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  • 2005-2009  (3)
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  • 1
    Electronic Resource
    Electronic Resource
    Vascular endothelial growth factor 121 is the predominant isoform in psoriatic scales (2005)
    Oxford, UK; Malden, USA : Munksgaard International Publishers
    Experimental dermatology 14 (2005), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract:  Vascular endothelial growth factor (VEGF) is a powerful agent that causes hyperpermeability of blood vessels as well as endothelial cell proliferation. Recent investigations have revealed that production of VEGF increases in epidermis of psoriatic lesions, and the overproduced VEGF plays an important role in the pathogenesis of psoriasis. In this study, we used immunohistochemical staining as well as extraction of stratum corneum with physiological saline to further analyse VEGF produced in psoriatic lesions. Biological activity of VEGF in the psoriatic scales was assayed by cultured human umbilical vein endothelial cells in vitro. The immunohistochemical examination confirmed an increased production of VEGF in the keratinocytes of psoriatic lesions. In addition, we found that the content of VEGF contained in the psoriatic scales was approximately 50 times greater than that in normal stratum corneum. We also found that VEGF 121 isoform, which has an exclusive ability to cause hyperpermeability of blood vessels, was predominantly detected in psoriatic scales, suggesting a major role of VEGF 121 isoform on the altered structure of microvessels in psoriatic lesions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0625.2005.00356.x
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  • 2
    Electronic Resource
    Electronic Resource
    Numerical Simulation of Semi-Solid Roll Strip-Casting Process for AZ91D Magnesium Alloy (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Solid state phenomena Vol. 141-143 (July 2008), p. 617-622 
    Details
    ISSN: 1662-9779
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Physics
    Notes: High quality magnesium alloy sheets with non-dendritic microstructure can bemanufactured by the technique which incorporates semi-solid processing with continuous roll stripcasting.In particular, the process is believed to be cost-effective in mass production of magnesiumsheet products. The processing parameters, such as roll speed and temperature, have significantinfluence on roll strip-casting process. In this paper, the commercial software, DEFORM-3D, fordeformation simulation of bulk materials was used to carry out the simulation of roll strip-castingprocess for AZ91D magnesium alloy in semi-solid state, and the distribution of equivalent stress,equivalent strain and temperature was obtained. Based on the results, the optimization of processingparameters was discussed
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/24/transtech_doi~10.4028%252Fwww.scientific.net%252FSSP.141-143.617.pdf
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  • 3
    Electronic Resource
    Electronic Resource
    Numerical Simulation of Semi-Solid Billet Preparation by Equal Channel Angular Extrusion (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Solid state phenomena Vol. 141-143 (July 2008), p. 683-688 
    Details
    ISSN: 1662-9779
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Physics
    Notes: Equal channel angular extrusion (ECAE) is a technology of refining crystal grain. In thispaper, ECAE was introduced into the preparation of semi-solid billet and the extrusion process wassimulated using finite element method. The variation of stress (mean stress, max principle stress,effective stress), the distribution of strain, the lattice change were obtained. The results show thatnot only does the shear stress exist, but also the normal stress in the extrusion process; the stressesin die inner corner of channel and outer corner of channel are not the same. In the inner corner,besides the simple shear, there are compression, and in the outer corner, tension. The strain isnon-homogeneous and appears a graded distribution
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/24/transtech_doi~10.4028%252Fwww.scientific.net%252FSSP.141-143.683.pdf
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