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  • 1
    Online Resource
    Online Resource
    Bentham Science Publishers Ltd. ; 2020
    In:  Current Diabetes Reviews Vol. 16, No. 5 ( 2020-05-12), p. 471-482
    In: Current Diabetes Reviews, Bentham Science Publishers Ltd., Vol. 16, No. 5 ( 2020-05-12), p. 471-482
    Abstract: To determine the prevalence of, and factors associated with, people with foot deformities, among patients with diabetes in Jordan. Methods: A cross-sectional study was conducted on 1000 diabetic participants recruited from the National Center for Diabetes, Endocrinology, and Genetics in Jordan. Participants had their feet clinically examined to detect the following foot deformity outcomes: Hallux valgus, claw/hammer toe, prominent metatarsal heads, limited joint mobility, pes cavus, Charcot foot, and amputations. Sociodemographic and health variables were also collected from participants’ interviews, medical records, or clinical examination. Logistic regression was used to analyse associations between variables and each foot deformity outcome. Results: Of the 1000 diabetic patients: Hallux valgus was found in 17.4%, claw\hammer toe in 16%, prominent metatarsal head in 14.2%, limited joint mobility in 9.4%, pes cavus in 3.2%, Charcot foot in 2.1%, and amputations in 1.7%. Hallux valgus was associated with gender (p=0.012), age (p 〈 0.01) and shoe choices (p=0.031); claw\hammer toe was associated with age (p=0.04), retinopathy (p 〈 0.001), sensory and painful neuropathy (p 〈 0.001); limited joint mobility was associated with age only (p=0.001); Charcot foot was associated with glycemic control (p=0.016), hypertension (p 〈 0.000), sensory neuropathy (p 〈 0.001), and painful neuropathy (p 〈 0.001); and, amputations were associated with duration of diabetes (p 〈 0.043), sensory neuropathy (p=0.001), and painful neuropathy (p=0.001). Conclusion: Prevalence of different foot deformities in Jordan variedbetween 1.7% - 17.4%. Sociodemographic factors such as age, gender and shoes choices or presence of diabetes-related microvascular complications (neuropathy and retinopathy) or hypertension were independently associated with foot deformities among the Jordanian diabetic population.
    Type of Medium: Online Resource
    ISSN: 1573-3998
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2020
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  • 2
    Online Resource
    Online Resource
    Bentham Science Publishers Ltd. ; 2021
    In:  Current Reviews in Clinical and Experimental Pharmacology Vol. 16, No. 3 ( 2021-09-22), p. 281-288
    In: Current Reviews in Clinical and Experimental Pharmacology, Bentham Science Publishers Ltd., Vol. 16, No. 3 ( 2021-09-22), p. 281-288
    Abstract: The use of statins to lower high serum cholesterol levels may be associated with a number of adverse reactions, including severe myopathy. The solute carrier organic anion transporter 1B1 (SLCO1B1) gene, which encodes the organic anion-transporting polypeptide OATP1B1, is related to the intracellular transport of statins. The aim of this research was to study the association of rs2306283 and rs4149056 genetic polymorphism of the SLCO1B1 gene with the development of statin-induced myopathy in Jordanian diabetics receiving statins. Methods: We included 413 patients attending the Diabetes Clinics of the National Center for Diabetes, Endocrinology and Genetics, Amman, Jordan. The study was approved by the Institutional Review Board of NCDEG. Myopathy was defined as the elevation of creatine kinase more than 3 times the upper limit of normal. Every subject signed an informed consent form and donated 3-5 mL of venous blood. Genome DNA was extracted from lymphocytes of peripheral blood. Genotypes were identified using the Tetra Amplification Refractory Mutation System of SLCO1B1. Results: The minor allele frequencies of rs2306283 [G] and rs4149056 [C] were 0.38 and 0.23, respectively. The two SNPs followed the Hardy-Weinberg equilibrium. The development of SIM was significantly associated with the homozygous and heterozygous minor allele genotype of rs4149056 (CC and CT), and the homozygous wild type allele genotype of rs2306283 (AA). There was no linkage disequilibrium between the two SNPs in the studied subgroups. Conclusions: Genetic polymorphism in the SLCO1B1 Gene is a risk factor for the development of SIM in Jordanian patients.
    Type of Medium: Online Resource
    ISSN: 2772-4328
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2021
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  • 3
    Online Resource
    Online Resource
    Bentham Science Publishers Ltd. ; 2020
    In:  Current Diabetes Reviews Vol. 16, No. 5 ( 2020-05-12), p. 483-489
    In: Current Diabetes Reviews, Bentham Science Publishers Ltd., Vol. 16, No. 5 ( 2020-05-12), p. 483-489
    Abstract: This study aimed to determine the prevalence of insulin resistance among women with polycystic ovary syndrome (PCOS), describe the clinical and biochemical characteristics of women with PCOS, and determine the association between Antimullerian Hormone (AMH) and PCOS. Patients and Methods: In a clinical case series, 544 women with PCOS were included in this study. Body mass index (BMI), Homeostasis Model Assessment (HOMA), Quantitative Insulin Sensitivity Check Index (QUICKI), and Matsuda index were calculated. Sixty-three women with PCOS and 50 age- and BMI-matched control patients underwent blood sampling for AMH level. Results: The most common clinical presentation of PCOS in this study was menstrual irregularity followed by hirsutism and infertility. There was no statistically significant difference in the clinical presentation or hormonal profile in women with PCOS according to different BMI categories. The prevalence of insulin resistance among women with PCOS was 37.7%, 69.3%, and 75.8% using HOMA, QUICKI, and Matsuda index, respectively. Furthermore, the Matsuda index had the highest detection rate of insulin resistance, especially in underweight women with PCOS (94.1%). AMH levels in women with PCOS were significantly higher than that in the control group (P-value = 0.015). Conclusion: Insulin resistance is prevalent among women with PCOS. The detection rate of insulin resistance varies according to the insulin sensitivity index used. Menstrual irregularity was the most common presentation of PCOS. Women with PCOS have significantly higher levels of AMH levels compared to women in the control group.
    Type of Medium: Online Resource
    ISSN: 1573-3998
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2020
    Location Call Number Limitation Availability
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  • 4
    Online Resource
    Online Resource
    Bentham Science Publishers Ltd. ; 2020
    In:  Current Diabetes Reviews Vol. 16, No. 8 ( 2020-09-11), p. 910-915
    In: Current Diabetes Reviews, Bentham Science Publishers Ltd., Vol. 16, No. 8 ( 2020-09-11), p. 910-915
    Abstract: Diabetic foot is a major public health problem and their complications are an imperative cause of morbidity and mortality in diabetes. Objective: To evaluate the rate of recurrence of foot ulcers post two years of follow-up, including the associated risk factors in the patients attending the diabetic foot clinic at the National Center for Diabetes, Endocrinology, and Genetics (NCDEG), Amman, Jordan. Methods: A historical cohort design was adopted for the patients who presented for the first time to the diabetic foot clinic at the NCDEG. Every patient who came to the clinic was reviewed by using his or her medical files with respect to diabetic foot-related complaints. Patients were classified under four categories: (1) Recurrent foot ulcers (2) chronic foot ulcer (3) free of recurrence, and (4) no foot ulcers. Among the four groups, group 1 (recurrent foot ulcers, n=76) and group 3 (free of recurrence, n=54) were included for the analysis. Results: Among the 141 patients who presented to the diabetic foot clinic during the two-year study period, 76 (53.9%) of them experienced ulcer recurrences, 54 (38.3%) were recurrence-free, and 11 (7.8%) had chronic ulceration. The two-year recurrence rate was 58.5%. The presence of deformity and osteomyelitis were the statistically significant independent risk factors for recurrent foot ulceration. Conclusion: This study of recurrences was clearly related to the type and complications of the ulcers rather than to the other variables. Recurrent foot ulceration is linked to the presence of osteomyelitis and/or deformities.
    Type of Medium: Online Resource
    ISSN: 1573-3998
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2020
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  • 5
    Online Resource
    Online Resource
    Bentham Science Publishers Ltd. ; 2017
    In:  Current Diabetes Reviews Vol. 13, No. 2 ( 2017-02-17), p. 182-191
    In: Current Diabetes Reviews, Bentham Science Publishers Ltd., Vol. 13, No. 2 ( 2017-02-17), p. 182-191
    Type of Medium: Online Resource
    ISSN: 1573-3998
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2017
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