In:
The Journal of Immunology, The American Association of Immunologists, Vol. 185, No. 5 ( 2010-09-01), p. 2665-2669
Kurzfassung:
The signaling and adaptor protein Homer3 plays a role in controlling immune homeostasis and self-reactivity. Homer3 is recruited to the immune synapse (IS) following TCR ligation, although the mechanisms regulating this subcellular localization are unknown. We show that Homer3 specifically associates with a novel ubiquitin-like domain in the IκB kinase (IKK) β subunit of the IKK complex. Homer3 associates with IKKβ in T cells and colocalizes with the IKK complex at the IS. However, Homer3 is not required for IKK activation, as NF-κB signaling is intact in Homer3-deficient T cells. Instead, the IKK complex recruits Homer3 to the IS following TCR engagement, and we present evidence that this association regulates actin dynamics in T cells. These findings identify a novel interaction between two major signaling proteins and reveal an unexpected NF-κB–independent function for the IKK complex in regulating the subcellular localization of Homer3.
Materialart:
Online-Ressource
ISSN:
0022-1767
,
1550-6606
DOI:
10.4049/jimmunol.0903488
Sprache:
Englisch
Verlag:
The American Association of Immunologists
Publikationsdatum:
2010
ZDB Id:
1475085-5
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