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  • 1
    Digitale Medien
    Digitale Medien
    THE ISOLATION OF CHOLINERGIC SYNAPTIC VESICLES FROM BOVINE SUPERIOR CERVICAL GANGLION AND ESTIMATION OF THEIR ACETYLCHOLINE CONTENT (1973)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 20 (1973), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract— A method is described for the isolation of relatively pure cholinergic synaptic vesicles by hypo-osmotic shock and density gradient centrifugation of a synaptosome fraction prepared from bovine superior cervical ganglia. Vesicles from this source were found to sediment to a density equivalent to 0·3–0·41 M-sucrose. The vesicle subfraction from the gradient had an acetylcholine (ACh) content of 4.4 nmol/mg of protein and were subject to leakage of ACh. By a ‘tagging’ technique, the vesicles were counted under the electron microscope and their numbers related to their ACh concentration. After correction for leakage, an ACh content of 1630 molecules/vesicle was estimated.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1973.tb00026.x
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  • 2
    Digitale Medien
    Digitale Medien
    Ultrastructural Evidence of Secretion by Exocytosis and of “Synaptic Vesicle” Formation in Posterior Pituitary Glands (1970)
    [s.l.] : Nature Publishing Group
    Nature 227 (1970), S. 407-409 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] We present here electron microscopic evidence, from posterior pituitary glands of rats and hamsters, leading to a quite different view, namely that the neurosecretory granules void their contents directly to the cell exterior by the process of exocytosis, and that synaptic vesicles arise as ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/227407a0
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  • 3
    Digitale Medien
    Digitale Medien
    Morphine Tolerance and Supersensitivity to 5-Hydroxytryptamine in the Myenteric Plexus of the Guinea-pig (1973)
    [s.l.] : Nature Publishing Group
    Nature 244 (1973), S. 168-170 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] Fig. 1 Dose-response curves for 5-HT. Data are for control strips (*) and morphine-tolerant preparations the third day after pellet implantation (). 5-HT was added to the bath 10 s after turning off the electrical stimulation. The ordinates represent tension in % of the preceding electrically ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/244168a0
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  • 4
    Digitale Medien
    Digitale Medien
    Micropinocytotic Origin of Coated and Smooth Microvesicles (“Synaptic Vesicles”) in Neurosecretory Terminals of Posterior Pituitary Glands demonstrated by Incorporation of Horseradish Peroxidase (1971)
    [s.l.] : Nature Publishing Group
    Nature 232 (1971), S. 341-342 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] This view implies that microvesicles of both sorts have been open, at some time, to the extracellular environment, and it should be possible to test this by determining whether they engulf marker substances that do not traverse the intact cell membrane. One such substance, horseradish peroxidase, ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/232341a0
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  • 5
    Digitale Medien
    Digitale Medien
    Coated Microvesicles in Neurosecretory Terminals of Posterior Pituitary Glands shed their Coats to become Smooth “Synaptic” Vesicles (1971)
    [s.l.] : Nature Publishing Group
    Nature 232 (1971), S. 340-341 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] Neurohypophyses of unanaesthetized rats were exposed following decapitation2 and fixed, according to Karnovsky6, during electrical stimulation. This yielded many microvesicles with readily discernible coats, some complete but others apparently partial. Such microvesicles can be seen mingled with ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/232340a0
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  • 6
    Digitale Medien
    Digitale Medien
    Rat folic acid reductase activity during the perinatal period, in newborns, and after trimethoprim administration (1972)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 274 (1972), S. 229-237 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Rat Folic Acid Reductase ; Pregnancy ; Fetus ; Newborns ; Trimethoprim
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The folic acid reductase activity in various organs of adult rats was studied in comparison to pregnant females (20th day of gestation) and fetal rats. The enzyme activities in the tissues of pregnant rats were in general about 30% higher than in normal adults. Fetal rats also possess the ability to catalyze the reduction of dihydrofolic acid, but it is evident that the liver and kidney have a considerably reduced capacity to form tetrahydrofolate. The folic acid reductase activity in liver and kidney rises for 10 days after birth and then declines to normal enzyme levels by the 4th week of life. Further studies concerning the interaction between trimethoprim and folic acid reductase in adult rats demonstrate that an oral dose of 5 or 50 mg/kg results in about a 30% increase of folic acid reductase activity in liver and kidney. The experiments suggest that there is a stimulation of enzyme synthesis following trimethoprim administration; because, the trimethoprim induced increase of the reductase activity is blocked by the administration of either puromycin or actinomycin D.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00501932
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  • 7
    Digitale Medien
    Digitale Medien
    Distribution and elimination of trimethoprim in pregnant and newborn rats (1972)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 272 (1972), S. 369-377 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Trimethoprim ; Placental Transfer ; Distribution ; Elimination ; Rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary After a single i.v. administration of 50 mg/kg of Trimethoprim (TM) to rats in late pregnancy, a diffusion equilibrium of the folic acid inhibitor in the foetal organs is reached after 30–60 min. The TM levels in maternal as well as in foetal organs can have an inhibitory effect on folic acid reductase activity. The elimination of TM is lower in pregnant than in non-pregnant animals. The TM elimination of the foeti is dependent on the elimination capacity of the mother. Three-days-old rats eliminate TM some four times slower than mature animals owing to their reduced kidney development.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00501243
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  • 8
    Digitale Medien
    Digitale Medien
    Inhibition of rat folic acid reductase activity by trimethoprim during the later stages of gestation (1973)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 278 (1973), S. 227-230 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Trimethoprim ; Rat Folic Acid Reductase ; Pregnancy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The increased level of folic acid reductase activity in rats during the perinatal period is inhibited following the oral administration of 5 or 50 mg/kg Trimethoprim. When the enzyme activity was tested in vitro, the highest sensitivity to the antimetabolite was displayed by the liver reductase isolated from rats the 20th day of pregnancy, the lowest was observed in the foetal liver extract. It is proposed that the stimulated reductase activity during the pregnancy is caused by a newly synthesized, Trimethoprim-sensitive enzyme form. The results of the in vitro experiments could contribute to the suggested hypothesis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00500653
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  • 9
    Digitale Medien
    Digitale Medien
    Optische Messungen an Amylose-Farbstoff-Komplexen (1970)
    Springer
    Colloid & polymer science 239 (1970), S. 578-580 
    Details
    ISSN: 1435-1536
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Maschinenbau
    Beschreibung / Inhaltsverzeichnis: Summary Upon addition of Congo red, neutral aqueous solutions of amylose show several induced Cotton-effects in the regio of the dye absorption bands. It is assumed that Congo red forms sterically ordered adducts with helical amylose segments. With several other azo dyes (methyl orange, α-naphthol orange, chrysophenin G), no induced Cotton-effects were observed.
    Notizen: Zusammenfassung In neutralen wäßrigen Lösungen, die Amylose und Kongorot enthalten, treten im Bereich der Absorptionsmaxima Abweichungen von der normalen optischen Rotationsdispersion und mehrere induzierte Cotton-Effekte auf. Hieraus wird auf eine geordnete Assoziation der Farbstoffmoleküle an helicale Segmente der Amylose geschlossen. Bei Methylorange, β-Naphtholorange und Chrysophenin G sind keine induzierten Cotton-Effekte zu beobachten.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02133312
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  • 10
    Digitale Medien
    Digitale Medien
    1 3C-NMR-Spektroskopie an Polyäthern (1974)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 86 (1974), S. 450-450 
    Details
    ISSN: 0044-8249
    Schlagwort(e): Chemistry ; General Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ange.19740861216
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