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  • 1
    Electronic Resource
    Electronic Resource
    Transient Overmodification of Collagen I and III in a Hyperplastic Callus from a Patient with Osteogenesis Imperfecta Type IV (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 580 (1990), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1990.tb17987.x
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  • 2
    Electronic Resource
    Electronic Resource
    EFFECTIVENESS OF PROBATION CASELOAD SIZES: A Review of the Empirical Literature (1971)
    Oxford, UK : Blackwell Publishing Ltd
    Criminology 8 (1971), S. 0 
    Details
    ISSN: 1745-9125
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Law
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1745-9125.1971.tb00750.x
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  • 3
    Electronic Resource
    Electronic Resource
    Role of the Cardiac Sarcolemmal Na+-Ca2+ Exchanger in End-Stage Human Heart Failure (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 779 (1996), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1996.tb44833.x
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  • 4
    Electronic Resource
    Electronic Resource
    Sulphide tolerance and adaptation in the California killifish, Fundulus parvipinnis, a salt marsh resident (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 42 (1993), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Hydrogen sulphide is a toxicant naturally produced in hypoxic marine sediments, hydrocarbon and brine seeps and hydrothermal vents. The California killifish, a salt marsh resident, is remarkably tolerant of sulphide. The 50% lethal concentration is 700 μM total sulphide in 96 h, and 5 mM in 8 h (determined in flow-through, oxygenated sea water). Killifish exposed to sulphide produce thiosulphate which accumulates in the blood. The cytochrome c oxidase (a major site of toxicity) of the killifish is 50% inhibited by 〈1 μM sulphide. Killifish liver mitochondria are poisoned by 50–75 μM sulphide but can oxidize 10–20 μM sulphide to thiosulphate. Sulphide causes sulphhaemoglobin formation (and impairment of oxygen transport) at 1–5 mM in vitro and to a small extent at 2 mM in vivo. Killifish blood neither catalyses sulphide oxidation significantly nor binds sulphide at environmental (low) sulphide concentrations. Exposure to 200 μM and 700 μM sulphide over several days causes significant increases in lactate concentrations, indicating shift to anaerobic glycolysis. However, individuals with the most lactate die. In terms of diffusible H2S, the killifish can withstand concentrations two to three orders of magnitude greater than would poison cytochrome c oxidase. The high sulphide tolerance of the killifish, particularly of concentrations typical of salt marshes, can be explained chiefly by mitochondrial sulphide oxidation. Sulphide tolerance and mitochondrial sulphide oxidation in the killifish have a constitutive basis, i.e. do not diminish in fish held in the laboratory in sulphide-free water for 1–2 months, and are improved by prior acclimation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1095-8649.1993.tb00381.x
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  • 5
    Electronic Resource
    Electronic Resource
    Provocative Testing in Children with Suspect Congenital Long QT Syndrome (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of noninvasive electrocardiology 3 (1998), S. 0 
    Details
    ISSN: 1542-474X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This study was designed to evaluate several alternative ECG measurements and provocative tests in order to identify markers for children with suspect congenital long QT syndrome (LQTS).〈section xml:id="abs1-2"〉〈title type="main"〉BackgroundA single QTc measurement on a resting ECG does not identify all children with LQTS. Alternative ECG measurements have been established for identification of LQTS patients, with varied degrees of accuracy. Additionally, findings of QT prolongation during exercise or catecholaminergic stimulation have been suggested as indicators for the presence of LQTS and associated arrhythmias.〈section xml:id="abs1-3"〉〈title type="main"〉MethodsThe ECGs from 40 children with suspect congenital LQTS were compared with 1000 gender and age matched control patients. Complete exercise ECG studies were performed on 32 of the 40 suspect LQTS patients and compared with 29 controls. ECGs recorded during isoproterenol infusion were obtained in 9 suspect LQTS patients and compared with 44 matched control subjects.〈section xml:id="abs1-4"〉〈title type="main"〉ResultsDuring exercise, the QTc was mildly prolonged in both groups, without a similar increase in JTc, suggesting prolongation of depolarization time. QT and JT dispersion shortened with exercise in control subjects, but not in the suspect LQTS patients. During isoproterenol infusion, the QTc and JTc are prolonged in the suspect LQTS group, without an increase in the control patients.〈section xml:id="abs1-5"〉〈title type="main"〉ConclusionsWe describe the ECG findings with provocative testing in patients in whom there is a clinical suspicion of LQTS, yet have a normal or borderline QTc. Exercise or isoproterenol may aid in identification of patients with congenital long QT syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1542-474X.1998.tb00023.x
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of Multisite Ventricular Pacing on Cardiac Function in Normal Dogs and Dogs with Heart Failure (1999)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cardiovascular electrophysiology 10 (1999), S. 0 
    Details
    ISSN: 1540-8167
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Multisite Ventricular Pacing in Heart Failure. Introduction: We studied the effects on cardiac function of pacing two right and two left ventricular sites in normal and failing hearts with a normal QRS duration. Methods and Results: Hemodynamic parameters were studied in isoflurane-anesthetized dogs with normal hearts and dogs with heart failure induced by rapid ventricular pacing. Unipolar intramyocardial electrodes were placed at the high right atrium and the apex (A) and base (B) of the left (L) and right (R) ventricles (V). Data were collected after pacing for 5 to 20 minutes. In normal dogs, without bundle branch block (BBB), pacing at either the apex or the base of the left ventricle increased cardiac output by approximately 10% compared with right ventricular apex (RVA) pacing with an AV delay of 10 msec. Positive dP/dt increased approximately 10% during four-site left and right ventricular apex and base (LRVAB) pacing compared with RVA pacing. In dogs with heart failure but without BBB, cardiac output increased by 8.5% (P 〈 0.01) during four-site ventricular pacing with AV delays of 0 and 60 msec compared with RVA pacing. Positive dp/dt increased by 23.5% (P 〈 0.001) with an AV delay of 0 msec and 9.6% (P 〈 0.001) with an AV delay of 60 msec during LRVAB pacing compared with RVA pacing. His-bundle pacing was associated with increased cardiac output compared with RVA pacing. Conclusions: We conclude that pacing simultaneously at two right and two left ventricular sites significantly improves cardiac function compared with single RVA pacing, with or without sequential AV synchrony, in dogs with rapid ventricular pacing-induced heart failure and no BBB.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-8167.1999.tb01264.x
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  • 7
    Electronic Resource
    Electronic Resource
    VERTICAL HETEROGENEITY AND MOVEOUT IN THE ONE-DIMENSIONAL MEDIUM (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Geophysical prospecting 35 (1987), S. 0 
    Details
    ISSN: 1365-2478
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences , Physics
    Notes: Since the important contributions of Dürbaum and Dix, 30 years ago, velocity profile estimation procedures on horizontally layered and vertically heterogeneous media from seismic probing data have been based largely on hyperbolic moveout models and RMS and stacking velocity concepts. Re-examination of the fundamentals reveals that quantitative velocity heterogeneity and canonical valocity profiles have been implicit factors for moveout modelling and for profile inversion in the use of the Dix procedure. Heterogeneity h is the ratio (and vRMS the geometric or harmonic mean) of the path-average and time-average velocities for a raypath or, in a more restricted sense, for the normal ray belonging to a velocity profile. The canonical profile for a given velocity profile or profile segment is a moveout-equivalent monotonically increasing ramp-like profile.The ramp or constant gradient in depth is the simplest velocity profile approximator which can explicitly accommodate velocity heterogeneity. A ramp model structure is detailed which facilitates moveout simulation and model parameter estimation, and the parametric effects are explored. The horizontal offset range is quantified for which this model can give good moveout approximations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2478.1987.tb00845.x
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  • 8
    Electronic Resource
    Electronic Resource
    A FORWARD GENERATED SYNTHETIC SEISMOGRAM FOR EQUAL-DELAY LAYERED MEDIA MODELS (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Geophysical prospecting 29 (1981), S. 0 
    Details
    ISSN: 1365-2478
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences , Physics
    Notes: A forward solution for the reflection response of a parallel stratified lossless medium characterized by discrete reflection coefficients and unequal layer delays, for a normally incident pressure source signal, is presented. The notation, which details the reflection history of each wavelet in a response record, facilitates systematic enumeration of all terms in the reflection impulse response model, the determination of compact closed form expressions for amplitudes and delays of multiply reflected wavelets, and the aggregation of dynamic analog groups. An equal delay time constraint on layer thicknesses leads then to the reflection sequence or synthetic seismogram structure as an infinite sum of wavelets by their order of reflection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2478.1981.tb01019.x
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  • 9
    Electronic Resource
    Electronic Resource
    Inheritance of sesquiterpene lactone types within the Achillea millefolium complex (Compositae) (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Plant breeding 116 (1997), S. 0 
    Details
    ISSN: 1439-0523
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Successful crossing experiments between tetraploid individuals of Achillea ceretanica, A. collina, A. distans ssp. styriaca, and A. pratensis (A. millefolium complex, Compositae) were carried out. Sesquiterpenes of 1013 hybrid plants obtained from 13 crossings were studied by qualitative thin layer chromatography (TLC). F1-progenies from parent plants with guaianolides (GU-type), as well as the offspring of a back-cross, uniformly contained proazulenes. Diallel crosses between plants exclusively with eudesmanolides (EU-type) resulted in a 7:1 segregation-ratio of EU- and GU-plants. Two reciprocal crossing experiments between EU- and GU-parents resulted in 28.6% and 89.3% EU-individuals, as well as GU-offspring. According to these findings, the qualitative marker ‘proazulene’ (GU-type) is thought to be a recessive character of the tetraploid Achillea species studied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1439-0523.1997.tb00979.x
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  • 10
    Electronic Resource
    Electronic Resource
    Low Temperature and Low Energy Radiofrequency Modification of Atrioventricular Nodal Slow Pathways in Pediatric Patients (1999)
    Oxford, UK : Blackwell Publishing Ltd
    Pacing and clinical electrophysiology 22 (1999), S. 0 
    Details
    ISSN: 1540-8159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objectives: To report our experience using low temperature and energy in the modification of the slow pathway in pediatric patients with atrioventricular nodal reentrant tachycardia. Background: A concern in performing a slow pathway modification is the possible damage of the normal AV conduction system. Lesion size has been shown to have a linear relationship with temperature. Previous reports have used energy of 25–50 W that generate temperatures of 60C°–70°C for successful procedures. Methods: Report of results of attempted AV nodal slow pathway modification in 17 consecutive pediatric patients 〈 15 years of age at The Children's Hospital of Philadelphia from April 1995 to November 1997 using low temperature and energy. Results: There were 18 successful slow pathway modifications with 1 recurrence in 17 patients. The maximum energy used during successful lesions was 32.7 ± 13.8 W (range 15–50 W) with a mean energy of 26.4 ± 13.3 W (range 12–48 W). The peak temperature during these lesions was 55.1°C ± 4.1°C (range 48°C–64°C) with a mean temperature of 47.9°C ± 2.7°C (range 44°C–54°C). The mean number of radiofrequency lesions required for a successful modification was 5.8 ± 6.7 (median 4.0, range 1–26). Patients have been followed for 2.08 ± 0.79 years. Conclusions: Slow pathway modification can be performed successfully with a low incidence of recurrence in the pediatric patient using low energy and temperature. It is possible that this may lead to smaller lesions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-8159.1999.tb00572.x
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