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Digitale Medien

Mechanisms of cooperativity underlying sequence-independent β-sheet formation (2002)

Guo, Chinlin ; Cheung, Margaret S. ; Levine, Herbert

College Park, Md. : American Institute of Physics (AIP)

The Journal of Chemical Physics 116 (2002), S. 4353-4365

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ISSN: 1089-7690

Quelle: AIP Digital Archive

Thema: Physik , Chemie und Pharmazie

Notizen: We investigate the formation of β-sheet structures in proteins without sequence-dependent side-chain interactions. To accomplish this, we introduce a model which explicitly incorporates both solvation effects and the angular dependence (on the protein backbone) of hydrogen bond formation. The thermodynamics of this model is studied by exploring the density of states for the entire system and the local couplings in a partially folded structure. Our results suggest that solvation dynamics together with the H-bond angular dependence gives rise to a generic cooperativity in this class of systems; this result explains why pathological aggregates involving β-sheet cores can form from many different proteins. Our work provides the foundation for the construction of phenomenological models to investigate topology effects in β-sheet folding and the competition between native folding and nonspecific aggregation. © 2002 American Institute of Physics.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1063/1.1448493

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Digitale Medien

The artistry of nature (2001)

Ben-Jacob, Eshel ; Levine, Herbert

[s.l.] : Nature Publishing Group

Nature 409 (2001), S. 985-986

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] ...The endless array of patterns and shapes in nature has long been a source of joy and wonder to laymen and scientists alike. Discovering how such patterns emerge spontaneously from an orderless and homogeneous environment has been a challenge to researchers in the natural sciences throughout the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/35059178

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Digitale Medien

A Statistical Mechanics Model for Receptor Clustering (2000)

Guo, Chinlin ; Levine, Herbert

Springer

Journal of biological physics 26 (2000), S. 219-234

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ISSN: 1573-0689

Schlagwort(e): Signal transduction ; Receptor clustering ; Statistical mechanics

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Physik

Notizen: Abstract We introduce and study a simple lattice statistical mechanics modelfor the clustering of tumor necrosis factor receptor I (TNFR1).Our model explains clustering under over-expression of the cytoplasmicsignal transducer as well as the clustering induced via extracellularligand binding; also we explain why the loss of transducer leads to arapid break-up of the clusters. The basic mechanism at work is a first-order(cooperative) phase transition caused by the multimeric binding capability ofthe receptor-transducer complex. Using cooperativity of this type, the cellsare found to have an enhanced sensitivity and robustness. In general, ourmethod can be applied to other receptor-clustering related signaling system.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1023/A:1010313529687

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