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  • Blackwell Publishing Ltd  (7)
  • American Chemical Society (ACS)
  • 1995-1999  (7)
  • 1
    Digitale Medien
    Digitale Medien
    Provocative Testing in Children with Suspect Congenital Long QT Syndrome (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of noninvasive electrocardiology 3 (1998), S. 0 
    Details
    ISSN: 1542-474X
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: This study was designed to evaluate several alternative ECG measurements and provocative tests in order to identify markers for children with suspect congenital long QT syndrome (LQTS).〈section xml:id="abs1-2"〉〈title type="main"〉BackgroundA single QTc measurement on a resting ECG does not identify all children with LQTS. Alternative ECG measurements have been established for identification of LQTS patients, with varied degrees of accuracy. Additionally, findings of QT prolongation during exercise or catecholaminergic stimulation have been suggested as indicators for the presence of LQTS and associated arrhythmias.〈section xml:id="abs1-3"〉〈title type="main"〉MethodsThe ECGs from 40 children with suspect congenital LQTS were compared with 1000 gender and age matched control patients. Complete exercise ECG studies were performed on 32 of the 40 suspect LQTS patients and compared with 29 controls. ECGs recorded during isoproterenol infusion were obtained in 9 suspect LQTS patients and compared with 44 matched control subjects.〈section xml:id="abs1-4"〉〈title type="main"〉ResultsDuring exercise, the QTc was mildly prolonged in both groups, without a similar increase in JTc, suggesting prolongation of depolarization time. QT and JT dispersion shortened with exercise in control subjects, but not in the suspect LQTS patients. During isoproterenol infusion, the QTc and JTc are prolonged in the suspect LQTS group, without an increase in the control patients.〈section xml:id="abs1-5"〉〈title type="main"〉ConclusionsWe describe the ECG findings with provocative testing in patients in whom there is a clinical suspicion of LQTS, yet have a normal or borderline QTc. Exercise or isoproterenol may aid in identification of patients with congenital long QT syndrome.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1542-474X.1998.tb00023.x
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Effects of Multisite Ventricular Pacing on Cardiac Function in Normal Dogs and Dogs with Heart Failure (1999)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cardiovascular electrophysiology 10 (1999), S. 0 
    Details
    ISSN: 1540-8167
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Multisite Ventricular Pacing in Heart Failure. Introduction: We studied the effects on cardiac function of pacing two right and two left ventricular sites in normal and failing hearts with a normal QRS duration. Methods and Results: Hemodynamic parameters were studied in isoflurane-anesthetized dogs with normal hearts and dogs with heart failure induced by rapid ventricular pacing. Unipolar intramyocardial electrodes were placed at the high right atrium and the apex (A) and base (B) of the left (L) and right (R) ventricles (V). Data were collected after pacing for 5 to 20 minutes. In normal dogs, without bundle branch block (BBB), pacing at either the apex or the base of the left ventricle increased cardiac output by approximately 10% compared with right ventricular apex (RVA) pacing with an AV delay of 10 msec. Positive dP/dt increased approximately 10% during four-site left and right ventricular apex and base (LRVAB) pacing compared with RVA pacing. In dogs with heart failure but without BBB, cardiac output increased by 8.5% (P 〈 0.01) during four-site ventricular pacing with AV delays of 0 and 60 msec compared with RVA pacing. Positive dp/dt increased by 23.5% (P 〈 0.001) with an AV delay of 0 msec and 9.6% (P 〈 0.001) with an AV delay of 60 msec during LRVAB pacing compared with RVA pacing. His-bundle pacing was associated with increased cardiac output compared with RVA pacing. Conclusions: We conclude that pacing simultaneously at two right and two left ventricular sites significantly improves cardiac function compared with single RVA pacing, with or without sequential AV synchrony, in dogs with rapid ventricular pacing-induced heart failure and no BBB.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1540-8167.1999.tb01264.x
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Inheritance of sesquiterpene lactone types within the Achillea millefolium complex (Compositae) (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Plant breeding 116 (1997), S. 0 
    Details
    ISSN: 1439-0523
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft
    Notizen: Successful crossing experiments between tetraploid individuals of Achillea ceretanica, A. collina, A. distans ssp. styriaca, and A. pratensis (A. millefolium complex, Compositae) were carried out. Sesquiterpenes of 1013 hybrid plants obtained from 13 crossings were studied by qualitative thin layer chromatography (TLC). F1-progenies from parent plants with guaianolides (GU-type), as well as the offspring of a back-cross, uniformly contained proazulenes. Diallel crosses between plants exclusively with eudesmanolides (EU-type) resulted in a 7:1 segregation-ratio of EU- and GU-plants. Two reciprocal crossing experiments between EU- and GU-parents resulted in 28.6% and 89.3% EU-individuals, as well as GU-offspring. According to these findings, the qualitative marker ‘proazulene’ (GU-type) is thought to be a recessive character of the tetraploid Achillea species studied.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1439-0523.1997.tb00979.x
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Alcohol consumption: a risk factor for abdominal fat accumulation in men (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Addiction biology 2 (1997), S. 0 
    Details
    ISSN: 1369-1600
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract An increased abdominal fat mass is regarded as an independent cardiovascular risk factor. In this cross-sectional study of 1099 men we found a significant positive association between alcohol intake and the waist/hip (W/H) ratio, an index for the abdominal fat mass. This relationship was independent of age and body weight. The results suggest that the risk of abdominal fat deposition could be minimized by a reduction of alcohol intake.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1080/13556219772912
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    QT and JT Dispersion in Children with Long QT Syndrome (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cardiovascular electrophysiology 8 (1997), S. 0 
    Details
    ISSN: 1540-8167
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: QT and JT Dispersion in Long QT Syndrome. Introduction: Abnormalities of ventricular repolarization leading to ventricular arrhythmias place children with long QT syndrome at high risk for sudden death. Dispersion of the QT (QTd) and JT (JTd) intervals, as markers of cardiac electrical heterogeneity, may be helpful in evaluating children with long QT syndrome and identifying a subset of patients at high risk for development of critical ventricular arrhythmias (ventricular tachycardia, torsades de pointes, and/or cardiac arrest).Methods and Results: The QTd and JTd intervals in 39 children with long QT syndrome were compared to those of 50 normal age-matched children. In the long QT syndrome group, QTd measured 81 ± 70 msec compared to 28 ± 14 msec in the control group (P 〈 0.05), and JTd in the long QT syndrome group was 80 ± 69 msec compared to 25 ± 15 msec in the control group (P 〈 0.05).Conclusion: Children with long QT syndrome have an increased QTd and JTd when compared to normal controls. A QTd or JTd ≥ 55 msec correlates with the presence of critical ventricular arrhythmias. These ECG measures of dispersion can be useful in stratifying children with the long QT syndrome who are at higher risk for developing critical ventricular arrhythmias.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1540-8167.1997.tb01827.x
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
    Digitale Medien
    Digitale Medien
    Low Temperature and Low Energy Radiofrequency Modification of Atrioventricular Nodal Slow Pathways in Pediatric Patients (1999)
    Oxford, UK : Blackwell Publishing Ltd
    Pacing and clinical electrophysiology 22 (1999), S. 0 
    Details
    ISSN: 1540-8159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Objectives: To report our experience using low temperature and energy in the modification of the slow pathway in pediatric patients with atrioventricular nodal reentrant tachycardia. Background: A concern in performing a slow pathway modification is the possible damage of the normal AV conduction system. Lesion size has been shown to have a linear relationship with temperature. Previous reports have used energy of 25–50 W that generate temperatures of 60C°–70°C for successful procedures. Methods: Report of results of attempted AV nodal slow pathway modification in 17 consecutive pediatric patients 〈 15 years of age at The Children's Hospital of Philadelphia from April 1995 to November 1997 using low temperature and energy. Results: There were 18 successful slow pathway modifications with 1 recurrence in 17 patients. The maximum energy used during successful lesions was 32.7 ± 13.8 W (range 15–50 W) with a mean energy of 26.4 ± 13.3 W (range 12–48 W). The peak temperature during these lesions was 55.1°C ± 4.1°C (range 48°C–64°C) with a mean temperature of 47.9°C ± 2.7°C (range 44°C–54°C). The mean number of radiofrequency lesions required for a successful modification was 5.8 ± 6.7 (median 4.0, range 1–26). Patients have been followed for 2.08 ± 0.79 years. Conclusions: Slow pathway modification can be performed successfully with a low incidence of recurrence in the pediatric patient using low energy and temperature. It is possible that this may lead to smaller lesions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1540-8159.1999.tb00572.x
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
    Digitale Medien
    Digitale Medien
    Role of the Cardiac Sarcolemmal Na+-Ca2+ Exchanger in End-Stage Human Heart Failure (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 779 (1996), S. 0 
    Details
    ISSN: 1749-6632
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1749-6632.1996.tb44833.x
    Standort Signatur Einschränkungen Verfügbarkeit
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