Publication Date:
2014-03-20
Description:
Commentary on: Nielsen OH , Loftus EV, Jess T. Safety of TNF-α inhibitors during IBD pregnancy: a systematic review. BMC Med 2013 ; 11 : 174 . Context The diagnosis of inflammatory bowel disease (IBD) overlaps with the reproductive years in many patients’ lives. Therefore, there is an important need for valid data to support medical decision-making around conception planning and pregnancy in IBD. Given that tumour necrosis factor α (TNF-α) inhibitors are highly effective options for inducing and maintaining a clinical remission, their risks and benefits need to be well understood in the context of maternal and fetal outcomes. This systematic review addresses the risk of adverse birth outcomes due to maternal TNF-α inhibitor therapy. Methods This was a well-conducted review of all currently available studies of the risks of TNF-α therapy in pregnant patients. Study types included case–control studies, case series and case reports. Investigators assessed adverse birth outcomes...
Keywords:
Inflammatory bowel disease, Epidemiologic studies, Immunology (including allergy), Pregnancy, Ethics
Print ISSN:
1356-5524
Electronic ISSN:
1473-6810
Topics:
Medicine
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