In:
Journal of Comparative Effectiveness Research, Becaris Publishing Limited, Vol. 8, No. 12 ( 2019-09), p. 1013-1025
Abstract:
Aim: The aim of this project is to describe a causal (counterfactual) approach for analyzing when to start statin treatment to prevent cardiovascular disease using real-world evidence. Methods: We use directed acyclic graphs to operationalize and visualize the causal research question considering selection bias, potential time-independent and time-dependent confounding. We provide a study protocol following the ‘target trial’ approach and describe the data structure needed for the causal assessment. Conclusion: The study protocol can be applied to real-world data, in general. However, the structure and quality of the database play an essential role for the validity of the results, and database-specific potential for bias needs to be explicitly considered.
Type of Medium:
Online Resource
ISSN:
2042-6305
,
2042-6313
DOI:
10.2217/cer-2018-0103
Language:
English
Publisher:
Becaris Publishing Limited
Publication Date:
2019
detail.hit.zdb_id:
2669725-7
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