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  • 1
    Electronic Resource
    Electronic Resource
    Copenhagen : Munksgaard International Publishers
    Experimental dermatology 10 (2001), S. 0 
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Dendritic cells seem to be of major importance for the pathogenesis of psoriasis. They are increased in number in lesional psoriatic skin which is thought to be due to an increased influx from the peripheral blood regulated by chemotaxins. Using a biological/biochemical approach we have addressed the question whether psoriasis scale extracts contain proteinaceous chemotaxins for dendritic cells. Human monocytes differentiated into dendritic cells by culture with GM-CSF and IL-4 (MoDC) served as responder cells. Chemotactic activity for MoDC was purified by several HPLC-steps. The results of our study show that C5a/C5adesarg is the major chemotactic peptide for MoDC in psoriasis scale extracts. In comparison to other stimuli such as fMLP or monocyte chemotactic peptide 1 (MCP-1) C5a proved to be a most potent and efficient chemotaxin for MoDC. C5a co-eluted with MRP14/calgranulin B which is present in large amounts in psoriasis scale extracts as identified by amino acid sequencing. However, MRP14/calgranulin B did not possess any chemotactic activity for MoDC. Our results provide evidence that C5a/C5adesarg although not specific for dendritic cells seems to be the major chemoattractant for these cells in lesional psoriasis skin.
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  • 2
    Electronic Resource
    Electronic Resource
    Copenhagen : Munksgaard International Publishers
    Experimental dermatology 9 (2000), S. 0 
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The etiology and pathogenesis of psoriasis – one of the most common chronic, inflammatory, hyperproliferative skin disorders of man – have long fascinated dermatologists, pathologists and biologists alike. Here, we have a model disease that offers to study neuroectodermal-mesenchymal interactions in the widest sense possible. Epithelial, endothelial, and hematopoietic cells as well as neurons projecting into the skin apparently all interact with each other to generate the characteristic psoriatic lesion. For decades, the ongoing controversy on the molecular nature, choreography and hierarchy of these complex interactions e.g. between epidermal keratinocytes, T cells, neurotrophils, endothelial cells and sensory nerves has served as a driving force propelling investigative dermatology to ever new horizons. This debate has not only been at the heart of our quest to develop more effective forms of therapy for this socially crippling disease, but it also has profoundly influenced how we view the skin as a whole: the numerous competing theories on the pathogenesis of psoriasis published so far also are reflections on the evolution of mainstream thought in skin biology over the last decades. These days, conventional wisdom – infatuated with a T-cell-centered approach to inflammatory skin diseases – portrays psoriasis as an autoimmune disease, where misguided T lymphocyte activities cause secondary epithelial abnormalities. And yet, as this CONTROVERSIES feature reminds us, some authoritative “pockets of academic resistance” are still quite alive, and interpret psoriasis e.g. as a genetically determined, abnormal epithelial response pattern to infectious and/or physicochemical skin insults. Weighing the corresponding lines of argumentation is not only an intriguing, clinically relevant intellectual exercise, but also serves as a wonderful instrument for questioning our own views of the skin universe and its patterns of deviation from a state of homeostasis.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Munksgaard International Publishers
    Allergy 57 (2002), S. 0 
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: To gain insight into the mechanisms responsible for tissue neutrophil immigration in sinusitis, primary nasal fibroblasts are analyzed for synthesizing and delivering neutrophil chemokines.Methods: Primary nasal fibroblast cell culture was treated with tumor necrosis factor (TNF)-α concentrations of 20 and 200 ng/ml for 2, 8, 24 and 72 h. Chemokine concentrations in supernatants were determined by enzyme-linked immunoassay (ELISA) and chemokine mRNA expression in fibroblasts was measured by reverse transcriptase polymerase chain reaction (RT-PCR). Biological chemotactic activity was identified by three-step high-performance liquid chromatography (HPLC) and by bioassay measuring neutrophil chemotaxis in a single Boyden chamber system.Results: Interleukin (IL)-8 and growth-related oncogene (GRO)-α were induced in nasal fibroblast culture by proinflammatory stimulus. After 24 h of stimulation neutrophil chemotactic activity only was detected for IL-8. Granulocyte chemotactic protein (GCP)-2 mRNA was already significantly up-regulated after 2 h of stimulation.Conclusion: Induction of IL-8 protein dominates chemokine synthesis 24 and 72 h after stimulation, whereas induction of GCP-2 mRNA seems to have a role in the early phase after 2 h of exposition with TNF-α.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European journal of wildlife research 13 (1967), S. 63-75 
    ISSN: 1439-0574
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Description / Table of Contents: Summary Roe deer had browsed the 7–8 year old spruce trees — in some cases rather severely — on two experimentally controlled fertilizer plots. This provided the opportunity to registrate the damages exactly and to separate them, partially according to plots and partially according to the individual plants and their growth characteristics. The distribution of the damages over the two parcels was determined essentially by the local environmental climate, available protective cover and soil vegetation but, on the other hand, only insignificantly by the combination of fertilizers applied. The differentiation according to individual plants revealed that the latebudding spruce trees as well as those with widely spaced, long, thin and “blue” needles had been most severely browsed. There are certain correlations between these characteristics and it is as yet unclear which of them is decisive in determining the deers' preference for the buds. On the other hand, a tendency toward the formation of buds of the nature mentioned exists on plots containing nitrogen, especially on those containing nitrogen-potassium and nitrogen-phosphorous compounds.
    Abstract: Résumé Sur deux plantations expérimentales amendées, le chevreuil (Capreolus capreolus) a abrouti, localement assez fort, des épicéas de 7–8 ans. L'occasion se présentait d'enregistrer les dégâts de façon précise, soit selon les parcelles soit selon les plants individuels et d'en relever les caractères de croissance. Si la répartition des dégâts selon les parcelles fut essentiellement fonction du microclimat, des ressources en fourrés et de la strate herbacée, les formules de fumure furent par contre sans effet notoire. L'observation des plants individuels révéla que les pousses tardives de même que les plants présentant des aiguilles distantes, longues fines et glauques étaient les plus abroutis. Certaines corrélations existent entre ces différents caractères et on ne peut encore distinguer avec évidence quel est celui qui détermine une appétence préférentielle. A leur tour, ce sont les parcelles azotées, et surtout celles ayant reçu une fumure NK et NP qui présentent une tendance à la formation de pousses aux propriétés mentionnées plus haut.
    Notes: Zusammenfassung Auf zwei Düngungs-Versuchsflächen hatte Rehwild die dort stehenden 7-bis 8 jährigen Fichten z. T. ziemlich stark verbissen. Es both sich Gelegenheit, die Schäden genau zu registrieren und teils nach Parzellen, teils nach Einzelpflanzen und deren Wuchsmerkmalen aufzuschlüsseln. Die Verteilung der Schäden über die Parzellen wurde wesenlich dagegen durch die Düngungskombinationen bestimmt. Die Aufschlüsselung nach Einzelpflanzen ergab, daß Spättreiber sowie Fichten mit weitständigen, langen, dünnen und „blauen” Nadeln am stärksten verbissen worden waren. Zwischen diesen Merkmalen bestehen gewisse Korrelationen, und es ist noch undurchsichtig, welche von ihnen die Präferenzen bestimmen. Eine Tendenz zur Ausbildung von Trieben der genannten Beschaffenheit besteht wiederum auf den N-haltigen Parzellen, vor allem auf NK und NP.
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    International journal of legal medicine 55 (1964), S. 246-246 
    ISSN: 1437-1596
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    International journal of legal medicine 59 (1967), S. 65-69 
    ISSN: 1437-1596
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Neurosurgical review 22 (1999), S. 62-64 
    ISSN: 1437-2320
    Keywords: Key words Cervical spine injuries ; Mayfield head rest ; Halo ring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A small device is described helping to attach a Mayfield head rest to a patient who is already in a Halo device for a cervical spine injury. This makes it very easy to position the patient prior to anesthesia for performing cervical spine surgery.
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  • 8
    ISSN: 1434-3932
    Keywords: Schlüsselwörter  Apoplexie ; Karotis-TEA ; Karotisstenting ; Neuromonitoring ; Embolie ; Transkranielle Dopplersonographie ; Key words Stroke ; Carotid TEA ; Carotid stenting ; Neuromonitoring ; Emboli
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract  In a retrospective study we examined whether it is possible to achieve better results in carotid artery surgery with a new operative technique called ”no-touch-isolation technique” in combination with intraoperative angiography than with conventional operative techniques. Patients and methods: In 1997 and 1998, 80 patients who were operated on using this new operative technique were compared with a group of 144 patients who had undergone conventional carotid endarterectomy. The new aspect of the no-touch-isolation technique is that the whole operation strategy aims to avoid possible intraoperative and postoperative embolism. At first, the internal carotid artery is exposed and clamped distally to the stenotic plaque very atraumatically. The operation was then continued without an intraluminal shunt. At the end of the operation the result was checked by means of an intraoperative angiography. If any suggestion of a possible embolism, such as tears of the intima, were seen, an intraoperative revision was carried out until all thrombembolic material was removed. Results: The two groups were not different regarding age, sex, symptoms, degree of stenosis and risk factors nor did any significant differences exist in the operative technique used for endarterectomy (with or without patch, eversions-TEA, etc.). The group operated on with the no-touch-isolation technique had significantly longer operation- times (110 min vs 90 min) and also significantly longer clamping times (38.7 min vs 28.2 min) than the group operated on using conventional technique. The postoperative results, however, were still better. There were significantly fewer neurological deficits (4.1% vs 9.3%). Conclusion: The no-touch-isolation technique in combination with intraoperative angiography is a very safe method of treatment in patients with symptomatic stenosis of the internal carotid artery with a more than 70% degree of stenosis.
    Notes: Zusammenfassung  In einer retro-spektiven Studie wurde untersucht, inwieweit sich mit einer Optimierung der Operationstechnik an der A. carotis, der sog. No-touch-isolation-Technik, bessere Ergebnisse erzielen lassen. 80 Patienten, die 1997 und 1998 in der neuen Technik operiert worden waren, wurden mit einer Gruppe von 144 Patienten, die zuvor in herkömmlicher Technik operiert worden waren, verglichen. Das Neue der No-touch-isolation-Technik bestand darin, dass die ganze Operationstaktik darauf abzielte, mögliche intraoperative und postoperative Embolien zu vermeiden. Zu diesem Zweck wurde als Erstes die A. carotis interna ganz atraumatisch freigelegt und distal des stenosierenden Plaques abge-klemmt. Anschließend erfolgte die weitere Operation ohne Einlage eines intraluminären Shunts. Am Ende der Operation wurde das Ope-rationsergebnis mittels einer intra-operativen Angiographie kontrol- liert. Wenn sich dabei mögliche übriggebliebene Embolisationsquellen, wie Intimalefzen zeigten, erfolgte eine intraoperative Revision, bis alle Embolisationsquellen besei-tigt waren. Die beiden verglichenen Gruppen unterschieden sich nicht bezüglich Alter, Geschlecht, Sympto-matik, Stenosegrad und Risikofaktoren. Auch bezüglich der angewandten Operationsverfahren (TEA mit oder ohne Patch, Eversions-TEA etc.) bestanden keine signifikanten Unterschiede. Die in No-touch-isolation-Technik operierte Gruppe hatte signifikant längere Operationszeiten (110 vs. 90 min) und auch signifikant längere Abklemmzeiten (38,7 vs. 28,2 min) als die in der herkömmlichen Technik operierte Gruppe. Die perioperativen Ergeb-nisse waren jedoch besser. So traten signifikant weniger neurologische Defizite auf (4,1 vs. 9,3%). Die No-touch-isolation-Technik in Verbindung mit einer intraoperativen Angiographie ist eine Methode mit einer sehr geringen Insultrate bei Patienten mit symptomatischen 〉70%igen Karotisstenosen.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 24 (1968), S. 91-91 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Cells ofRhodospirillum rubrum were cultured aerobically or semiaerobically in the dark and anaerobically in the light. The investigation of acid extracts of these cells showed, that this bacterium contained no ascorbic acid under all conditions of cultivation.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    European food research and technology 130 (1966), S. 145-152 
    ISSN: 1438-2385
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Zusammenfassung An Fleischproben des M. longissimus dorsi von 110 kg schweren Schweinen wurden spektralphotometrisch die Remissionswerte im Bereich von 380 nm bis 1500 nm gemessen und einige ausgewählte Fleischbeschaffenheitsmerkmale (pH-Wert, Quellung, Preßwasser, Kochverlust und Konsistenz) ermittelt sowie zwischen diesen Größen die Korrelationen berechnet. Im Rotbereich (〉 630 nm) ergaben sich die höchsten Korrelationskoeffizienten zwischen den Fleischremissionswerten und den analysierten Merkmalen (Quellung :r = -0,80; p11-Wert:r = −0,80; Preßwasserr = 0,69; Kochverlust:r = 0,68; Konsistenz:r = 0,51). Jedoch waren die Unterschiede gegenüber den bei 522 nm für den Hellbezugswert ermittelten Korrelationskoeffizienten nicht besonders groß, so daß im statistisch korrelativen Bild auch der HellbezugswertA =Y zur Charakterisierung der Fleischbeschaffenheitsmerkmale genügte. Die Übertragung der spektralphotometrisch erzielten Ergebnisse auf Messungen mit einem ortsunabhängigen Farbhellwertphotometer wurde am Beispiel des „Fahellpho Mariensee” demonstriert. Der Einsatz derartiger Meßgeräte zur objektivierten Schätzung von Fleischbeschaffenheitsmerkmalen, insbesondere zur schnellen Ansammlung von Daten für das Studium von Häufigkeitsverteilungen, wurde aufgezeigt.
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