In:
Gynecologic and Obstetric Investigation, S. Karger AG, Vol. 7, No. 5 ( 1976), p. 293-305
Kurzfassung:
Catecholamines bind specifically to several cell types and subcellular fractions. This binding is not consistent with binding to the adrenergic receptor. Catecholamines would be expected to bind to sites other than the adrenergic receptor (uptake 1, uptake 2, nerve vesicles, catecholamine-O-methyl transferase and serum albumin). We characterized the binding of 〈 sup 〉 3 〈 /sup 〉 H-norepinephrine to microsomes prepared from rabbit myometrium. In the presence of antioxidant binding was reversible and 〈 sup 〉 3 〈 /sup 〉 H-norepinephrine could be recovered bound to microsomes or free in incubation media. The binding was not characteristic of binding to any one known biological site. It may represent binding to a mixture of these sites or may be fortuitous binding to sites of unknown biological significance.
Materialart:
Online-Ressource
ISSN:
0378-7346
,
1423-002X
Sprache:
Englisch
Verlag:
S. Karger AG
Publikationsdatum:
1976
ZDB Id:
1482695-1
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