Note: Cover -- Title Page -- Copyright Page -- About the Author -- Table of Contents -- Introduction -- Chapter 1: The Premise -- Chapter 2: Our View -- Chapter 3: Fake Photos -- Chapter 4: Famous Astronauts -- Chapter 5: Laser Pointer -- Chapter 6: The Verdict -- Try This! -- Learn More -- Glossary -- Index -- Back Cover.

Note: Intro -- Foreword -- The Changing Social and Spatial Character of Public Space and Its Modus Operandi -- References -- Preface -- Acknowledgements -- Contents -- Contributors -- List of Figures -- List of Tables -- General Introduction -- Appropriation, a Brief Background -- Temporary Appropriation in the Urban Environment -- References -- Understanding Temporary Appropriation and Social Sustainability -- Introduction -- Temporary Appropriation Vs Use of the Space -- The Relationship Between Temporary Appropriation and Place -- Temporary Appropriation and Culture -- Urban Social Sustainability -- Urban Sustainability and Culture -- Past Studies About Social Sustainability -- The Missing Link -- Discussion and Conclusion -- References -- Between Assemblages and Temporary Appropriation: The Case of Mexico City -- Introduction -- Assemblage Thinking and Territorialisation -- Temporary Appropriation and Public Space -- Highly Coded City -- Cultural Assemblage -- Legal Framework Assemblage -- Analysing Assemblages -- Analysing the Legal Framework -- Analysing Visual Complexity -- Findings and Discussion -- Conclusion -- References -- Temporary Appropriation and Informality -- Introduction -- Defining Informality -- Urban Informality -- Temporary Appropriation -- Temporary Appropriation and Informality -- Discussion and Conclusion -- References -- Ongoing Appropriation: Invisible Seattle and Red May -- Introduction -- Normative Ontology and the Politics of Time -- The Politics of Transindividuality -- Red May -- Invisible Seattle -- Conclusion -- References -- Temporary Appropriation and Public Space: Assessing the CPTED Principle of Activity Support -- Introduction -- Environmental Crime Prevention, Urban Design and Public Space -- CPTED Principles -- The CPTED Principle of Activity Support -- CPTED, Territoriality and Temporary Appropriation. , Methodology -- The Case Study -- Mapping the CPTED Principle of Activity Support -- Findings and Discussion -- Quantifying Activity Support Through Signage -- Qualifying Signage and Activities -- Conclusion -- References -- Temporary Appropriation of Public Spaces: The Influence of Outdoor Comfort -- Introduction -- Climatewalk, Sensing the Environment -- Case of Rome -- Case of Singapore -- Thermal Perception and Appropriation -- Impact -- References -- Origins of Informality: Examining the Historical and Spatial Roots of Informal Day-Labor Hiring Sites -- Introduction -- Research Area and Methods -- Day Labour and Social Sustainability -- Temporary Appropriation and Day-Labour Spaces -- Day-Labour Spaces -- Case Study 1: Establishment of New Day-Labour Spaces -- Case Study 2: End of Appropriation -- Death of a Day-Labour Space -- Concluding Discussion: Social Sustainability of Day-Labour Spaces -- References -- Unsheltered Homelessness and the Right to Metabolism: An Urban Political Ecology of Health and Sustainability -- Introduction -- Metabolism -- Marx and Metabolism -- Metabolism in Urban Political Ecology -- From the Right to the City to the Right to Metabolism -- Unsheltered Homelessness and the Right to Metabolism -- Homelessness, Temporary Appropriation, and Urban Metabolism -- References -- Temporary Appropriation in Shanghai and Hong Kong: Two Study Cases Assessing the Resilience of Women Faced with the Lack of Affordable Housing -- Introduction -- Temporary Appropriation as a Strategy to Address Housing Affordability Issues in Big Cities -- Shanghai Creation of an Outdoor Domestic Landscape to Deal with the Limited Availability of Housing Space -- Temporary Social Landscape in Hong Kong -- Temporary Appropriation and Domestic Landscapes -- Conclusions -- References -- (Temporary) Appropriation (of Space), Makassar, and Urban Kampung. , Introduction -- Appropriation -- Makassar: Social Context and Public Space -- Urban Kampung: Development and Spatial Relations -- Expanding Temporary Appropriation -- Revitalising Informal Settlements and Their Environments (RISE) -- Conclusion -- References -- Extending Temporary Appropriation Through Architecture: The Role of Adaptive Reuse in Shaping New Zealand's Built Environment -- The Impacts of New Uses in the Adaptation of Historically Significant Buildings -- Understanding the Links Between Building Adaptation and Urban Design in New Zealand -- Heritage, Identity and the Appropriation of Space -- Permanence and Impermanence in the Creation of New Public and Shared Spaces -- Conclusions -- References -- Using the Street in Mexico City Centre: Temporary Appropriation of Public Space Versus Legislation Governing Street Use -- Introduction -- Temporary Appropriation in the Urban Context -- Forms of Temporary Appropriation of Public Space -- The Official Use of the Street in Mexico City Centre -- Mexican Laws and Regulations Regarding Street Use -- The View of the Authorities on Temporary Appropriation -- Summary -- Appropriation of Streets in Mexico City Centre -- Mexico City Centre: Historical Use -- Mexico City Centre: The Current Situation -- Economic Actions and Temporary Appropriation -- Other Categories of Temporary Appropriation -- Discussion -- Temporary Appropriation of the Street, and the Laws and Regulations of MCC -- The Changing Use of the Street -- Conclusion -- References -- Transforming Everyday Public Space: Human Appropriations in Search for Citizenship and Urban Well-Being -- Introduction -- Urbanity on Demand: DIY Urbanism -- Temporary Occupations Need Space: Approaching the Human Scale -- Co-designing Cities: Engaging the Experts -- Conclusion: Defining a New Urban Paradigm -- References -- General Conclusion -- References. , Why Can't We Build Cities That Make Us Feel Safe, Happy and Healthy Anymore? -- Man the Walking Animal -- Streets the Basic Building Blocks of a Place -- The Curse of the Seed -- Our Very Own Extinction Event -- There Is Light at the End of the Tunnel! Its Only About Invitations, but the Choice Is Yours -- Afterword -- Glossary of Key Terms.

Note: Front Cover -- Contents -- Back Cover.

Note: Intro -- Realidad de la virtualidad: virtualidad de la realidad -- Introducción -- Primera sección. Epistemologías -- Lo inmaterial de la contemplación estética: paradigma post-antropocéntrico sobre arte e inteligencia artificial -- El aparecer del mundo: experiencia y realidad en la neurofilosofía contemporánea -- Inmersión. Aproximaciones desde el cuerpo intermedio-quiasmo -- Segunda sección. Ecologías -- El giro inmersivo: Diseño e inmaterialidad en la pospandemia -- Realidades híbridas. Aproximaciones desde el posthumanismo débil y el arte digital -- Hongos mágicos y realidad virtual: un análisis de la incidencia de los psicotrópicos en la concepción de realidades alternativas -- Tercera sección. Prácticas artísticas -- Deconstruyendo las subjetividades virtuales desde las prácticas artísticas -- Espacialidad en la música acúsmatica: un análisis desde mi obra composicional -- Espacialidad e inmersividad en la música acusmática -- Sobre los y las autoras.

Note: Intro -- Cover -- Half-Title -- Title -- Copyright -- Dedication -- Contents -- List of figures -- List of tables -- Acknowledgments -- 1 15,000 years of climate change in the MENA: Big history, big questions -- 2 Climate change from the Younger Dryas to the Little Ice Age -- 3 The origins of agriculture, drought, and ancient empires -- 4 Drought and political-economic transformations in the ancient Near East -- 5 Cooling, water scarcity, and societal crises in ancient Mesopotamia and Egypt -- 6 Environmental fragility in the MENA from Late Antiquity to Early Modern eras -- 7 Global warming in the MENA today and in the coming decades -- 8 Climate wars - canaries in the coal mine? -- 9 Water, food, and adaptation -- 10 The end of the MENA? -- Bibliography -- Index.

Note: Intro -- Title page -- Table of Contents -- Copyright -- Dedication -- Contributors -- Preface -- Chapter 1. Huntington's disease: Clinical features, genetic diagnosis, and brain imaging -- Introduction -- Clinical course -- Juvenile Huntington's disease -- Genetic diagnosis and genetic counseling -- Imaging -- Conclusion: Clinical aspects relevant for the development of disease-modifying therapies in Huntington's disease -- List of abbreviations -- Chapter 2. Revolutionizing clinical research and communication in Huntington's disease: The Huntington's disease integrated staging system (HD-ISS) -- Introduction -- Disease classification, measurement, and staging -- The development of the HD-ISS -- Applying the HD-ISS in research: New possibilities -- Applying the HD-ISS in research: Practical questions -- Applying the HD-ISS in research: Implications for people with Huntington's disease -- Conclusion -- Chapter 3. Huntington's disease genetics: Implications for pathogenesis -- Description of inheritance -- Chromosomal mapping of the HD genetic defect and its consequences -- The HD genetic defect -- The expanded HTT CAG repeat confers a gain of function -- HD genotype-phenotype correlation -- Modifiers of HD onset from human genetics -- A model for HD pathogenesis from human genetics -- Underpinnings of the modifier effects -- Modifiers of other disease landmarks -- HD diagnostics -- What is the ultimate cause of neuronal loss? -- Potential for developing an HD treatment from genetic knowledge -- Conclusion -- Chapter 4. The instability of the Huntington's disease CAG repeat mutation -- Introduction: The critical role of CAG repeat length -- Intergenerational repeat instability -- Somatic repeat instability -- Insights into CAG repeat instability from mouse models -- Insights from human genetics -- Conclusions and perspective. , Chapter 5. Mechanisms of somatic CAG-repeat expansions in Huntington's disease -- Introduction -- Current understanding of somatic repeat instability -- Slip-out formation -- Requirement of transcription and transcription-coupled repair for somatic repeat instability -- Melting unusual structures at the repeat and modulating torsional tension -- Many nucleases can act on slipped-DNA structures which may impact repeat instability -- Gap-filling and ligation of the DNA backbone -- What is still unclear? -- Conclusion -- Chapter 6. RNA-mediated pathogenic mechanisms in Huntington's disease -- Expression of the huntingtin gene -- Regulation of huntingtin transcription -- Alternative processing of huntingtin pre-mRNA -- Nuclear RNA "clusters" and RNA "foci" in HD mouse models and HD patient samples -- Global aberrant RNA processing in HD -- RNA-based mechanism of pathogenesis -- Implications for therapy -- Chapter 7. Huntingtin protein-protein interactions: From biology to therapeutic targets -- Introduction -- Two-hybrid HTT protein interaction mapping efforts -- Cataloging of HTT interacting partners using (immuno)affinity-based purification approaches -- Compilation and computational analysis of HTT PPIs from large- and small-scale PPI mapping studies -- Outlook -- Chapter 8. Repeat-associated non-AUG (RAN) translation and Huntington's disease: Pathology, mechanistic and therapeutic perspectives -- Introduction to RAN translation -- RAN proteins in Huntington's disease -- RAN and polyGln proteins accumulate in distinct and vulnerable brain regions -- Animal models of HD and RAN translation -- RAN protein toxicity -- Mechanistic focused therapeutics -- Conclusions -- Chapter 9. Proteostasis function and dysfunction in Huntington's disease -- Introduction -- Impact of mHTT protein on HD pathology and protein aggregation propensity. , mHTT interactions with the translation machinery -- mHTT interactions with molecular chaperones -- Pathways implicated in mHTT clearance -- mHTT sequestration-beneficial or deleterious? -- A vicious cycle links proteostasis dysfunction and HD pathology -- Perspectives -- Chapter 10. Autophagy and Huntington's disease -- Introduction -- Autophagy, three pathways trafficking cytosolic cargo to the lysosome -- Autophagy: A therapeutic avenue for HD? -- Selective autophagy: No longer simply "bulk degradation" -- Dysfunctional autophagy in Huntington's disease -- Conclusion -- Chapter 11. SUMO modification in Huntington's disease: Unraveling complex mechanisms for therapeutic insights -- Introduction -- Unveiling the intricate machinery behind SUMOylation -- SUMO's journey in HD: Tracing SUMO's path in Huntington's disease research -- Guiding the way: E3 SUMO ligases and their role in regulating HTT protein dynamics -- Balancing act: How SUMO tips the scale of protein homeostasis -- SUMO at the crossroads of cellular stress: Navigating the relationship with stress granules -- Disruption of the nuclear pore and altered nucleocytoplasmic transport in HD: A role for SUMO? -- Synaptic SUMO: Bridging the gap between molecular modification and neuronal communication -- Small modifier, big role: How SUMO orchestrates DNA damage repair -- Summary and future directions: Implications for therapy -- Chapter 12. Selective vulnerability in Huntington's disease: From excitotoxicity, mitochondrial dysfunction, and transcription dysregulation to therapeutic opportunity -- Selective vulnerability in Huntington's disease -- Possible mechanisms underlying corticostriatal degeneration in HD -- Discovery of mitochondrial dysfunction in HD -- PGC-1α -- p53 and mitochondrial dysfunction in HD -- Heat Shock Transcription Factor 1 -- Peroxisome proliferator-activated receptors. , Therapeutic opportunities -- Conclusion and future directions -- Chapter 13. Pathophysiology of synapses and circuits in Huntington disease -- Clinical and genetic features of HD -- Cortical-basal ganglia-thalamic-cortical loops regulate movement and are modulated by dopamine -- Neuropathology -- Measurable subclinical changes precede definitive motor diagnosis -- Animal models of HD facilitate investigating brain changes before overt clinical diagnosis -- Striatal microcircuit synapses -- Synaptic alterations in basal ganglia nuclei downstream of striatal SPN -- Neuronal excitability -- Input-specific plasticity: Long-term potentiation and depression -- Homeostatic plasticity -- Altered corticostriatal and thalamostriatal connectivity in HD -- Cortex motor and sensory function -- Cortex reward pathways -- Targeting synaptic and circuit changes to advance therapeutics in Huntington disease -- Chapter 14. The role of glial pathology in Huntington's disease -- The role of glial progenitor cells in HD pathogenesis -- Astrocytic dysfunction in HD -- The effects of HD pathology on oligodendrocytes and myelin -- Synopsis -- Chapter 15. Systems biology study of Huntington's disease -- Introduction -- Transcriptomic profiling of HD mice -- Insights from transcriptomic studies of HD mouse models -- Mechanisms implicated in striatal transcriptinopathy in HD -- Epigenomic dysregulation in HD mice -- Application of systems biology to study HD perturbations -- Database of HD experimental data -- Conclusions and perspectives -- Chapter 16. Unbiased genome-wide approaches to identify vulnerability factors in Huntington's disease -- Yeast model screening studies -- Invertebrate model screening studies -- Mammalian cell screening studies -- Mammalian in vivo screening -- Future directions. , Chapter 17. Striatal neuronal models of Huntington's disease via direct conversion: Modeling age-dependent disease phenotypes -- MicroRNA-mediated conversion of human fibroblasts to neurons -- Age maintenance in directly reprogrammed neurons -- Recapitulation of adult-onset neuropathology of Huntington's disease using miRNAs-mediated reprogrammed neurons -- Modeling disease-stage progression of Huntington's disease -- Conclusion -- Chapter 18. Genetic mouse models to explore Huntington's disease mechanisms and therapeutic strategies -- Transgenic mHTT N-terminal fragment mouse models of HD -- Full-length mHTT knock-in mouse models -- Full-length human HTT transgenic models -- Conclusions and perspectives -- Chapter 19. Huntington's disease: From large animal models to HD gene therapy -- Introduction to Huntington's disease neuropathology -- Treatment of large animal models of HD -- Conclusions -- Chapter 20. Deep learning and deep phenotyping of HD iPSCs: Applications to study biology and test therapeutics -- Background: Complexity in biology -- A brief introduction to AI -- Applications of DL to biology -- Impact -- Chapter 21. The promise of an underappreciated therapeutic target: Sleep and circadian rhythm dysfunction in Huntington's disease -- Sleep disturbance in Huntington's disease: The evidence -- Sleep disturbance in Huntington's disease: Preclinical models -- Which comes first, HD or sleep dysfunction, and does it matter? -- Circadian-based interventions in preclinical models -- Pharmacological interventions -- Conclusions -- Chapter 22. Huntingtin lowering therapeutics -- DNA oligonucleotides -- Oligonucleotides that use RNA interference -- siRNA oligonucleotides as therapeutic agents in HD -- Gene editing to lower or correct mutant huntingtin mRNA or protein -- AAV gene delivery for Huntington's disease: Background. , Micro-RNA: Its utility for viral-based delivery to brain in HD.