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  • 1
    Online Resource
    Online Resource
    Diabetes among adults in Bangladesh: changes in prevalence and risk factors between two cross-sectional surveys
    BMJ ; 2022
    In:  BMJ Open Vol. 12, No. 8 ( 2022-08), p. e055044-
    Details
    In: BMJ Open, BMJ, Vol. 12, No. 8 ( 2022-08), p. e055044-
    Abstract: To investigate the change in the prevalence and risk factors of diabetes among adults in Bangladesh between 2011 and 2018. Design The study used two waves of nationally representative cross-sectional data extracted from the Bangladesh Demographic and Health Surveys in 2011 and 2017–2018. Setting Bangladesh. Participants 14 376 adults aged ≥35 years. Primary outcome Diabetes mellitus (type 2 diabetes). Results From 2011 to 2018, the diabetes prevalence among adults aged ≥35 years increased from 10.95% (880) to 13.75% (922) (p 〈 0.001), with the largest-relative increase (90%) among obese individuals. Multivariable logistic regression analysis identified age and body mass index (BMI) were the key risk factors for diabetes. Adults who were overweight or obese were 1.54 times (adjusted OR (AOR): 1.54, 95% CI: 1.20 to 1.97) more likely to develop diabetes than normal-weight individuals in 2011, and 1.22 times (AOR: 1.22, 95% CI: 1.00 to 1.50) and 1.44 times (AOR: 1.44, 95% CI: 1.13 to 1.84) more prone to develop diabetes in 2018. Other significant risk factors for diabetes were marital status, education, geographical region, wealth index and hypertension status in both survey years. Conclusion A high prevalence of diabetes was observed and it has been steadily increasing over time. To enhance diabetes detection and prevention among adults in Bangladesh, population-level interventions focusing on health education, including a healthy diet and lifestyle, are required.
    Type of Medium: Online Resource
    ISSN: 2044-6055 , 2044-6055
    URL: Article
    URL: Article
    DOI: 10.1136/bmjopen-2021-055044
    DOI: 10.1136/bmjopen-2021-055044.supp1
    Language: English
    Publisher: BMJ
    Publication Date: 2022
    detail.hit.zdb_id: 2599832-8
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  • 2
    Online Resource
    Online Resource
    Trends, prevalence and risk factors of overweight and obesity among women of reproductive age in Bangladesh: a pooled analysis of five national cross-sectional surveys
    BMJ ; 2018
    In:  BMJ Open Vol. 8, No. 7 ( 2018-07), p. e018468-
    Details
    In: BMJ Open, BMJ, Vol. 8, No. 7 ( 2018-07), p. e018468-
    Abstract: To determine the trends, prevalence and risk factors of overweight and obesity among Bangladeshi women of reproductive age from 1999 to 2014. Design We analysed nationally representative data from the 1999, 2004, 2007, 2011 and 2014 cross-sectional Bangladesh Demographic and Health Surveys. Setting Bangladesh. Participants Women aged 15–49 years. Primary outcome Overweight/obesity. Results A total of 58 192 women were included in the analysis. The prevalence of overweight and obesity among women of reproductive age increased significantly from 7.53% (95% CI 6.83 to 8.29) and 1.82% (95% CI 1.48 to 2.24) in 1999 to 28.37% (95% CI 27.49 to 29.28) and 10.77% (95% CI 10.22 to 11.35) in 2014, respectively. Age, education, wealth index, watching television and contraceptive use were associated with overweight and obesity in both urban and rural areas. Conclusions Overweight and obesity prevalence increased significantly among Bangladeshi women of reproductive age between 1999 and 2014. Development of effective low-cost strategies to address the increasing burden of obesity should be a high priority.
    Type of Medium: Online Resource
    ISSN: 2044-6055 , 2044-6055
    URL: Article
    URL: Article
    DOI: 10.1136/bmjopen-2017-018468
    DOI: 10.1136/bmjopen-2017-018468.supp1
    Language: English
    Publisher: BMJ
    Publication Date: 2018
    detail.hit.zdb_id: 2599832-8
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  • 3
    Online Resource
    Online Resource
    Review of novel therapeutics in cardiac arrest (ReNTICA): systematic review protocol
    BMJ ; 2022
    In:  BMJ Open Vol. 12, No. 1 ( 2022-01), p. e053304-
    Details
    In: BMJ Open, BMJ, Vol. 12, No. 1 ( 2022-01), p. e053304-
    Abstract: Cardiac arrest remains a common and devastating cause of death and disability worldwide. While targeted temperature management has become standard of care to improve functional neurologic outcome, few pharmacologic interventions have shown similar promise. Methods/analysis This systematic review will focus on prospective human studies from 2015 to 2020 available in PubMed, Web of Science and EMBASE with a primary focus on impact on functional neurologic outcome. Prospective studies that include pharmacologic agents given during or after cardiac arrest will be included. Study selection will be in keeping with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. If sufficient data involving a given agent are available, a meta-analysis will be conducted and compared with current evidence for therapies recommended in international practice guidelines. Ethics and dissemination Formal ethical approval will not be required as primary data will not be collected. The results will be disseminated through peer-reviewed publication, conference presentation and lay press. PROSPERO registration number International Prospective Register for Systematic Reviews (CRD42021230216).
    Type of Medium: Online Resource
    ISSN: 2044-6055 , 2044-6055
    URL: Article
    DOI: 10.1136/bmjopen-2021-053304
    Language: English
    Publisher: BMJ
    Publication Date: 2022
    detail.hit.zdb_id: 2599832-8
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  • 4
    Online Resource
    Online Resource
    Combination release of chemokines from coated coils to target aneurysm healing
    BMJ ; 2023
    In:  Journal of NeuroInterventional Surgery Vol. 15, No. 7 ( 2023-07), p. 689-694
    Details
    In: Journal of NeuroInterventional Surgery, BMJ, Vol. 15, No. 7 ( 2023-07), p. 689-694
    Abstract: Monocyte chemoattractant protein 1 (MCP-1) and osteopontin (OPN) have been identified separately as key mediators of the aneurysm healing process following coil embolization in the rodent model. The ability of protein coated coils to accelerate this process is currently unknown. Objective To create coils coated with both MCP-1 and OPN to target aneurysm healing. Methods We used a polymer (poly(glycolide-co-caprolactone)) (Rao pharmaceuticals) (CG910) to test whether coils could be dual coated with active proteins with sequential reliable release. Coils were coated with poly-DL-lactic glycolic acid (PLGA), CG910, and subsequently dipped with protein OPN (inner layer for delayed release) and MCP-1 (outer layer for initial release). Release assays were used to measure protein elution from coils over time. To test in vivo feasibility, coated coils were implanted into carotid aneurysms to determine the effect on aneurysm healing. Results The in vitro protein release assay demonstrated a significant amount of OPN and MCP-1 release within 2 days. Using a 200 µg/µL solution of MCP-1 in phosphate-buffered saline, we showed that CG910 coated coils provide effective release of MCP over time. In the carotid aneurysm model, MCP-1 and OPN coated coils significantly increased tissue ingrowth (74% and 80%) compared with PLGA and CG910 coated coils alone (58% and 53%). To determine synergistic impact of dual coating, we measured ingrowth for MCP-1/OPN coils (63%) as well as overlap coefficients for NOX4 and NFκB with CD31. Conclusions This study demonstrates that MCP-1 and OPN coated coils are viable and may promote early aneurysm healing. Dual coated coils may have synergistic benefit given different location of protein interaction measured in vivo. Further work is warranted.
    Type of Medium: Online Resource
    ISSN: 1759-8478 , 1759-8486
    URL: Article
    DOI: 10.1136/neurintsurg-2022-018710
    Language: English
    Publisher: BMJ
    Publication Date: 2023
    detail.hit.zdb_id: 2506028-4
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