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  • 1
    In: American Heart Journal, Elsevier BV, Vol. 150, No. 5 ( 2005-11), p. 987-993
    Type of Medium: Online Resource
    ISSN: 0002-8703
    RVK:
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2005
    detail.hit.zdb_id: 2003210-9
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  • 2
    In: Journal of Investigative Medicine, SAGE Publications, Vol. 54, No. 8 ( 2006-12), p. 446-454
    Abstract: Eotaxin (CCL11) is a potent chemoattractant for eosinophils and lymphocytes. Apart from its functions in the eosinophilic system, eotaxin has been shown to be overexpressed in atherosclerosis. We therefore sought to determine whether chronic infection with Chlamydia pneumoniae or other infectious agents is correlated with concentrations of eotaxin or C-reactive protein since this mechanism could explain the finding that chronic infection stimulates smooth muscle cell migration and plaque development. Patients undergoing percutaneous coronary angioplasty (PCI) for acute coronary syndrome or stable angina were included in the study. Blood was drawn before PCI, at 6 weeks, and 6 and 12 months after coronary intervention. Eotaxin and C-reactive protein were determined by enzyme-linked immunosorbent assay (ELISA). Antibodies against Candida, C. pneumoniae, cytomegalovirus, Helicobacter pylori, and herpes simplex virus were measured by ELISA or immunofluorescence. Two hundred five consecutive patients undergoing PCI (stable angina, n = 136; acute coronary syndrome, n = 69) and 83 patients with normal coronary arteries were enrolled in the study. Eotaxin concentrations at inclusion were higher in patients with coronary artery disease than in control patients, p = .01, and comparable in patients with stable angina and those with acute coronary syndrome but did not correlate with C-reactive protein. Eotaxin concentrations at inclusion and during follow-up weakly correlated with concentrations of antibodies against C. pneumoniae, H. pylori, and herpes simplex virus but not with concentrations of antibodies against Candida or cytomegalovirus. Eotaxin concentrations and antibody titers against C. pneumoniae significantly increased following angioplasty and remained elevated thereafter. In conclusion, our data demonstrate that eotaxin concentrations are elevated independently from C-reactive protein in patients with coronary artery disease and correlate with antibodies against infectious agents known for chronic infection in humans.
    Type of Medium: Online Resource
    ISSN: 1081-5589 , 1708-8267
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2006
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  • 3
    Online Resource
    Online Resource
    Wiley ; 2008
    In:  Marine Ecology Vol. 29, No. 1 ( 2008-03), p. 89-105
    In: Marine Ecology, Wiley, Vol. 29, No. 1 ( 2008-03), p. 89-105
    Abstract: The upper millimeters of sediments are considered major locations of microbial colonization and activity. The goal of our study was to investigate variations of microbial communities in the uppermost sediment layers of the coastal Baltic Sea with emphasis on the complex interplay between microbiology and physico‐chemical sediment properties. We selected a high‐resolution methodological approach that combined the cryolanding sampling technique (spatial resolution of 250 μm) with microsensor‐, spectrophotometric and microscopic analyses. While the oxygen penetration depths in dark conditions ranged from 1.4 mm to 2.6 mm during the study period, this zone expanded by about 1 mm in light and could be divided into three micro‐horizons: (i) an upper zone with a high net O 2 production, (ii) an intermediate zone with increased O 2 consumption on account of light‐stimulated respiration and (iii) a lower zone with lower O 2 consumption. Time‐series experiments revealed a rapid response of the benthic microbial community to altered light intensities. In May and July, the net O 2 budget in the porewater of sediments was positive within 35 and 22 min after illumination, respectively, whereas in June O 2 production exceeded O 2 consumption after 112 min. The thickness of the O 2 production and O 2 consumption micro‐zones decreased from May to July coinciding with an increase in temperature. In May, sites of enhanced O 2 consumption were closely associated with subsurface maxima of microbial numbers and enzymatic activities indicating a tight coupling between photoautotrophic and heterotrophic processes between 1‐ and 2‐mm depth. In June and July, the microbial abundance and enzymatic activity hardly varied with depth. Spatial and temporal microheterogeneity of microbial distribution and activity in O 2 gradients was seen as a reflection of the complex interplay between microbiology and physico‐chemical sediment properties.
    Type of Medium: Online Resource
    ISSN: 0173-9565 , 1439-0485
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2008
    detail.hit.zdb_id: 2020745-1
    detail.hit.zdb_id: 225578-9
    SSG: 12
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