In:
EMBO Molecular Medicine, EMBO, Vol. 9, No. 6 ( 2017-06), p. 741-749
Kurzfassung:
image The orphan receptor endosialin ( CD 248) is expressed by activated hepatic stellate cells ( HSC ) during hepatocarcinogenesis and exerts autocrine and paracrine tumor growth‐inhibiting effects. HSC in human hepatocellular carcinoma ( HCC ) express endosialin ( CD 248). Growth of HCC in endosialin‐deficient mice is enhanced revealing a tumor‐suppressing effect of HSC during hepatocarcinogenesis. Endosialin‐silenced HSC express increased levels of HCC growth‐promoting cytokines, including IGF 2, CCL 5 and RBP 4.
Materialart:
Online-Ressource
ISSN:
1757-4676
,
1757-4684
DOI:
10.15252/emmm.201607222
Sprache:
Englisch
Verlag:
EMBO
Publikationsdatum:
2017
ZDB Id:
2485479-7
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