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  • 1
    Electronic Resource
    Electronic Resource
    Glutamate receptor 1-immunopositive neurons in the gliotic CA1 area of the mouse hippocampus after pilocarpine-induced status epilepticus (2005)
    Oxford, UK : Blackwell Science Ltd
    European journal of neuroscience 21 (2005), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Significant reduction in glutamate receptor 1 (GluR1)- and GluR2/3-immunopositive neurons was demonstrated in the hilus of the dentate gyrus in mice killed on days 1, 7 and 60 after pilocarpine-induced status epilepticus (PISE). In addition, GluR1 and GluR2/3 immunostaining in the strata oriens, radiatum and lacunosum moleculare of areas CA1–3 decreased drastically on days 7 and 60 after PISE. Neuronal loss observed in the above regions may account, at least in part, for a decrease in GluR immunoreactivity. By contrast, many GluR1-immunopositive neurons were observed in the gliotic area of CA1. Of these, about 42.8% were immunopositive for markers for hippocampal interneurons, namely calretinin (7.6%), calbindin (12.8%) and parvalbumin (22.4%). GluR1 or GluR2/3 and BrdU double-labelling showed that the GluR1- and GluR2/3-immunopositive neurons at 60 days after PISE were neurons that had survived rather than newly generated neurons. Furthermore, anterograde tracer and double-labelling studies performed on animals at 60 days after PISE indicated a projection from the hilus of the dentate gyrus to gliotic areas in both CA3 and CA1, where the projecting fibres apparently established connections with GluR1-immunopositive neurons. The projection to CA1 was unexpected. These novel findings suggest that the intrinsic hippocampal neuronal network is altered after PISE. We speculate that GluR1-immunopositive neurons in gliotic CA1 act as a bridge between dentate gyrus and subiculum contributing towards epileptogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1460-9568.2005.04071.x
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  • 2
    Electronic Resource
    Electronic Resource
    Osmolality and ion balance in giant river prawn Macrobrachium rosenbergii subjected to changes in salinity: role of sex (2003)
    Oxford, UK : Blackwell Science Ltd
    Aquaculture research 34 (2003), S. 0 
    Details
    ISSN: 1365-2109
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Haemolymph osmolality, chloride and sodium concentrations of giant river prawn Macrobrachium rosenbergii adults were determined 15 days after they were transferred from freshwater to 0 (control), 7, 14 and 21‰ salinity. Haemolymph osmolality, chloride and sodium concentrations of prawns transferred to 7, 14 and 21‰ reached a constant level within 0.5, 2 and 3 days respectively. Both male and female adults exhibited strongly hyper-osmotic and hyper-ionic over the range of 0–14‰. The isosmotic point was 14.5 and 15.6‰, the iso-ionic point of chloride was 14.5 and 14.7‰, and the iso-ionic point of sodium was 16.5 and 15.7‰ for males and females respectively. The adults lost their hyper-regulatory ability and became osmo-conformic over the media of 14.5–21‰ and 15.6–21‰ and ion-conformic with respect to sodium over the media of 16.5–21‰ and 15.7–21‰ for males and females respectively. The adults displayed hypo-ionic to the media at 21‰ with respect to chloride.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2109.2003.00853.x
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