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  • Bentham Science Publishers Ltd.  (5)
  • 1
    Online Resource
    Online Resource
    Secondary Metabolites of Plant Origin Containing Carbazole as Lead Molecule: A Review
    Bentham Science Publishers Ltd. ; 2021
    In:  Current Traditional Medicine Vol. 7, No. 1 ( 2021-02-04), p. 57-71
    Details
    In: Current Traditional Medicine, Bentham Science Publishers Ltd., Vol. 7, No. 1 ( 2021-02-04), p. 57-71
    Abstract: The continuous attempt of drug discovery and search for a potential drug molecules with promising pharmacological activities is always of immense interest. Most of those chemical compounds having active pharmacological effects contain heterocyclic nucleus or compounds. Heterocyclic compounds clutch a particular place among pharmaceutically active natural and synthetic compounds. The ability to serve both as biomimetics and reactive pharmacophores of the heterocyclic nucleus is incredible and principally contributed to their unique value as traditional key elements of many drugs. These heterocyclic nuclei offer a huge area for new lead molecules in drug discovery and for the generation of activity relationships with biological targets to enhance their pharmacological effects. In the heterocyclic nucleus, the hydrogen bond acceptors and donors arranged in a manner of a semi-rigid skeleton in heterocyclic rings and therefore can present a varied display of significant pharmacophores. Lead identification and optimization of a probable drug target can be achieved by the generation of chemically diverse heterocyclic pharmacophores with different groups or substituents. Herein, an attempt is made to review and summarize the naturally occurring carbazole containing alkaloids obtained from Murraya, Causena and Glycosmis species and their potential towards anticancer activity. Carbazole is a tricyclic heterocyclic molecule and an integral part of naturally occurring alkaloids possessing various potential biological activities such as anticancer, antimicrobial and antiviral. Due to the high binding affinity of carbazole towards nucleic acid/ receptor and mimicking their biological activity, carbazole derived alkaloids exhibit the potential cytotoxic effect.
    Type of Medium: Online Resource
    ISSN: 2215-0838
    URL: Article
    DOI: 10.2174/2215083805666190617110019
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2021
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Role of Plant-Derived Products Through Exhilarating Peroxisome Proliferator-Activated Receptor-γ (ppar-γ) in the Amelioration of Obesity Induced Insulin Resistance
    Bentham Science Publishers Ltd. ; 2022
    In:  Current Nutrition & Food Science Vol. 18, No. 6 ( 2022-07), p. 549-558
    Details
    In: Current Nutrition & Food Science, Bentham Science Publishers Ltd., Vol. 18, No. 6 ( 2022-07), p. 549-558
    Abstract: Insulin resistance is an elemental facet of the etiology of diabetes mellitus and the principal relating factor between obesity and diabetes. Oxidative stress, lipotoxicity, inflammation and receptor dysfunction are the underlying determinants of insulin resistance commencement in metabolic illnesses. ppar-γ is a nuclear transcription factor whose activation or inhibition directly influences insulin resistance and controls glucose and lipid homeostasis by modulating gene expression. Synthetic ligands of ppar-γ are therapeutically employed to counter the hyper-glycaemia associated with obesity and type 2 diabetes, but they possess severe side effects. In the modern era, bioactive phytochemicals have been employed in the drug development process and a considerable investigation has recently been initiated to analyze the ppar-γ activating ability of diverse phytochemicals. In this review, we outlined the role of phytochemicals in insulin resistance treatment through ppar-γ activation.
    Type of Medium: Online Resource
    ISSN: 1573-4013
    URL: Article
    DOI: 10.2174/1573401318666220217111415
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2022
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  • 3
    Online Resource
    Online Resource
    3D-QSAR Study on Ring Substituted Imidazoles for Their Antitubercular Activity
    Bentham Science Publishers Ltd. ; 2010
    In:  Letters in Drug Design & Discovery Vol. 7, No. 2 ( 2010-02-01), p. 128-132
    Details
    In: Letters in Drug Design & Discovery, Bentham Science Publishers Ltd., Vol. 7, No. 2 ( 2010-02-01), p. 128-132
    Type of Medium: Online Resource
    ISSN: 1570-1808
    URL: Article
    DOI: 10.2174/157018010790225912
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2010
    SSG: 15,3
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  • 4
    Online Resource
    Online Resource
    Lipase Inhibition and Amelioration of High-fat Diet-induced Obesity Potential of Cajanus Cajan (Pigeon pea) Seeds: A legume Used by Foumban and Dschang Localities of Cameroon
    Bentham Science Publishers Ltd. ; 2023
    In:  Current Nutrition & Food Science Vol. 19 ( 2023-06-26)
    Details
    In: Current Nutrition & Food Science, Bentham Science Publishers Ltd., Vol. 19 ( 2023-06-26)
    Abstract: High-calorie intake and an unbalanced lifestyle are the two foremost determinants of obesity incipience. Devising new pharmaceutical molecules with low adverse events is a challenging task. Herbal medicinal plants are safer drugs and offer plenty of nutritional and therapeutic benefits. Background: Cajanus cajan seeds are traditionally used by the Foumban and Dschang localities of Cameroon in the management of obesity. No scientific study depicting the role of this plant in obesity management has been reported yet. Aim: Present study was undertaken to evaluate the anti-obesity effect of seeds extract of C.cajan. Methods: Anti-obesity activity of seeds extract of C.cajan. was studied by in-vitro and in-vivo methods. Phytochemical screening was also performed to ascertain the presence of secondary metabolites in the extract. In-vitro lipase inhibition assay was performed using porcine pancreatic lipase enzyme in various concentrations (100-500µg/ml). In the in-vivo model, obesity was induced by a high-fat diet and seeds extract was administered orally at doses of 200 and 400 mg/kg for 4 weeks. Results: Phytochemical screening reported the presence of carbohydrates, tannins, alkaloids, phenolic compounds, glycosides, and flavonoids. Seeds extract inhibited lipase enzyme in a dose-dependent manner with IC50 value 205.28µg. The extract showed a decline in weight gain, diminished hyperlipidaemia and restored hepatic biochemistry. Conclusion: C. cajan seed extract possesses anti-obesity effects, which might be due to lipase inhibitory effects.
    Type of Medium: Online Resource
    ISSN: 1573-4013
    URL: Article
    DOI: 10.2174/1573401319666230626123700
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2023
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  • 5
    Online Resource
    Online Resource
    A Comprehensive Review on Niosomes as a Tool for Advanced Drug Delivery
    Bentham Science Publishers Ltd. ; 2023
    In:  Pharmaceutical Nanotechnology Vol. 11 ( 2023-07-26)
    Details
    In: Pharmaceutical Nanotechnology, Bentham Science Publishers Ltd., Vol. 11 ( 2023-07-26)
    Abstract: Over the past few decades, advancements in nanocarrier-based therapeutic delivery have been significant, and niosomes research has recently received much interest. The self-assembled nonionic surfactant vesicles lead to the production of niosomes. The most recent nanocarriers, niosomes, are self-assembled vesicles made of nonionic surfactants with or without the proper quantities of cholesterol or other amphiphilic molecules. Because of their durability, low cost of components, large-scale production, simple maintenance, and high entrapment efficiency, niosomes are being used more frequently. Additionally, they enhance pharmacokinetics, reduce toxicity, enhance the solubility of poorly water-soluble compounds, & increase bioavailability. One of the most crucial features of niosomes is their controlled release and targeted diffusion, which is utilized for treating cancer, infectious diseases, and other problems. In this review article, we have covered all the fundamental information about niosomes, including preparation techniques, niosomes types, factors influencing their formation, niosomes evaluation, applications, and administration routes, along with recent developments.
    Type of Medium: Online Resource
    ISSN: 2211-7385
    URL: Article
    DOI: 10.2174/2211738511666230726154557
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2023
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