Publication Date:
2012-04-05
Description:
Structure of the human metapneumovirus fusion protein with neutralizing antibody identifies a pneumovirus antigenic site Nature Structural & Molecular Biology 19, 461 (2012). doi:10.1038/nsmb.2250 Authors: Xiaolin Wen, Jens C Krause, George P Leser, Reagan G Cox, Robert A Lamb, John V Williams, James E Crowe & Theodore S Jardetzky Human metapneumovirus and respiratory syncytial virus cause lower respiratory tract infections. The virus fusion (F) glycoprotein promotes membrane fusion by refolding from a metastable pre-fusion to a stable post-fusion conformation. F is also a major target of the neutralizing antibody response. Here we show that a potently neutralizing anti–human metapneumovirus antibody (DS7) binds a structurally invariant domain of F, revealing a new epitope that could be targeted in vaccine development.
Print ISSN:
1545-9993
Electronic ISSN:
1545-9985
Topics:
Biology
,
Medicine
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