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  • 1
    Electronic Resource
    Electronic Resource
    Oxford UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 15 (2001), S. 0 
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Recent epidemiological, clinical and molecular studies have provided strong evidence that inherited predisposition is important in the pathogenesis of chronic inflammatory bowel diseases. The model most consistent with the epidemiological data suggests that Crohn’s disease and ulcerative colitis are related polygenic diseases, sharing some but not all susceptibility genes. Investigators throughout the world have applied the complementary techniques of genome-wide scanning and candidate gene analysis. Four areas of linkage have been widely replicated on chromosomes 16 (IBD1), 12 (IBD2), 6 (IBD3—the HLA region), and most recently on chromosome 14. Fine mapping of these regions is underway. Of the ‘positional’ candidate genes, most attention has centred on the genes of the major histocompatibility complex. Genes within this region may determine disease susceptibility, behaviour, complications and response to therapy. Hope continues that studies of inflammatory bowel disease genetics will provide fresh insight into disease pathogenesis and soon deliver clinical applications.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Aquaculture research 31 (2000), S. 0 
    ISSN: 1365-2109
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: The effect of increasing fish loading (decreasing water exchange rate, while holding fish stocking density constant) on growth, survival and feed conversion ratio was determined for two size groups of the orange-spotted grouper Epinephelus coioides (Hamilton). Fingerlings (124.3–145.8 g initial body weight) and subadults (990.6–1147.1 g initial body weight) were reared in 1-m3 circular tanks for 14 weeks. For the fingerlings experiment, three loading rates of 0.5, 2 and 6 kg L−1 min−1 were used, while in the experiment with subadults, the loading rates were 1, 3 and 6 kg L−1 min−1. The mean growth rate of fingerlings ranged from 1.60 to 2.14 g fish−1 day−1, and survival was high (95–100%); however, there were no significant differences (P 〉 0.05) as a result of the different loading rates. Similar results were obtained in the subadults experiment, in which the growth rate (3.10–4.90 g fish−1 day−1) and survival (86.7–100%) were not significantly (P 〉 0.05) affected by the different loading rates. In both experiments, the feed conversion ratios were also not affected significantly by the loading rates. These results show that water exchange in aerated, flowthrough tanks can be reduced to as low as 6 kg L−1 min−1 without adversely affecting growth, survival and feed conversion of fingerling and subadult groupers.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 17 (2003), S. 0 
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: Crohn's disease affects people world-wide, but the incidence in Asia is lower than in Western countries. This difference may be due to genetic and/or environmental factors. Three single nucleotide polymorphisms (SNPs) of the NOD2/CARD15 gene have been identified to be independently associated with the development of Crohn's disease in Caucasians. Whether these SNPs are involved in the pathogenesis of Crohn's disease in the Chinese population is unknown.Aim: To determine if NOD2/CARD15 gene polymorphisms are found in Chinese patients with Crohn's disease.Methods: Sixty-five consecutive Chinese Crohn's disease patients had genotyping performed using sequence-specific PCR directed against the wild-type and the Arg702Trp, Gly908Arg and 3020insC variants of the NOD2/CARD15 gene. Controls consisted of 63 patients with ulcerative colitis and 70 patients with dyspepsia.Results: None of the patients with Crohn's disease had heterozygous or homozygous SNP variants. Similarly none of the ulcerative colitis or dyspeptic controls had these SNPs.Conclusion: The three previously described SNPs associated with the development of Crohn's disease in Caucasians are not found in Chinese patients with Crohn's disease.
    Type of Medium: Electronic Resource
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