. Inhibiting activation of the TLR4 signalling pathway, which can reduce the release of inflammatory factors, may be one mechanism by which massage treats neuropathic pain.
    Type of Medium: Online Resource
    ISSN: 1918-1523 , 1203-6765
    URL: Article
    DOI: 10.1155/2020/8309745
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2048409-4
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  • 2
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    Multifunctionalized Microscale Ultrasound Contrast Agents for Precise Theranostics of Malignant Tumors
    Hindawi Limited ; 2019
    In:  Contrast Media & Molecular Imaging Vol. 2019 ( 2019-07-07), p. 1-18
    Details
    In: Contrast Media & Molecular Imaging, Hindawi Limited, Vol. 2019 ( 2019-07-07), p. 1-18
    Abstract: In ultrasonography, ultrasound contrast agents (UCAs) that possess high acoustic impedance mismatch with the bulk medium are frequently employed to highlight the borders between tissues by enhanced ultrasound scattering in a clinic. Typically, the most common UCA, microbubble, is generally close in size to a red blood cell ( 〈 ∼10 μm). These microscale UCAs cannot be directly entrapped into the target cells but generate several orders of magnitude stronger echo signals than the nanoscale ones. And their large containment and high ultrasound responsiveness also greatly facilitate to perform combined treatments, e.g., drug delivery and other imaging techniques. So multifunctionalized microscale UCAs appear on this scene and keep growing toward a promising direction for precise theranostics. In this review, we systematically summarize the new advances in the principles and preparations of multifunctionalized microscale UCAs and their medical applications for malignant tumors.
    Type of Medium: Online Resource
    ISSN: 1555-4309 , 1555-4317
    URL: Article
    DOI: 10.1155/2019/3145647
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2222967-X
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  • 3
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    MAIP1-Related Tumor Immune Infiltration: As a Potential Prognostic Biomarker for Esophageal Cancer
    Hindawi Limited ; 2022
    In:  Journal of Immunology Research Vol. 2022 ( 2022-6-14), p. 1-11
    Details
    In: Journal of Immunology Research, Hindawi Limited, Vol. 2022 ( 2022-6-14), p. 1-11
    Abstract: Background. Esophageal cancer (EC), a common malignant tumor of digestive tract, is also one of the most deadly cancers. Accumulating studies have shown that the initiating and progressing multiple human diseases were closely related to the expression of MAIP. However, the specific roles and mechanisms of MAIP1 in EC remain incompletely defined. Purpose. This study aims to determine the clinical significance of MAIP1 in EC and explores its potential molecular mechanisms regulating tumor immune infiltration. Methods. We obtained RNA-seq datasets and corresponding clinical data for EC patients from the Cancer Genome Atlas (TCGA) database via the UCSC Xena browser to extract MAIP1 expression and plot survival curves to determine their prognosis. Based on the differential expression of MAIP1, EC patients were divided into high and low group to investigate the mechanism of MAIP1 in EC. In addition, the single sample gene set enrichment analysis (ssGSEA) quantified the expression of various immune cell signature marker genes and assessed the degree of immune infiltration in EC. Results. In the TCGA-EC cohort, the overexpression of MAIP1 was observed in tumor tissues compared to normal tissues ( p = 0.0038 ). Overall survival analysis showed that EC patients with the overexpression of MAIP1 presented a lower overall survival and worse prognosis ( p = 0.004 ). Enrichment analysis revealed that the differential genes (DEGs) between high and low group are involved in biological functions such as extracellular matrix and organization extracellular structure. The results of ssGSEA showed that DCs, iDCs, macrophages, mast cells, and NK cells were significantly different in MAIP1high and MAIP1low groups, and all showed high expression in the MAIP1low group. Conclusion. We proposed that MAIP1 overexpression was associated with poor prognosis and tumor immune infiltration in EC. At present, there are few MAIP1-related tumor immune infiltration studies in EC, and further investigation is needed.
    Type of Medium: Online Resource
    ISSN: 2314-7156 , 2314-8861
    URL: Article
    DOI: 10.1155/2022/7282842
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2817541-4
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  • 4
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    Lie Group Solutions of Magnetohydrodynamics Equations and Their Well-Posedness
    Hindawi Limited ; 2016
    In:  Abstract and Applied Analysis Vol. 2016 ( 2016), p. 1-8
    Details
    In: Abstract and Applied Analysis, Hindawi Limited, Vol. 2016 ( 2016), p. 1-8
    Abstract: Based on classical Lie Group method, we construct a class of explicit solutions of two-dimensional ideal incompressible magnetohydrodynamics (MHD) equation by its infinitesimal generator. Via these explicit solutions we study the uniqueness and stability of initial-boundary problem on MHD.
    Type of Medium: Online Resource
    ISSN: 1085-3375 , 1687-0409
    URL: Article
    DOI: 10.1155/2016/8183079
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2064801-7
    SSG: 17,1
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  • 5
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    Validation of a HPLC/FLD Method for Quantification of Tocotrienols in Human Plasma
    Hindawi Limited ; 2015
    In:  International Journal of Analytical Chemistry Vol. 2015 ( 2015), p. 1-7
    Details
    In: International Journal of Analytical Chemistry, Hindawi Limited, Vol. 2015 ( 2015), p. 1-7
    Abstract: Quantification of tocotrienols in human plasma is critical when the attention towards tocotrienols on its distinctive properties is arising. We aim to develop a simple and practical normal-phase high performance liquid chromatography method to quantify the amount of four tocotrienol homologues in human plasma. Using both the external and internal standards, tocotrienol homologues were quantified via a normal-phase high performance liquid chromatography with fluorescence detector maintained at the excitation wavelength of 295 nm and the emission wavelength of 325 nm. The four tocotrienol homologues were well separated within 30 minutes. A large interindividual variation between subjects was observed as the absorption of tocotrienols is dependent on food matrix and gut lipolysis. The accuracies of lower and upper limit of quantification ranged between 92% and 109% for intraday assays and 90% and 112% for interday assays. This method was successfully applied to quantify the total amount of four tocotrienol homologues in human plasma.
    Type of Medium: Online Resource
    ISSN: 1687-8760 , 1687-8779
    URL: Article
    DOI: 10.1155/2015/357609
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2494714-3
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  • 6
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    Clearance of Free Silica in Rat Lungs by Spraying with Chinese Herbal Kombucha
    Hindawi Limited ; 2013
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2013 ( 2013), p. 1-9
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2013 ( 2013), p. 1-9
    Abstract: The effects of spraying with kombucha and Chinese herbal kombucha were compared with treatments with tetrandrine in a rat silicosis model. Silica dust (50 mg) was injected into the lungs of rats, which were then treated with one of the experimental treatments for a month. The rats were then killed and the effects of the treatments were evaluated by examining the extent and severity of the histopathological lesions in the animals’ lungs, measuring their organ coefficients and lung collagen contents, determining the dry and wet weights of their lungs, and measuring the free silica content of the dried lungs. In addition, lavage was performed on whole lungs taken from selected rats, and the numbers and types of cells in the lavage fluid were counted. The most effective treatment in terms of the ability to reduce lung collagen content and minimize the formation of pulmonary histopathological lesions was tetrandrine treatment, followed by Chinese herbal kombucha and non-Chinese herbal kombucha. However, the lavage fluid cell counts indicated that tetrandrine treatment had severe adverse effects on macrophage viability. This effect was much less pronounced for the kombucha and Chinese herbal kombucha treatments. Moreover, the free silica levels in the lungs of animals treated with Chinese herbal kombucha were significantly lower than those for any other silica-exposed group. These preliminary results indicate that spraying with Chinese herbal kombucha preparations can effectively promote the discharge of silica dust from lung tissues. Chinese herbal kombucha inhalation may thus be a useful new treatment for silicosis and other pneumoconiosis diseases.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2013/790792
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2148302-4
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  • 7
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    Identification of Ferroptosis-Associated Long Noncoding RNA Prognostic Model and Tumor Immune Microenvironment in Thyroid Cancer
    Hindawi Limited ; 2022
    In:  Journal of Immunology Research Vol. 2022 ( 2022-7-20), p. 1-19
    Details
    In: Journal of Immunology Research, Hindawi Limited, Vol. 2022 ( 2022-7-20), p. 1-19
    Abstract: Background. Thyroid cancer (TC) is a rapidly increasing incidence of endocrine malignancies, occupying 3% of new cancer incidence, of which 10% has a heterogeneous prognosis. Ferroptosis is a form of cell death distinct from apoptosis, which involves antitumor drug-related research. Long noncoding RNAs (lncRNAs) could affect cancer prognosis by regulating the ferroptosis; thus, ferroptosis-associated lncRNAs are emerging as prospective biomarkers for cancer therapy and prognosis. However, the prognostic factors of ferroptosis-associated lncRNAs in this solid tumor and their mechanisms remain unknown. Methods. The TC lncRNA data were extracted from RNA sequencing files of The Cancer Genome Atlas (TCGA). Then, we performed a two-cluster analysis and grouped 502 patients with TC in a 7 : 3 ratio. Both the least absolute shrinkage and selection operator (LASSO) regression and Cox regression analysis were conducted to create and validate the ferroptosis-associated lncRNA prognostic model (Ferr-LPM). Based on the median Ferr-LPM-based risk score (LPM_score) of the training cohort, we categorized patients into high and low LPM_score groups, which were then subjected to prognostic correlation and difference analysis. We also created a nomogram and assessed its predictive ability. Furthermore, immune-related mechanisms were investigated by analyzing the tumor immune microenvironment (TIME) and applying algorithms such as CIBERSROT. Results. We built a highly accurate nomogram to promote the clinical applicability of Ferr-LPM. The area under the receiver operating characteristic curve (AUC-ROC) reached above 0.9. Survival analysis suggested that when the Ferr-LPM score was higher, the overall survival (OS) of patients within this group was shorter. Meanwhile, we found a strong association between Ferr-LPM and TIME. Interestingly, the LPM_score was inversely proportional to the tumor purity but positively related to immune checkpoint blockade (ICB) response. Conclusion. We constructed a novel ferroptosis-associated lncRNA nomogram that could highly predict the prognosis of TC patients. Ferroptosis-associated lncRNAs might possess potential functions in regulating TIME, and lncRNAs provide TC patients with new prognostic biomarkers and therapeutic targets.
    Type of Medium: Online Resource
    ISSN: 2314-7156 , 2314-8861
    URL: Article
    DOI: 10.1155/2022/5893998
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2817541-4
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  • 8
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    Novel interrupted aortic arch: A case report
    Hindawi Limited ; 2022
    In:  Journal of Cardiac Surgery Vol. 37, No. 12 ( 2022-12), p. 5639-5642
    Details
    In: Journal of Cardiac Surgery, Hindawi Limited, Vol. 37, No. 12 ( 2022-12), p. 5639-5642
    Type of Medium: Online Resource
    ISSN: 0886-0440 , 1540-8191
    URL: Issue
    URL: Article
    DOI: 10.1111/jocs.v37.12
    DOI: 10.1111/jocs.17223
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2108425-7
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  • 9
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    L actobacillus plantarum WCFS1 Fermentation Differentially Affects Antioxidant Capacity and Polyphenol Content in Mung bean ( Vigna radiata ) and Soya Bean ( Glycine max ) Milks : Antioxidant Polyphenols in Fermented Bean Milks
    Hindawi Limited ; 2017
    In:  Journal of Food Processing and Preservation Vol. 41, No. 1 ( 2017-02), p. e12944-
    Details
    In: Journal of Food Processing and Preservation, Hindawi Limited, Vol. 41, No. 1 ( 2017-02), p. e12944-
    Type of Medium: Online Resource
    ISSN: 0145-8892
    URL: Issue
    URL: Article
    DOI: 10.1111/jfpp.2017.41.issue-1
    DOI: 10.1111/jfpp.12944
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2175273-4
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  • 10
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    Inhibitory effect of chitosan‐based coating on the deterioration of muscle quality of Pacific white shrimp at 4°C storage
    Hindawi Limited ; 2021
    In:  Journal of Food Processing and Preservation Vol. 45, No. 2 ( 2021-02)
    Details
    In: Journal of Food Processing and Preservation, Hindawi Limited, Vol. 45, No. 2 ( 2021-02)
    Type of Medium: Online Resource
    ISSN: 0145-8892 , 1745-4549
    URL: Issue
    URL: Article
    DOI: 10.1111/jfpp.v45.2
    DOI: 10.1111/jfpp.15167
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2175273-4
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