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  • 1
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    The association of neuropsychiatric disorders and endocrine parameters in hashimoto thyroiditis
    ECO-Vector LLC ; 2020
    In:  Pediatrician (St. Petersburg) Vol. 11, No. 4 ( 2020-12-08), p. 55-68
    Details
    In: Pediatrician (St. Petersburg), ECO-Vector LLC, Vol. 11, No. 4 ( 2020-12-08), p. 55-68
    Kurzfassung: Hashimoto thyroiditis is the most common thyroid disease. This form of pathology has a diverse clinical picture, including neuropsychiatric disorders. There are frequent cases of comorbidity of autoimmune thyroiditis and psychiatric forms of pathology, along with such a nosological entity as Hashimotos encephalopathy (aka: Steroid-responsive encephalopathy of autoimmune thyroiditis), characterized by an increased level of antithyroid autoantibodies and various mental disorders, with still unclear pathogenesis. The question arises, how to regard patients with psychiatric disorders and Hashimoto thyroiditis either as patients having autoimmune thyroiditis, comorbid with psychiatric forms of pathology, or as patients with Hashimotos encephalopathy? We studied groups of patients with autoimmune thyroiditis free from any psychiatric disorders, autoimmune thyroiditis comorbid with psychiatric forms of pathology, and a group of healthy donors similar as regards to their age and sex. We also studied medical history, clinical manifestations of the disease, instrumental data and the serum levels of thyrotropin, thyroid hormones, various antithyroid autoantibodies, and prolactin. We analyzed the correlation of laboratory and instrumental parameters and clinical data in all groups of patients. Therewas a significant relationship (p 0,05) between various psychiatric symptoms and a decreased level of free thyroxine, an increased level of thyroid stimulating hormone (TSH), an increased level of prolactin and an increased volume of a thyroid gland. Asignificant relationship (p 0,05) was also found between various symptoms of hypothyroidism and a decreased level of free triiodothyronine (FT3), an increased level of antibodies to thyroglobulin (anti-TG Ab), and an increased level of antibodies to thyroid peroxidase (anti-TPO Ab).
    Materialart: Online-Ressource
    ISSN: 2587-6252 , 2079-7850
    URL: Article
    DOI: 10.17816/PED11455-68
    Sprache: Unbekannt
    Verlag: ECO-Vector LLC
    Publikationsdatum: 2020
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  • 2
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    The metabolic logistics of stress, diabetes mellitus and works by Bernardo Alberto Houssay
    ECO-Vector LLC ; 2015
    In:  Pediatrician (St. Petersburg) Vol. 6, No. 3 ( 2015-09-15), p. 104-111
    Details
    In: Pediatrician (St. Petersburg), ECO-Vector LLC, Vol. 6, No. 3 ( 2015-09-15), p. 104-111
    Kurzfassung: The paper deals with redistribution of energetic and plastic resources in the organism during stress, acute phase response and diabetes mellitus. Assuming metabolic regulation is based upon balanced contradictory influences of diverse chemical signals (substrates, ions, autacoids, hormones, neurotransmitters, physiological autoantibodies) the peculiarities of insulin- and counter-insulin effects during acute and chronic adaptation under stress, acute phase response and diabetes mellitus have been discussed. The role of chronic stress and accompanying metabolic disorders has been accentuated as a basis for stress-associated diseases’ development. The role of outstanding Argentinean pathophysiologist Bernardo Alberto Houssay (1887-1971) is discussed. He had devoted himself to studies of pituitary bioregulators’ influence on insulin effects immediately after insulin discovery and had established in 1924 that pituitary removal is able to increase sensitivity to insulin in dogs, and developed “secondary diabetes mellitus” concept as a result of counter-insulin hormones’ excess (especially hormones of adenohypophysis and the adrenal glands (“steroid diabetes”). Bernardo Alberto Houssay was really the first to experimentally prove pituitary and adrenal bioregulators to oppose the insulin effects. Bernardo Alberto Houssay has been 46 times nominated for the Nobel prize for 17 years (1931 through 1947), and finally was awarded the Nobel prize in 1947 for achievements in Physiology and Medicine for disclosing the role of pituitary in carbohydrate metabolism (he was the first ever Nobel prize winner from Latin America). The paper discusses publications by B. A. Houssay, current development of his ideas, as well as historical and biographical information on his research and his scientific school of endocrinologists-pathophysiologists in the context of his epoch, on the background of history of Argentina [3 figs, bibliography: 34 refs].
    Materialart: Online-Ressource
    ISSN: 2587-6252 , 2079-7850
    URL: Issue
    URL: Article
    DOI: 10.17816/PED63
    DOI: 10.17816/PED63104-111
    Sprache: Unbekannt
    Verlag: ECO-Vector LLC
    Publikationsdatum: 2015
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  • 3
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    AUTOIMMUNOLOGY: NEW BRANCH OF MEDICINE
    ECO-Vector LLC ; 2017
    In:  Bulletin of the Russian Military Medical Academy Vol. 19, No. 3 ( 2017-12-15), p. 3-14
    Details
    In: Bulletin of the Russian Military Medical Academy, ECO-Vector LLC, Vol. 19, No. 3 ( 2017-12-15), p. 3-14
    Kurzfassung: The article written by the co-chairmen of the First St. Petersburg Congress on Autoimmunity "Bridge between East and West", held in St. Petersburg State University June 30-July 2, 2017 describes this event and gives an overview of the main lectures and discussions during the Congress. The latest data on the role of diet, adjuvants, vaccines, viruses and microbiome, on genetic factors, stress, smoking, lifestyle, drugs - in etiology, as well as the role of lymphocytes, macrophages, various autoantibodies, complement and cytokines - in the pathogenesis and diagnosis of autoimmune diseases were discussed. The congress discussed their comorbidity, ways of treatment and prevention, markers, methodology and contribution of serological tests in the diagnosis and classification of autoimmune diseases. Current data on physiological autoimmunity, as well as the early predictive role of autoantibodies were described. The participants performed philosophical discussions about immunological concepts, and organizational discussions of the standardization of diagnostics and the principles of working with large databases, as applied to this field. The programme included Clinical Pathophysiology все of various autoimmune rheumatologic, psycho-neurological, endocrine, cardiovascular, obstetric-gynecological and many other diseases. The authors conclude that the rapid formation of Autoimmunology as a new integral medical branch happens nowadays (9 figs, bibliography: 69 refs).
    Materialart: Online-Ressource
    ISSN: 2687-1424 , 1682-7392
    URL: Issue
    URL: Article
    DOI: 10.17816/brmma.363
    DOI: 10.17816/brmma12172
    Sprache: Unbekannt
    Verlag: ECO-Vector LLC
    Publikationsdatum: 2017
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  • 4
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    The role of hypocalcemia and vitamin D3 in pathogenesis of phobias in chronic autoimmune Hashimoto’s thyroiditis
    ECO-Vector LLC ; 2017
    In:  Pediatrician (St. Petersburg) Vol. 8, No. 4 ( 2017-08-15), p. 39-42
    Details
    In: Pediatrician (St. Petersburg), ECO-Vector LLC, Vol. 8, No. 4 ( 2017-08-15), p. 39-42
    Kurzfassung: Today, autoimmune Hashimoto´s thyroiditis is the most common cause of hypothyroidism. Thyroid hormones are involved in almost all metabolic processes, their deficiency leads to disruption of metabolic processes in all organs and systems, which is the reason for the rich clinical picture and variety of symptoms of hypothyroidism. The deficiency of thyroid hormones also has a significant negative impact on a person's mental health, identifying a diverse clinical picture – from mild disorders to serious mental disorders. For hypothyroidism, such psycho-neurological changes as drowsiness, weakness, loss of interest in the surroundings, loss of memory and intelligence are also characteristic. Delirious and delirious-hallucinatory conditions are described, as well as anxious and depressive conditions. Hypothyroid psychoneurological disorders have recently become more common, and therefore their diagnosis and correction are becoming more urgent. Persons with hypothyroi dism often mistakenly go not to the endocrinologist, but to a psychiatrist and receive therapy, but psychotropic drugs and antidepressants in hypothyroidism don´t give the proper effect and even are contraindicated. Hypocalcemia is very often observed with Hashimoto´s thyroiditis, it can be explained by autoimmune parathyroiditis with a hypoparathyroid clinic, that is, with autoimmune thyroiditis, the function of parathyroid glands may be disrupted. The article presents the results of our own research. A group of patients with autoimmune thyroiditis and hypothyroidism was examined. Complaints, anamnesis and clinic of the disease, levels of TSH, thyroid hormones, total and ionized calcium, inorganic phosphorus, vitamin D3 were studied.
    Materialart: Online-Ressource
    ISSN: 2587-6252 , 2079-7850
    URL: Issue
    URL: Article
    DOI: 10.17816/PED84
    DOI: 10.17816/PED8439-42
    Sprache: Unbekannt
    Verlag: ECO-Vector LLC
    Publikationsdatum: 2017
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
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    Anthropogenic environmental factors as triggers of type 1 diabetes mellitus in children
    ECO-Vector LLC ; 2020
    In:  Pediatrician (St. Petersburg) Vol. 11, No. 2 ( 2020-06-08), p. 57-65
    Details
    In: Pediatrician (St. Petersburg), ECO-Vector LLC, Vol. 11, No. 2 ( 2020-06-08), p. 57-65
    Kurzfassung: In the 21st century, environmental factors of anthropogenic origin began to come under the close attention of scientists. There is an increase in the incidence of various nosological forms, with autoimmune pathogenesis. Among them, one of the most important endocrinopathies is type 1 diabetes mellitus (DM1), especially in children. In parallel, the urban population continues to grow. At the same time, up to 60% of the urban population of Russia (about 58.8 million people) lives in areas with high and very high levels of environmental pollution. Among the pollution factors, special attention is now drawn to the car and road complex, during the operation of which destruction aerosols are formed, forming a mixture of particles that includes a chemical composition of a mixture of silicon oxides, aluminum, iron, calcium, magnesium and organic substances, as well as compounds with heavy metals. The article analyzes the main sources of environmental pollution in Russian Federation, identifies the central/dominant model, and predicts significant and secondary models of possible regional correlation between the factors related to urbanization and spread of an autoimmune disease, which is DM1 among children of Russia.
    Materialart: Online-Ressource
    ISSN: 2587-6252 , 2079-7850
    URL: Article
    DOI: 10.17816/PED11257-65
    Sprache: Unbekannt
    Verlag: ECO-Vector LLC
    Publikationsdatum: 2020
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
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    Experimental modeling of behavioral disorders accompanying hashimoto’s thyroiditis by means of specific immunoglobulins
    ECO-Vector LLC ; 2021
    In:  Pediatrician (St. Petersburg) Vol. 12, No. 3 ( 2021-10-13), p. 31-41
    Details
    In: Pediatrician (St. Petersburg), ECO-Vector LLC, Vol. 12, No. 3 ( 2021-10-13), p. 31-41
    Kurzfassung: Among the manifestations of Hashimotos autoimmune thyroiditis, there are various psychoneurological disorders. For more than a century, it has been known about psycho-neurological disorders associated with hypothyroidism, but along with that, there are also mental disorders in patients with thyropathies in euthyroid state. In 1966, Hashimotos encephalopathy was described, the pathogenesis and clear differential diagnostic criteria of which have not yet been determined. This article describes an experimental study in laboratory mice with intracisternal stereotaxic injection of IgG isolated from patients with autoimmune thyroiditis and comorbid depression or schizophrenia. A control group included animals receiving polyclonal IgG from healthy donors. Then behavioral tests were carried out, which revealed the characteristics and changes in behavior in the operated animals. Thus, animals that received immunoglobulins from patients with autoimmune thyroiditis and depression were less active in relation to the development of risk behavior. Porsolts tests on the 4th and 15th days after surgery showed that, regardless of the kind of the injected solutions, there was a change in the temporal relationships between the behavior patterns. In mice received IgG from patients with autoimmune thyroiditis and schizophrenia during the delayed Porsolt test, the ratio of the forms of motor activity shifted towards passive swimming. The mice received IgG from healthy donors did not demonstrate this change.
    Materialart: Online-Ressource
    ISSN: 2587-6252 , 2079-7850
    URL: Article
    DOI: 10.17816/PED12331-41
    Sprache: Unbekannt
    Verlag: ECO-Vector LLC
    Publikationsdatum: 2021
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  • 7
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    Comparative aetio-epidemiological analysis of lung tuberculosis versus sarcoidosis: classical and new concepts
    ECO-Vector LLC ; 2020
    In:  Pediatrician (St. Petersburg) Vol. 11, No. 5 ( 2020-12-30), p. 37-50
    Details
    In: Pediatrician (St. Petersburg), ECO-Vector LLC, Vol. 11, No. 5 ( 2020-12-30), p. 37-50
    Kurzfassung: The review presents data on two similar granulomatous inflammatory diseases: tuberculosis and sarcoidosis of the lungs, which together cover about 5% of all pulmonary pathology, albeit occur with different incidence (20 : 1). Despite the established aetiology of tuberculosis, the disease has not disappeared and nowadays has even acquired a new urgency: It is getting out of control due to growing poverty, the comorbidity with HIV infection, increasing cases of drug resistance of Mycobacteria, insufficient effectiveness and the growing costs of its treatment. Against the background of the expansion of anthropogenic influences and other environmental impacts on the immune system, the incidence of lung sarcoidosis is also increasing, while patients are initially often misdiagnosed with tuberculosis, with resulting unjustified anti-tuberculosis chemotherapy, leading to chronization of the disease with frequent relapses and, accordingly, to an increase in disability and mortality rates. In recent years, clinical manifestations of sarcoidosis due to a variety of trigger aetiological factors with adjuvant-like action (from Mycobacteria to xenobiotics) are considered by a number of authors as a variant of autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA). The article emphasizes the similarity of two granulomatous inflammatory diseases and the concept of two variants of the bodys response to similar or even identical aetiological factors within different human reactivity (possibly on a different mosaic/permissive background). In brief the newest data on experimental models of sarcoidosis are reviewed as well as the role of autophagy disorders and opposite macrophageal polarization in tuberculosis versus sarcoidosis. Authors coined the original hypothesis of the possible therapeutic effectiveness of Rapamycin in sarcoidosis and for the first time posed a question of equivocal character of comorbidity between these granulomatoses and COVID-19 infection.
    Materialart: Online-Ressource
    ISSN: 2587-6252 , 2079-7850
    URL: Article
    DOI: 10.17816/PED11537-50
    Sprache: Unbekannt
    Verlag: ECO-Vector LLC
    Publikationsdatum: 2020
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