In:
Journal of Cutaneous Pathology, Wiley, Vol. 40, No. 9 ( 2013-09), p. 788-795
Kurzfassung:
Spitz nevi demonstrate a diverse spectrum of morphologies. Recently, there have been two reported examples of Spitz nevi with rosette‐like structures similar to Homer‐Wright rosettes. Rosettes have also been described in melanomas and in a proliferative nodule arising in a congenital nevus. Methods A retrospective review of 104 cases of Spitz nevi and variants (n = 51), pigmented spindle cell nevi (n = 26), combined melanocytic nevi with features of Spitz (n = 8), atypical Spitz tumor ( AST , n = 9), and spitzoid melanoma (n = 10). Results Rosette‐like structures were present in 3 of the 104 cases (2.9%), including a compound Spitz nevus, a desmoplastic Spitz nevus, and an AST . All three cases demonstrated several foci of small nests of epithelioid cells with peripherally palisaded nuclei arranged around a central area of fibrillar eosinophilic cytoplasm. Immunohistochemical staining of the three spitzoid lesions demonstrated that the rosette‐like structures express S100 protein, Melan‐A, and neuron specific enolase ( NSE ) and lacked expression of neurofilament, glial fibrillary acidic protein and synaptophysin. Conclusions While uncommon, rosette‐like structures can occur as a focal feature in Spitz nevi and AST . Rosette‐like structures may represent a normal morphologic finding in Spitz nevi, and awareness of them may prevent misdiagnosis as a neural tumor or melanoma.
Materialart:
Online-Ressource
ISSN:
0303-6987
,
1600-0560
DOI:
10.1111/cup.2013.40.issue-9
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2013
ZDB Id:
2018100-0
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