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  • 1
    Publication Date: 2016-01-28
    Description: We report the discovery of ASASSN-15lh (SN 2015L), which we interpret as the most luminous supernova yet found. At redshift z = 0.2326, ASASSN-15lh reached an absolute magnitude of Mu ,AB = -23.5 +/- 0.1 and bolometric luminosity Lbol = (2.2 +/- 0.2) x 10(45) ergs s(-1), which is more than twice as luminous as any previously known supernova. It has several major features characteristic of the hydrogen-poor super-luminous supernovae (SLSNe-I), whose energy sources and progenitors are currently poorly understood. In contrast to most previously known SLSNe-I that reside in star-forming dwarf galaxies, ASASSN-15lh appears to be hosted by a luminous galaxy (MK approximately -25.5) with little star formation. In the 4 months since first detection, ASASSN-15lh radiated (1.1 +/- 0.2) x 10(52) ergs, challenging the magnetar model for its engine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dong, Subo -- Shappee, B J -- Prieto, J L -- Jha, S W -- Stanek, K Z -- Holoien, T W-S -- Kochanek, C S -- Thompson, T A -- Morrell, N -- Thompson, I B -- Basu, U -- Beacom, J F -- Bersier, D -- Brimacombe, J -- Brown, J S -- Bufano, F -- Chen, Ping -- Conseil, E -- Danilet, A B -- Falco, E -- Grupe, D -- Kiyota, S -- Masi, G -- Nicholls, B -- Olivares E, F -- Pignata, G -- Pojmanski, G -- Simonian, G V -- Szczygiel, D M -- Wozniak, P R -- New York, N.Y. -- Science. 2016 Jan 15;351(6270):257-60. doi: 10.1126/science.aac9613.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Kavli Institute for Astronomy and Astrophysics, Peking University, Yi He Yuan Road 5, Hai Dian District, Beijing 100871, China. dongsubo@pku.edu.cn. ; Carnegie Observatories, 813 Santa Barbara Street, Pasadena, CA 91101, USA. ; Nucleo de Astronomia de la Facultad de Ingenieria, Universidad Diego Portales, Av. Ejercito 441, Santiago, Chile. Millennium Institute of Astrophysics, Santiago, Chile. ; Department of Physics and Astronomy, Rutgers, The State University of New Jersey, 136 Frelinghuysen Road, Piscataway, NJ 08854, USA. ; Department of Astronomy, The Ohio State University, 140 W. 18th Avenue, Columbus, OH 43210, USA. Center for Cosmology and AstroParticle Physics (CCAPP), The Ohio State University, 191 W. Woodruff Avenue, Columbus, OH 43210, USA. ; Las Campanas Observatory, Carnegie Observatories, Casilla 601, La Serena, Chile. ; Department of Astronomy, The Ohio State University, 140 W. 18th Avenue, Columbus, OH 43210, USA. ; Department of Astronomy, The Ohio State University, 140 W. 18th Avenue, Columbus, OH 43210, USA. Center for Cosmology and AstroParticle Physics (CCAPP), The Ohio State University, 191 W. Woodruff Avenue, Columbus, OH 43210, USA. Department of Physics, The Ohio State University, 191 W. Woodruff Avenue, Columbus, OH 43210, USA. ; Astrophysics Research Institute, Liverpool John Moores University, 146 Brownlow Hill, Liverpool L3 5RF, UK. ; Coral Towers Observatory, Cairns, Queensland 4870, Australia. ; INAF-Osservatorio Astrofisico di Catania, Via S.Sofia 78, 95123, Catania, Italy. ; Department of Astronomy, Peking University, Yi He Yuan Road 5, Hai Dian District, 100871, P. R. China. ; Association Francaise des Observateurs d'Etoiles Variables (AFOEV), Observatoire de Strasbourg 11, rue de l'Universite, F-67000 Strasbourg, France. ; Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138, USA. ; Department of Earth and Space Science, Morehead State University, 235 Martindale Drive, Morehead, KY 40351, USA. ; Variable Star Observers League in Japan (VSOLJ), 7-1 Kitahatsutomi, Kamagaya, Chiba 273-0126, Japan. ; The Virtual Telescope Project, Via Madonna de Loco 47, 03023 Ceccano, Italy. ; Mt Vernon Observatory, 6 Mt Vernon pl, Nelson, New Zealand. ; Millennium Institute of Astrophysics, Santiago, Chile. Departamento Ciencias Fisicas, Universidad Andres Bello, Av. Republica 252, Santiago, Chile. ; Warsaw University Astronomical Observatory, Al. Ujazdowskie 4, 00-478 Warsaw, Poland. ; Los Alamos National Laboratory, Mail Stop B244, Los Alamos, NM 87545, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26816375" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 2016-04-28
    Description: Large rivers create major gaps in reef distribution along tropical shelves. The Amazon River represents 20% of the global riverine discharge to the ocean, generating up to a 1.3 x 10 6 –km 2 plume, and extensive muddy bottoms in the equatorial margin of South America. As a result, a wide area of the tropical North Atlantic is heavily affected in terms of salinity, pH, light penetration, and sedimentation. Such unfavorable conditions were thought to imprint a major gap in Western Atlantic reefs. We present an extensive carbonate system off the Amazon mouth, underneath the river plume. Significant carbonate sedimentation occurred during lowstand sea level, and still occurs in the outer shelf, resulting in complex hard-bottom topography. A permanent near-bottom wedge of ocean water, together with the seasonal nature of the plume’s eastward retroflection, conditions the existence of this extensive (~9500 km 2 ) hard-bottom mosaic. The Amazon reefs transition from accretive to erosional structures and encompass extensive rhodolith beds. Carbonate structures function as a connectivity corridor for wide depth–ranging reef-associated species, being heavily colonized by large sponges and other structure-forming filter feeders that dwell under low light and high levels of particulates. The oxycline between the plume and subplume is associated with chemoautotrophic and anaerobic microbial metabolisms. The system described here provides several insights about the responses of tropical reefs to suboptimal and marginal reef-building conditions, which are accelerating worldwide due to global changes.
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
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  • 3
    Publication Date: 2013-04-06
    Description: Ice cores from low latitudes can provide a wealth of unique information about past climate in the tropics, but they are difficult to recover and few exist. Here, we report annually resolved ice core records from the Quelccaya ice cap (5670 meters above sea level) in Peru that extend back ~1800 years and provide a high-resolution record of climate variability there. Oxygen isotopic ratios (delta(18)O) are linked to sea surface temperatures in the tropical eastern Pacific, whereas concentrations of ammonium and nitrate document the dominant role played by the migration of the Intertropical Convergence Zone in the region of the tropical Andes. Quelccaya continues to retreat and thin. Radiocarbon dates on wetland plants exposed along its retreating margins indicate that it has not been smaller for at least six millennia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thompson, L G -- Mosley-Thompson, E -- Davis, M E -- Zagorodnov, V S -- Howat, I M -- Mikhalenko, V N -- Lin, P-N -- New York, N.Y. -- Science. 2013 May 24;340(6135):945-50. doi: 10.1126/science.1234210. Epub 2013 Apr 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Byrd Polar Research Center, The Ohio State University, Columbus, OH 43210, USA. thompson.3@osu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23558172" target="_blank"〉PubMed〈/a〉
    Keywords: *Climate Change ; *Ice Cover ; Nitrates/analysis ; Oxygen Isotopes/analysis ; Peru ; Plants ; Quaternary Ammonium Compounds/analysis ; *Tropical Climate ; Wetlands
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    American Association for the Advancement of Science (AAAS)
    In:  Science, 346 (6214). pp. 1227-1231.
    Publication Date: 2016-09-09
    Description: Decadal trends in the properties of seawater adjacent to Antarctica are poorly known, and the mechanisms responsible for such changes are uncertain. Antarctic ice sheet mass loss is largely driven by ice shelf basal melt, which is influenced by ocean-ice interactions and has been correlated with Antarctic Continental Shelf Bottom Water (ASBW) temperature. We document the spatial distribution of long-term large-scale trends in temperature, salinity, and core depth over the Antarctic continental shelf and slope. Warming at the seabed in the Bellingshausen and Amundsen seas is linked to increased heat content and to a shoaling of the mid-depth temperature maximum over the continental slope, allowing warmer, saltier water greater access to the shelf in recent years. Regions of ASBW warming are those exhibiting increased ice shelf melt.
    Type: Article , PeerReviewed
    Format: text
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  • 5
    Publication Date: 2015-10-25
    Description: In nature, plants and their pollinating and/or seed-dispersing animals form complex interaction networks. The commonly observed pattern of links between specialists and generalists in these networks has been predicted to promote species coexistence. Plants also build highly species-rich mutualistic networks below ground with root-associated fungi, and the structure of these plant–fungus networks may also affect terrestrial community processes. By compiling high-throughput DNA sequencing data sets of the symbiosis of plants and their root-associated fungi from three localities along a latitudinal gradient, we uncovered the entire network architecture of these interactions under contrasting environmental conditions. Each network included more than 30 plant species and hundreds of mycorrhizal and endophytic fungi belonging to diverse phylogenetic groups. The results were consistent with the notion that processes shaping host-plant specialization of fungal species generate a unique linkage pattern that strongly contrasts with the pattern of above-ground plant–partner networks. Specifically, plant–fungus networks lacked a "nested" architecture, which has been considered to promote species coexistence in plant–partner networks. Rather, the below-ground networks had a conspicuous "antinested" topology. Our findings lead to the working hypothesis that terrestrial plant community dynamics are likely determined by the balance between above-ground and below-ground webs of interspecific interactions.
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
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  • 6
    Publication Date: 2016-06-05
    Description: Local prefrontal dopamine signaling supports working memory by tuning pyramidal neurons to task-relevant stimuli. Enabled by simultaneous positron emission tomography–magnetic resonance imaging (PET-MRI), we determined whether neuromodulatory effects of dopamine scale to the level of cortical networks and coordinate their interplay during working memory. Among network territories, mean cortical D 1 receptor densities differed substantially but were strongly interrelated, suggesting cross-network regulation. Indeed, mean cortical D 1 density predicted working memory–emergent decoupling of the frontoparietal and default networks, which respectively manage task-related and internal stimuli. In contrast, striatal D 1 predicted opposing effects within these two networks but no between-network effects. These findings specifically link cortical dopamine signaling to network crosstalk that redirects cognitive resources to working memory, echoing neuromodulatory effects of D 1 signaling on the level of cortical microcircuits.
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
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  • 7
    Publication Date: 2016-02-14
    Description: Peptidyl arginine deiminase 4 (PAD4) is a nuclear enzyme that converts arginine residues to citrulline. Although increasingly implicated in inflammatory disease and cancer, the mechanism of action of PAD4 and its functionally relevant pathways remains unclear. E2F transcription factors are a family of master regulators that coordinate gene expression during cellular proliferation and diverse cell fates. We show that E2F-1 is citrullinated by PAD4 in inflammatory cells. Citrullination of E2F-1 assists its chromatin association, specifically to cytokine genes in granulocyte cells. Mechanistically, citrullination augments binding of the BET (bromodomain and extra-terminal domain) family bromodomain reader BRD4 (bromodomain-containing protein 4) to an acetylated domain in E2F-1, and PAD4 and BRD4 coexist with E2F-1 on cytokine gene promoters. Accordingly, the combined inhibition of PAD4 and BRD4 disrupts the chromatin-bound complex and suppresses cytokine gene expression. In the murine collagen-induced arthritis model, chromatin-bound E2F-1 in inflammatory cells and consequent cytokine expression are diminished upon small-molecule inhibition of PAD4 and BRD4, and the combined treatment is clinically efficacious in preventing disease progression. Our results shed light on a new transcription-based mechanism that mediates the inflammatory effect of PAD4 and establish the interplay between citrullination and acetylation in the control of E2F-1 as a regulatory interface for driving inflammatory gene expression.
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
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  • 8
    Publication Date: 2018-04-20
    Description: The ability to control multidimensional quantum systems is central to the development of advanced quantum technologies. We demonstrate a multidimensional integrated quantum photonic platform able to generate, control, and analyze high-dimensional entanglement. A programmable bipartite entangled system is realized with dimensions up to 15 x 15 on a large-scale silicon photonics quantum circuit. The device integrates more than 550 photonic components on a single chip, including 16 identical photon-pair sources. We verify the high precision, generality, and controllability of our multidimensional technology, and further exploit these abilities to demonstrate previously unexplored quantum applications, such as quantum randomness expansion and self-testing on multidimensional states. Our work provides an experimental platform for the development of multidimensional quantum technologies.
    Keywords: Physics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
    Publication Date: 2017-07-21
    Description: Baranovskiy et al . and Pellegrini argue that, based on structural data, the path for charge transfer through the [4Fe4S] domain of primase is not feasible. Our manuscript presents electrochemical data directly showing charge transport through DNA to the [4Fe4S] cluster of a primase p58C construct and a reversible switch in the DNA-bound signal with oxidation/reduction, which is inhibited by mutation of three tyrosine residues. Although the dispositions of tyrosines differ in different constructs, all are within range for microsecond electron transfer.
    Keywords: Biochemistry, Online Only
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
    Publication Date: 2017-07-22
    Description: The human genetic material is packaged into 46 chromosomes. The structure of chromosomes is known at the lowest level, where the DNA chain is wrapped around a core of eight histone proteins to form nucleosomes. Around a million of these nucleosomes, each about 11 nm in diameter and 6 nm in thickness, are wrapped up into the complex organelle of the chromosome, whose structure is mostly known at the level of visible light microscopy to form a characteristic cross shape in metaphase. However, the higher-order structure of human chromosomes, between a few tens and hundreds of nanometers, has not been well understood. We show a three-dimensional (3D) image of a human prophase nucleus obtained by serial block-face scanning electron microscopy, with 36 of the complete set of 46 chromosomes captured within it. The acquired image allows us to extract quantitative 3D structural information about the nucleus and the preserved, intact individual chromosomes within it, including their positioning and full spatial morphology at a resolution of around 50 nm in three dimensions. The chromosome positions were found, at least partially, to follow the pattern of chromosome territories previously observed only in interphase. The 3D conformation shows parallel, planar alignment of the chromatids, whose occupied volumes are almost fully accounted for by the DNA and known chromosomal proteins. We also propose a potential new method of identifying human chromosomes in three dimensions, on the basis of the measurements of their 3D morphology.
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
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