In:
Tumori Journal, SAGE Publications, Vol. 76, No. 2 ( 1990-04), p. 179-181
Abstract:
5-Fluorouracil, a drug mainly used in the treatment of gastrointestinal tract neoplasms, was administered i.p. to BALB/c mice at the dose of 30 mg/kg body weight once a week for 50 weeks to test its carcinogenicity. The treatment induced a significant increase in lung tumor in both sexes (males, p 〈 0.05; females, p 〈 0.01) and tumors of the lymphoreticular system in female mice (p 〈 0.001). These results suggest that 5-fluorouracil is carcinogenic in mice.
Type of Medium:
Online Resource
ISSN:
0300-8916
,
2038-2529
DOI:
10.1177/030089169007600205
Language:
English
Publisher:
SAGE Publications
Publication Date:
1990
detail.hit.zdb_id:
280962-X
detail.hit.zdb_id:
2267832-3
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