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A comparative study of mixed least-squares FEMs for the incompressible Navier-Stokes equations (2013)

Schwarz, A. [VerfasserIn]

[Dortmund] : [Technische Universität, Fakultät für Mathematik]

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Keywords: Finite-Elemente-Methode ; Methode der kleinsten Quadrate ; Navier-Stokes-Gleichung

Type of Medium: Online Resource

Pages: 1 Online-Ressource (15 Seiten, 195,47 KB) , Diagramme

Series Statement: [Ergebnisberichte angewandte Mathematik] [No. 478]

URL: https://edocs.tib.eu/files/e01fn17/89506541X.pdf

DDC: 510

RVK:

SI 711

Language: English

Note: Reihentitel und -zählung der Druckausgabe entnommen , Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden

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Vaccine Protection against Bacillus cereus-Mediated Respiratory Anthrax-Like Disease in Mice [Microbial Immunity and Vaccines] (2013)

Oh, S.-Y., Maier, H., Schroeder, J., Richter, G. S., Elli, D., Musser, J. M., Quenee, L. E., Missiakas, D. M., Schneewind, O.

The American Society for Microbiology (ASM)

In: Infection and Immunity

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Publication Date: 2013-02-21

Description: Bacillus cereus strains harboring a pXO1-like virulence plasmid cause respiratory anthrax-like disease in humans, particularly in welders. We developed mouse models for intraperitoneal as well as aerosol challenge with spores of B. cereus G9241, harboring pBCXO1 and pBC218 virulence plasmids. Compared to wild-type B. cereus G9241, spores with a deletion of the pBCXO1-carried protective antigen gene ( pagA1 ) were severely attenuated, whereas spores with a deletion of the pBC218-carried protective antigen homologue ( pagA2 ) were not. Anthrax vaccine adsorbed (AVA) immunization raised antibodies that bound and neutralized the pagA1 -encoded protective antigen (PA1) but not the PA2 orthologue encoded by pagA2 . AVA immunization protected mice against a lethal challenge with spores from B. cereus G9241 or B. cereus Elc4, a strain that had been isolated from a fatal case of anthrax-like disease. As the pathogenesis of B. cereus anthrax-like disease in mice is dependent on pagA1 and PA-neutralizing antibodies provide protection, AVA immunization may also protect humans from respiratory anthrax-like death.

Print ISSN: 0019-9567

Electronic ISSN: 1098-5522

Topics: Medicine

Published by The American Society for Microbiology (ASM)

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