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  • 2000-2004  (11)
Document type
Keywords
Publisher
Language
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Year
  • 1
    Online Resource
    Online Resource
    Genes and Mechanisms in Vertebrate Sex Determination. (2001)
    Basel :Springer Basel AG,
    Details
    Keywords: Sex determination, Genetic. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (210 pages)
    Edition: 1st ed.
    ISBN: 9783034877817
    Series Statement: Experientia Supplementum Series ; v.91
    URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=3086220
    Language: English
    Note: Intro -- EXS 91 -- Editor's page -- Copyright -- Contents -- List of contributors -- Preface -- The one-to-four rule and paralogues of sex-determining genes -- Genes essential for early events in gonadal development -- Sry, Sox9 and mammalian sex determination -- DAX-1, an "antitestis" gene -- Sex chromosomes and sex-determining genes: insights from marsupials and monotremes -- An overview of factors influencing sex determination and gonadal development in birds -- Temperature-dependent sex determination and gonadal differentiation in reptiles -- Sex chromosomes, sex-linked genes, and sex determination in the vertebrate class Amphibia -- Endocrine and environmental aspects of sex differentiation in gonochoristic fish -- Index.
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    GEOMAR EBL
  • 2
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    Carbon analysis of surface sediments from the Laptev Se (2001)
    PANGAEA
    In:  Supplement to: Fahl, Kirsten; Cremer, Holger; Erlenkeuser, Helmut; Hanssen, Hinrich; Hölemann, Jens A; Kassens, Heidemarie; Knickmeier, Karin; Kosobokova, Ksenia N; Kunz-Pirrung, Martina; Lindemann, Frank; Markhaseva, Elena; Lischka, Silke; Petryashov, Victor; Piepenburg, Dieter; Schmid, Michael K; Spindler, Michael; Stein, Ruediger; Tuschling, Kirsten (2001): Sources and pathways of organic carbon in the modern Laptev Sea (Arctic Ocean): implications from biological, geochemical and geological data. Polarforschung, 69, 193-205, hdl:10013/epic.29844.d001
    Details
    Publication Date: 2024-04-16
    Description: During the past six years organic geochemical, micropaleontological, and sedimentological investigations were carried out within the framework of the multidisciplinary bilateral German-Russian research project ''System Laptev Sea'' and detailed biological investigations within the project ''German-Russian Investigations of the Marginal Seas of the Eurasian Arctic'', In order to understand the Laptev Sea ecosystem and to obtain information about sources and fate of organic carbon, the distribution of phyto- and zooplankton, diatoms, chlorophyll a benthic macrofauna, palynomorphs, grain size, total organic carbon, d13Corg and biomarkers (n-alkanes, fatty acids) were determined. In general, the influence of the major rivers draining into the Laptev Sea, is reflected in the water column as well as in the surface sediments. In both habitats three ecological provinces can be distinguished, i.e., the southeastern Laptev Sea, the central Laptev Sea, and the northern Laptev Sea. Additionally, clear differences between the western and the eastern Laptev Sea occur. The comparison of the different data sets of the water column and the surface sediments provide information about organic carbon sources and pathways in the Laptev Sea shelf and continental slope area.
    Keywords: AWI_Paleo; BCR; Box corer (Reineck); Carbon, organic, total; CTD/Rosette; CTD-RO; DEPTH, sediment/rock; Element analyser CHN, LECO CNS 2000; Elevation of event; Event label; GEOMAR; Giant box corer; GKG; Grab; GRAB; Helmholtz Centre for Ocean Research Kiel; IK9301-6; IK9306-6; IK9309-4; IK9313-6; IK9315-1; IK9316-6; IK9318-3; IK9320-1; IK9321-5; IK9323-6; IK9324-4; IK9330-2; IK9334-7; IK9338-5; IK9340-6; IK9342-6; IK9344-8; IK9346-4; IK9348-6; IK9353-9; IK9356-2; IK9358-5; IK9365-6; IK9367-2; IK9370-12; IK9371-1; IK9373-8; IK9373A-6; IK9382-6; IK9384-1; IK93K1-1; IK93K2-1; IK93Z3-3; IK93Z4-4; IK93Z5-3; Isotope ratio mass spectrometry; Ivan Kireyev; Kapitan Dranitsyn; KD9502-12; KD9509-6; KD9510-3; KD9517-3; KD9523-7; KD9529-11; KD9533-10; KD9541-12; KD9548-11; KD9555-10; KD9560-5; KD9561-3; KD9565-11; KD9568-7; KD9572-1; Laptev Sea; LATITUDE; Lena Nordenskøld Station; LN9604-8; LN9604-9; LN9605-8; LN9605-9; LN9606-10; LN9606-9; LN9608-12; LN9609-14; LN9610-11; LN9611-12; LN9612-8; LN9613-8; LN9614-7; LN9615-5; LN9616-7; LN9617-8; LN9618-8; LN9619-9; LN9620-12; LN9621-11; LN9622-8; LN9623-10; LN9624-10; LN9625-10; LONGITUDE; Paleoenvironmental Reconstructions from Marine Sediments @ AWI; Photo/Video; PM9402-3; PM9417-4; PM9441-4; PM9442-3; PM9462-1; PM9463-8; PM9475-3; PM9481-2; PM9482-1; PM9492-3; PM9494-5; PM9499-1; Professor Multanovskiy; PV; Quaternary Environment of the Eurasian North; QUEEN; Siberian River Run-Off; SIRRO; Transdrift-I; Transdrift-II; Transdrift-III; Transdrift-IV; van Veen Grab; VGRAB; δ13C, organic carbon
    Type: Dataset
    Format: text/tab-separated-values, 170 data points
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    DATA PANGAEA
  • 3
    Electronic Resource
    Electronic Resource
    The VirB type IV secretion system of Bartonella henselae mediates invasion, proinflammatory activation and antiapoptotic protection of endothelial cells (2004)
    Oxford, UK : Blackwell Science Ltd
    Molecular microbiology 52 (2004), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Bartonella henselae is an arthropod-borne zoonotic pathogen causing intraerythrocytic bacteraemia in the feline reservoir host and a broad range of clinical manifestations in incidentally infected humans. Remarkably, B. henselae can specifically colonize the human vascular endothelium, resulting in inflammation and the formation of vasoproliferative lesions known as bacillary angiomatosis and bacillary peliosis. Cultured human endothelial cells provide an in vitro system to study this intimate interaction of B. henselae with the vascular endothelium. However, little is known about the bacterial virulence factors required for this pathogenic process. Recently, we identified the type IV secretion system (T4SS) VirB as an essential pathogenicity factor in Bartonella, required  to  establish  intraerythrocytic  infection  in the mammalian reservoir. Here, we demonstrate that the VirB T4SS also mediates most of the virulence attributes associated  with  the  interaction  of B. henselae during the interaction with human endothelial cells. These include: (i) massive rearrangements of the actin cytoskeleton, resulting in the formation of bacterial aggregates and their internalization by the invasome structure; (ii) nuclear factor κB-dependent proinflammatory activation, leading to cell adhesion molecule expression and chemokine secretion, and (iii) inhibition of apoptotic cell death, resulting in enhanced endothelial cell survival. Moreover, we show that the VirB system mediates cytostatic and cytotoxic effects at high bacterial titres, which interfere with a potent VirB-independent mitogenic activity. We conclude that the VirB T4SS is a major virulence determinant of B. henselae, required for targeting multiple endothelial cell functions exploited by this vasculotropic pathogen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.2003.03964.x
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Isolation and phylogenetic analysis of bacteria with antimicrobial activities from the Mediterranean sponges Aplysina aerophoba and Aplysina cavernicola (2001)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology ecology 35 (2001), S. 0 
    Details
    ISSN: 1574-6941
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The aim of this study was to isolate bacteria with antimicrobial activities from the marine sponges Aplysina aerophoba and Aplysina cavernicola. The obtained 27 isolates could be subdivided into eight phylogenetically different clusters based on comparative sequence analysis of their 16S rDNA genes. The sponge isolates were affiliated with the low (Bacillus) and high G+C Gram-positive bacteria (Arthobacter, Micrococcus), as well as the α-Proteobacteria (unknown isolate) and γ-Proteobacteria (Vibrio, Pseudoalteromonas). One novel Bacillus species was identified and two species were closely related to previously uncharacterized strains. Isolates with antimicrobial activity were numerically most abundant in the genera Pseudoalteromonas and the α-Proteobacteria. The sponge isolates show antimicrobial activities against Gram-positive and Gram-negative reference strains but not against the fungus Candida albicans. A general pattern was observed in that Gram-positive bacteria inhibited Gram-positive strains while Gram-negative bacteria inhibited Gram-negative isolates. Antimicrobial activities were also found against clinical isolates, i.e. multi-resistant Staphylococcus aureus and Staphylococcus epidermidis strains isolated from hospital patients. The high recovery of strains with antimicrobial activity suggests that marine sponges represent an ecological niche which harbors a hitherto largely uncharacterized microbial diversity and, concomitantly, a yet untapped metabolic potential.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6941.2001.tb00816.x
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    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Nucleic acid-based, cultivation-independent detection of Listeria spp. and genotypes of L. monocytogenes (2003)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS immunology and medical microbiology 35 (2003), S. 0 
    Details
    ISSN: 1574-695X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Based on comparative analysis of 16S rRNA gene sequences, two oligonucleotide probes for in situ detection of all members of the genus Listeria were designed. These probes allowed fast and reliable in situ detection of Listeria spp. even in complex samples like raw milk. Almost full-length iap (invasion-associated protein) gene sequences were determined for 69 Listeria monocytogenes strains of all 13 known serotypes. A comparison of these sequences revealed that the L. monocytogenes strains can be grouped into three distinct genotypes. These clusters correlate well with distinct serotypes. Thus, strains of serotypes b and d belong to genotype I, a and c to genotype II, and 4a and 4c, which are rarely isolated from humans, group together within genotype III. These results could be corroborated by further comparative sequence analysis of genes encoding two phospholipases –plcA and plcB. Based on the iap gene sequences, a highly specific and reproducible competitive PCR detection method was developed. Primer pairs targeting genotype-specific regions of the iap gene were designed. The amplification of non-specific PCR products from DNA of non-target strains was prevented by adding competitive primers. By applying this method, the rapid and reliable distinction of the three L. monocytogenes genotypes was possible.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0928-8244(02)00456-X
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    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    A bisexually reproducing all-triploid vertebrate (2002)
    [s.l.] : Nature Publishing Group
    Nature genetics 30 (2002), S. 325-328 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Green toads are common in the Palaearctic region, where they have differentiated into several taxa. The toads exist with variable amounts of ploidy, similar to other anuran species or reptiles. In vertebrate biology, the very rare occurrence of triploidy is coupled with infertility or unisexuality, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng839
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    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Structure of the acrosomal bundle (2004)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 431 (2004), S. 104-107 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In the unactivated Limulus sperm, a 60-µm-long bundle of actin filaments crosslinked by the protein scruin is bent and twisted into a coil around the base of the nucleus. At fertilization, the bundle uncoils and fully extends in five seconds to support a finger of membrane known as the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature02881
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    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    hKCNN3 which maps to chromosome 1q21 is not the causative gene in periodic catatonia, a familial subtype of schizophrenia (2000)
    Springer
    European archives of psychiatry and clinical neuroscience 250 (2000), S. 163-168 
    Details
    ISSN: 1433-8491
    Keywords: Key words Human ; KCNN3 ; SKCa3 ; Chromosome ; Linkage ; Periodic catatonia ; Schizophrenia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The human calcium-activated potassium channel gene (hKCNN3, hSKCa3) contains two tandemly arranged, multiallelic CAG repeats located in exon 1 which result in short to moderate polyglutamine stretches of unknown functional significance. Case-control and family-based association studies suggested an association of hKCNN3 repeats with susceptibility for schizophrenia. Twelve multiplex pedigrees with periodic catatonia, a schizophrenia subtype with major gene effect and patterns of anticipation, were genotyped using the multiallelic hKCNN3 repeat polymorphism. Using a dominant model of inheritance with sex- and age-dependent penetrance classes, cumulative results showed exclusion of linkage of hKCNN3 to periodic catatonia under the assumption of genetic homogeneity with lod score of −48.01 at zero recombination fraction. Our results provide evidence that hKCNN3 is not the causative gene in the familial schizophrenia subtype of periodic catatonia. By fluorescent in situ hybridization we confirmed the assignment of hKCNN3 to chromosome 1q21 near the heterochromatin region. Linkage mapping showed segregation with marker DIS498 (θ=0.05) and placed hKCNN3 in the genetic linkage map in a cluster of genes near the centromeric region of chromosome 1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004060070020
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    Paper (German National Licenses)
    Fulltext
  • 9
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    Isolation and phylogenetic analysis of bacteria with antimicrobial activities from the Mediterranean sponges Aplysina aerophoba and Aplysina cavernicola (2001)
    Wiley
    In:  FEMS Microbiology Ecology, 35 (3). pp. 305-312.
    Details
    Publication Date: 2015-08-27
    Description: The aim of this study was to isolate bacteria with antimicrobial activities from the marine sponges Aplysina aerophoba and Aplysina cavernicola. The obtained 27 isolates could be subdivided into eight phylogenetically different clusters based on comparative sequence analysis of their 16S rDNA genes. The sponge isolates were affiliated with the low (Bacillus) and high G+C Gram-positive bacteria (Arthobacter, Micrococcus), as well as the α-Proteobacteria (unknown isolate) and γ-Proteobacteria (Vibrio, Pseudoalteromonas). One novel Bacillus species was identified and two species were closely related to previously uncharacterized strains. Isolates with antimicrobial activity were numerically most abundant in the genera Pseudoalteromonas and the α-Proteobacteria. The sponge isolates show antimicrobial activities against Gram-positive and Gram-negative reference strains but not against the fungus Candida albicans. A general pattern was observed in that Gram-positive bacteria inhibited Gram-positive strains while Gram-negative bacteria inhibited Gram-negative isolates. Antimicrobial activities were also found against clinical isolates, i.e. multi-resistant Staphylococcus aureus and Staphylococcus epidermidis strains isolated from hospital patients. The high recovery of strains with antimicrobial activity suggests that marine sponges represent an ecological niche which harbors a hitherto largely uncharacterized microbial diversity and, concomitantly, a yet untapped metabolic potential.
    Type: Article , PeerReviewed
    Format: text
    DOI: 10.1111/j.1574-6941.2001.tb00816.x
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    OceanRep: Article in a Scientific Journal - peer-reviewed
  • 10
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    The benthos off King George Island (South Shetland Islands, Antarctica): further evidence for a lack of a latitudinal biomass cline in the Southern Ocean. (2002)
    In:  EPIC3Polar Biology 25:, pp. 146-158
    Details
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
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    PAPER (OA)
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