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  • 1
    Electronic Resource
    Electronic Resource
    Binding of [3H] γ-Aminobutyric Acid and [3H]Muscimol in Purified Rat Brain Synaptic Plasma Membranes and the Effects of Bicuculline (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 39 (1982), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The binding of [3H] γ-aminobutyric acid ([3H]GABA) and [3H]muscimol has been studied in purified synaptic plasma membrane (SPM) preparations from rat brain. Scatchard analysis of specific binding (defined as that displaced by 100 μMγ-aminobutyrate) indicated that the binding of both radiolabelled ligands was best described by a two component Langmuir adsorption isotherm. The apparent KD and Bmax values for [3H]GABA at 4°C were KD1, 20 nM; KD2,165 nM; Bmax1, 0.48 pmol;Bmax2, 6.0 pmol. mg−1; for [3H]muscimol at 4°C they were: KD1, 1.75 nM; KD2, 17.5 nM; Bmaxl, 0.84 pmol. mg−1; Bmax2, 4.8 pmol.mg−1; and for [3H]muscimol at 37°C they were: KD1, 7.0 nM; Km, 60 nM; Bmax], 0.5 pmol-mg−1; Bmax2, 7.2 pmol-mg1. Under the experimental conditions used, the similar Bmilx values for [3H]GABA and [3H]muscimol binding to the SPM preparations suggests that the high- and low-affinity components for the two radiolabeled ligands are identical. The effects of the GAB A antagonist bicuculline on the binding of [3H]muscimol at 4CC and 37°C were studied. At 4°C, antagonism of muscimol binding appeared to be competitive at the high-affinity site but noncompetitive at the low-affinity site. At 37°C, antagonism was again competitive at the high-affinity site but was of a mixed competitive/noncompetitive nature at the low-affinity site. Assuming that binding to the high-affinity site is associated with the pharmacological actions of bicuculline, the apparent KD values obtained suggest a pA2 value of 5.3 against [3H]muscimol at 4°C and 37°C. This figure is in good agreement with several estimates of the potency of bicuculline based on pharmacological measurements. Results from displacement studies using [3H]GABA and [3H]muscimol suggest that [3H]GABA might be a more satisfactory ligand than [3H]muscimol in GABA radioreceptor assays.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1982.tb04700.x
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  • 2
    Electronic Resource
    Electronic Resource
    Cardiovascular responses to anaesthesia (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 35 (1980), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Observations of heart rate, rhythm and arterial pressure during induction of anaesthesia, intubation of the trachea, and commencement of surgery were made in 42 patients divided into three comparable groups. Group 1, the control group of 15 patients, received an intravenous placebo injection prior to induction of anaesthesia; group 2, 14 patients, was given an intravenous injection of 2 mg of metoprolol, a beta-adrenoreceptor blocking agent; group 3, 13 patients, received 4 mg metoprolol intravenously. In the placebo group, significant mean increases in heart rate of 27 and 38 beats/minute were noted at induction of anaesthesia and at intubation of the trachea respectively (p〈 0·001). Heart rate was significantly reduced after metoprolol in groups 2 and 3 before anaesthesia (7·6 beats/minute, p 〈 0·05; and 12·9 beats/minute, p 〈 0·001). The increases which occurred after induction of anaesthesia (13·7 beats/minute, p 〈 0·01; and 15 beats/minute, p 〈 0·001), were significantly less than those in the control group (p 〈 0·05). Further increases in heart rate of 10 and 11 beats/minute were noted at intubation in groups 2 and 3 respectively (significantly less than placebo, p〈 0·05).Although no change in systolic arterial pressure was noted in the control group following induction of anaesthesia and the mean increase after intubation was modest (9·8 mmHg), increases in three patients exceeded 50 mmHg. Arterial pressure was reduced by metoprolol in the period before anaesthesia in groups 2 and 3 by 7·1 mmHg (p〈 0·05) and 8·1 mmHg (p 〈 0·01). Again no changes were noted at induction. Mean increases in blood pressure after intubation did not exceed control levels, and increases of 20–30 mmHg were noted in six patients.Cardiac rhythm disturbances, of short duration and of no apparent clinical consequence, were noted in association with induction of anaesthesia and intubation. ST segment changes were commonest and occurred in eight patients; five of these were in the placebo group. Six patients had short-lived ventricular and supraventricular ectopics at induction or intubation of the trachea.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1980.tb04995.x
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  • 3
    Electronic Resource
    Electronic Resource
    Alcohol induced discoordination is not reversed by naloxone (1981)
    Springer
    Psychopharmacology 75 (1981), S. 65-68 
    Details
    ISSN: 1432-2072
    Keywords: Naloxone ; Alcohol ; Sensory-motor discoordination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract It has previously been reported that prior administration of naloxone may prevent the decrement in performance produced by alcohol. To be of clinical value, however, naloxone must be shown to reverse rather than prevent this decrement. This study examined the effect of naloxone given after consumption of alcohol. A double blind balanced crossover protocol was used to examine the effect of either 1.2 mg or 10 mg naloxone on the sensory-motor impairment produced by blood alcohol concentrations maintained between 75 and 85 mg/100 ml. This alcohol concentration significantly impaired two measures of sensory-motor performance, but there was no evidence that either dose of naloxone could reverse this decrement. We tested our subjects for a chlorpropamide alcohol flush but none gave a positive response. These results indicate that naloxone (1.2 mg or 10 mg) does not reverse the sensory-motor impairment produced by alcohol intoxication in subjects who do not exhibit a chlorpropamide alcohol flush. Nearly all the subjects exhibited somnolence after receiving alcohol and naloxone (1.2 mg or 10 mg) but not after receiving alcohol and saline.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00433504
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  • 4
    Electronic Resource
    Electronic Resource
    Electron densities in active galaxies (1983)
    [s.l.] : Nature Publishing Group
    Nature 306 (1983), S. 503-503 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IT is alarming to find a common fallacy concerning the measurement of electron densities in astrophysical conditions appearing twice in the same issue of Nature. Both Fairall1 and Gaskell2, argue that the mere appearance ofthe forbidden lines of O III in a Seyfert galaxy can place an upper limit ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/306503a0
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  • 5
    Electronic Resource
    Electronic Resource
    Solar physics at Oxford (1981)
    [s.l.] : Nature Publishing Group
    Nature 292 (1981), S. 194-195 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE growing importance of solar physics within astronomy was illustrated by a recent meeting* at Oxford which took as its theme 'Solar Activity'. Topics ranged from the underlying causes of solar activity in the interaction between the sub-photospheric convection zone and magnetic fields to the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/292194a0
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  • 6
    Electronic Resource
    Electronic Resource
    H 2 emission in the EUV spectrum of T Tauri and Burnham's nebula (1981)
    [s.l.] : Nature Publishing Group
    Nature 290 (1981), S. 34-36 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] T Tau is a pre-main-sequence star, with a photospheric absorption spectrum consistent with a spectral type of KO or K1 according to Kuhi3. It is embedded in nebulosity, from which characteristic low-excitation lines are observed in the visible region of the spectrum4. Emission from the v" = 1-0S(l) ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/290034a0
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  • 7
    Electronic Resource
    Electronic Resource
    The substance P receptor on rat mast cells and in human skin (1984)
    Springer
    Inflammation research 14 (1984), S. 420-424 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract (D-Pro4 D-Trp7,9,10)SP4–11 (SPA) has been shown to be a competitive antagonist of the histamine releasing action of substance P in rat peritoneal mast cells. Antagonist activity of SPA is expressed in the concentration range 1 to 10 μM, but at higher concentrations SPA releases histamine. SPA inhibits the flare response induced by substance P in human skin but is without effect on the wheal response. Up to 12.5 pmol SPA produces neither wheal nor flare response by itself. The structurally related peptide, kassinin, does not cause histamine release from rat mast cells at concentrations up to 10 μM whereas the methyl ester of substance P was found to 1.6 times more active than substance P in this respect. The findings are discussed in terms of the classification of substance P receptors and the mechanism of wheal and flare in human skin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01973842
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  • 8
    Electronic Resource
    Electronic Resource
    The active sun (1981)
    Springer
    Space science reviews 29 (1981), S. 363-365 
    Details
    ISSN: 1572-9672
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A brief summary is given of observations which will be required to investigate further the structure and energy balance of active regions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00239477
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  • 9
    Electronic Resource
    Electronic Resource
    Report of the work group on Latin American forests (1982)
    Springer
    Plant and soil 67 (1982), S. 415-420 
    Details
    ISSN: 1573-5036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02182791
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  • 10
    Electronic Resource
    Electronic Resource
    The nitrogen cycle in a ‘Terra Firme’ rainforest on oxisol in the Amazon territory of Venezuela (1982)
    Springer
    Plant and soil 67 (1982), S. 325-332 
    Details
    ISSN: 1573-5036
    Keywords: Amazonas ; Denitrification ; N-conservation mechanisms ; N-cycling ; N2-fixation ; Oxisol ; Rainforest ; Venezuela
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Description / Table of Contents: Resumen Los contenidos y flujos de nitrógeno, incluyendo fijación de nitrógeno y denitrificación, se midieron en un bosque lluvioso tropical que crece sobre oxisoles en el Territorio Amazonas de Venezuela. El contenido de nitrógeno era comparable con el de bosques templados, pero era más elevado que en un bosque adyacente sobre spodosoles. Los flujos eran más elevados que en bosques de zonas templadas, pero más bajos que en otro bosque tropical de suelos más fértiles. A pesar de que el nitrógeno era abundante, esto no significa que este elemento no podría ser un factor limitante para la agricultura si el bosque se corta, y se cultiva la tierra. Los mecanismos de fijación y conservación de nitrógeno dependen de la estructura del bosque no perturbado, y la destrucción del bosque eventualmente disminuiría el suministro de nitrógeno al suelo.
    Notes: Abstract Standing stocks and fluxes of nitrogen, including nitrogen fixation and denitrification, were measured in a tropical rainforest on Oxisol in the Amazon Territory of Venezuela. The standing stock of nitrogen was comparable to that of temperate forests, but was higher than that in an adjacent forest on Spodosol. Fluxes were higher than in forests in the temperate zone, but lower than in another tropical forest on more fertile soil. Even though nitrogen was abundant, this does not mean that nitrogen could not be limiting to agriculture if the forest is cleared and the land cultivated. The nitrogen fixing and nitrogen conserving mechanisms are dependent upon the structure of the undisturbed forest, and destruction of the forest would eventually decrease the input of nitrogen to the soil.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02182779
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