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  • 1985-1989  (2)
Document type
Keywords
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Diprafenone for treatment of Wolff-Parkinson-White syndrome (1989)
    Springer
    Cardiovascular drugs and therapy 3 (1989), S. 73-79 
    Details
    ISSN: 1573-7241
    Keywords: Wolff-Parkinson-White syndrome ; diprafenone ; antiarrhythmic drugs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of intravenous (1.5 to 2.0 mg/kg body weight) and oral (300 to 375 mg/d) diprafenone was studied in 15 patients with the Wolff-Parkinson-White syndrome and symptomatic supraventricular tachycardia. Intravenous application of diprafenone significantly increased atrioventricular nodal conduction time as well as the effective refractory periods of the right ventricle and the accessory pathway in both the antegrade and retrograde directions. Antegrade conduction block in the accessory pathway occurred in two patients after the dose was increased to 2.0 mg/kg body weight. Intravenous diprafenone suppressed the inducibility of supraventricular tachycardia in two patients, but the tachycardia cycle length was significantly increased in all other patients. Fourteen patients were treated with oral diprafenone, and 11 were asymptomatic during a 17-month follow-up, two of these after the dose had been increased to 375 mg/d. Oral therapy had to be withdrawn in two patients because of adverse gastrointestinal side effects and in one because of recurring bronchospasm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01881531
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Lack of correlation after reperfusion between ventricular function and infarct size estimated by thallium single-photon emission computed tomography (1988)
    Springer
    The international journal of cardiovascular imaging 3 (1988), S. 203-208 
    Details
    ISSN: 1573-0743
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In 32 patients with acute myocardial infarction, who had undergone successful intracoronary thrombolysis, the results of regional wall motion measured from contrast cineangiograms 10 to 21 days after thrombolysis were related to the results of thallium single-photon emission computed tomography (SPECT) after intravenous dipyridamole. Wall motion was measured by means of the centerline method, and thallium defect size was estimated by comparing the patient's circumferential profile with that of 20 normals. No correlation was found between ejection fraction or regional wall motion and thallium defect size. The time from symptom onset to thrombolysis was inversely correlated with the degree of hypokinesis (r=−0.51) but not with thallium defect size. In patients treated within 3 hours, hypokinesis was significantly less than in patients treated later (−1.1±0.6 SD vs −2.2±0.8 SD, p〈0.01) whereas thallium defect size was not significantly different in both groups. It is concluded that, in patients after thrombolysis, thallium defect size determined by SPECT does not reflect the degree of left ventricular dysfunction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01797718
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    Paper (German National Licenses)
    Fulltext
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