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  • 1
    Electronic Resource
    Electronic Resource
    Characterization of Newly Formed and Aged Granules in the Neurohypophysis (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 47 (1986), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract Neurosecretory granules from the rat and bovine neurohypophysis were isolated and some of their biochemical and biophysical properties studied. Neurosecretory granules (NSG) from rat neurohypophysis were labeled, in vivo, with [35S]cysteine and isolated on isoosmotic gradients. Whereas 1 day after labeling most of the radioactivity was found in the lower part of the gradient, 35 days later the isotope was also located in the lighter NSG-containing fraction. Different analytical procedures showed that the lighter fraction, both in bovine and rat NSG, contain more subpopulations of neurophysin-like material than the heavier fraction. The first material to be released during stimulation of secretion, in vivo or in vitro, is mobilized from the heavy NSG. Isolation of rat NSG, at different times during and after dehydration of the animals, reveals that the newly synthesized material is found in the heavy NSG-containing fraction. Furthermore, the results indicate that the newly synthesized NSG are more resistant to lysis than the lighter granules. The results are discussed in relation to the maturation and degradation processes of the granule content and to the functional state of the NSG.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1986.tb00791.x
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  • 2
    Electronic Resource
    Electronic Resource
    Single channels and ionic currents in peptidergic nerve terminals (1986)
    [s.l.] : Nature Publishing Group
    Nature 319 (1986), S. 410-412 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Sinus gland terminals from the land crab, Cardisoma carnifex, are easily isolated after treatment with collagenase (see Fig. 1). In electron micrographs the isolated nerve endings appear as circular profiles densely packed with neurosecretory granules (Fig. 1C). Dissociated neuronal terminals are ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/319410a0
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  • 3
    Electronic Resource
    Electronic Resource
    Relaxin affects the release of oxytocin and vasopressin from the neurohypophysis (1987)
    [s.l.] : Nature Publishing Group
    Nature 325 (1987), S. 813-816 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Figure 1 illustrates the time course of vasopressin (AVP) and oxytocin (OT) release from isolated nerve terminals in the presence or absence of 10~7 M relaxin. An increase in hormone secretion was induced by depolarizing the isolated nerve terminals (neurosecretosomes) with 100 mM K+ for 10 min. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/325813a0
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  • 4
    Electronic Resource
    Electronic Resource
    Isolated neurosecretory nerve endings as a tool for studying the mechanism of stimulus-secretion coupling (1987)
    Springer
    Bioscience reports 7 (1987), S. 411-426 
    Details
    ISSN: 1573-4935
    Keywords: neurosecretion ; nerve endings ; stimulus-secretion coupling ; secretion ; exocytosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract In the present paper we discuss the properties of a recently developed preparation of isolated neurosecretory nerve endings obtained from the rate neurohypophysis. These nerve terminals release two neurohormones, oxytocin and vasopressin, which are easily assayed by radioimmunoassay. Depolarization-induced secretion is dependent on the same parameters as those regulating release from the whole neural lobe. The isolated nerve endings can be permeabilized by means of digitonin; a treatment which gives direct access to the cytoplasm allowing the study of the minimal requirements for inducing neuropeptide release. Furthermore, some nerve endings are large enough to allow the use of the patch-clamp technique. In the present paper we present evidences which show that the isolated neurohypophysial nerve terminals represent a protent tool for studying the mechanism of stimulus-secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01362504
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  • 5
    Electronic Resource
    Electronic Resource
    Release of neuropeptides does not only occur at nerve terminals (1988)
    Springer
    Bioscience reports 8 (1988), S. 471-483 
    Details
    ISSN: 1573-4935
    Keywords: exocytosis ; secretion ; neuropeptides ; vasopressin ; neurohypophysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Neurohypophysial hormones are packed in secretory granules which are stored in nerve endings and in dilatations called nerve swellings. Although it was originally believed that the nerve swellings were storage compartments and that release occurred solely from the nerve terminals, the present paper demonstrates that secretion can occur to the same extent from both nerve endings and nerve swellings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01121646
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  • 6
    Electronic Resource
    Electronic Resource
    Are opioid peptides co-localized with vasopressin or oxytocin in the neural lobe of the rat? (1986)
    Springer
    Cell & tissue research 246 (1986), S. 177-182 
    Details
    ISSN: 1432-0878
    Keywords: Vasopressin ; Oxytocin ; Opioid peptides ; Neurosecretion ; Neural lobe ; Co-localization ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The content of vasopressin, oxytocin, neurophysin, leucine-enkephalin, methionine-enkephalin, dynorphin-(1–13), and α-neoendorphin in the rat neurohypophysis was measured after different periods of dehydration and after depolarisation of isolated neural lobes and of neurosecretory nerve endings. The rates at which the amount of neurohypophysial hormone and opioid peptides decreased, and the changes in the ratios between the amount of vasopressin or oxytocin and opioid peptide in the neurohypophysis after dehydration and in the incubation medium after depolarization in vitro cast some doubt on, and can be explained by mechanisms other than co-localisation of the different peptides.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00219015
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  • 7
    Electronic Resource
    Electronic Resource
    Ultrastructural changes in isolated peptidergic nerve terminals induced by digitonin permeabilization and K+ stimulation in the sinus gland of the crab, Cardisoma carnifex (1986)
    Springer
    Cell & tissue research 246 (1986), S. 365-371 
    Details
    ISSN: 1432-0878
    Keywords: Neurosecretion ; Sinus gland ; Isolated nerve endings ; Potassium stimulation ; Digitonin permeabilization ; Cardisoma carnifex
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The preparation of isolated peptidergic nerve terminals from the sinus gland (a neurohemal organ) of the crab (Cardisoma carnifex) is described. In this species the nerve endings can have diameters up to 30 μm. They release neurosecretory material as judged by the decrease in the volumetric density of granules upon depolarization with potassium. Similar results were obtained after permeabilization of the nerve terminals with digitonin, but only in the presence of micromolar concentrations of calcium. This preparation should prove useful in correlating electrical events with other cellular processes involved in stimulus-secretion coupling.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00215899
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