Publikationsdatum:
2018-05-16
Beschreibung:
Objective: Extranodal extension in cervical lymph nodes is an important risk factor for the progression and prognosis of papillarythyroid cancer. The purpose of this study was to identify the common and characteristic preoperative ultrasonography featuresthat are associated with the pathologic extranodal extension of metastatic papillary thyroid carcinoma. Methods: We retrospectively assessed and compared clinicopathologic and ultrasound features between 60 papillary thyroidcancer patients with extranodal extension and 120 control patients with papillary thyroid cancer without extranodal extension. Results: With respect to the pathological N stage and clinicopathologic features, N1b stage papillary thyroid carcinomas weremore frequently found in patients who were extranodal extension-positive, in comparison with those who were extranodalextension-negative (78.3% vs. 63.3%, P=0.043). Extranodal extension was detected most frequently in level VI cervical lymphnodes (48.7%). In our univariate analysis of patients with papillary thyroid carcinoma, cervical lymph nodes with extranodalextension showed higher incidences of node matting, microcalcification, cystic area, aspect ratio 〈2, and larger diameter thanthose without extranodal extension (all P〈0.05). Our multivariate analysis demonstrated that node matting and cystic area wereindependent risk factors for the presence of extranodal extension [odds ratio (OR): 4.751, 95% confidence interval (CI):1.212~18.626, P=0.025; OR: 2.707, 95% CI: 1.127~6.502, P=0.026]. Conclusions: Common ultrasound features may indicate the presence of extranodal extension in patients with metastatic cervicallymph nodes of papillary thyroid carcinoma.
Digitale ISSN:
2095-3941
Thema:
Medizin
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