Note: Intro -- Foreword -- Contents -- Abbreviations -- Human Campylobacteriosis-A Serious Infectious Threat in a One Health Perspective -- 1 Introduction -- 2 The One Health Concept: General Theory and Practical Approaches -- 3 Human Campylobacteriosis-From Clinical Investigations to Novel Treatment Options Using Innovative Murine Models of Infection -- 3.1 Human Campylobacteriosis-Basic Characteristics -- 3.2 Burden of Disease -- 3.3 Molecular Concepts of C. jejuni-Induced Intestinal Pathogenesis -- 3.4 Novel Murine Models of C. jejuni Infection Offering Detailed Investigations and Treatment Strategies for Campylobacteriosis and Associated Long-Term Sequelae -- 4 Concluding Remarks -- References -- The Data Behind Risk Analysis of Campylobacter Jejuni and Campylobacter Coli Infections -- 1 Introduction -- 2 Risk Assessment of Human Campylobacteriosis -- 2.1 Hazard Identification -- 2.2 Hazard Characterization -- 2.3 Exposure Assessment -- 2.4 Risk Characterization -- 3 Current Surveillance Strategies of Campylobacter -- 4 Risk Management -- 4.1 Control in Poultry Meat -- 4.2 Control of Campylobacter Sources Other Than Poultry Meat -- 5 Risk Communication -- 6 Concluding Remarks -- References -- Population Biology and Comparative Genomics of Campylobacter Species -- 1 Introduction -- 2 Evolution Theory and Concepts for the Genus Campylobacter -- 3 Population Structure -- 3.1 Diversity and Population Structure of C. Jejuni and C. Coli -- 3.2 Inter Species Recombination and Hybrid Species -- 3.3 Additional Species -- 4 Host Association of Campylobacter -- 4.1 Impact of Genomic High-Throughput Methods -- 4.2 Source Attribution in Clinical and Agricultural Setting -- 4.3 Relevance for Public Health (Applications) -- 5 Concluding Remarks -- References. , Management Strategies for Prevention of Campylobacter Infections Through the Poultry Food Chain: A European Perspective -- 1 Introduction -- 2 Management Practices and Control Options -- 2.1 Farm Level -- 2.2 Abattoir Level -- 2.3 Post-harvest Level -- 2.4 Retail and Consumer Phase -- 2.5 Management and Responsibilities -- 3 Concluding Remarks -- References -- Emission Sources of Campylobacter from Agricultural Farms, Impact on Environmental Contamination and Intervention Strategies -- 1 Introduction -- 2 Colonization of Campylobacter in Livestock -- 3 Emission Sources -- 3.1 Manure -- 3.2 Air -- 3.3 Insects and Rodents -- 3.4 Personnel, Equipment, Vehicles -- 3.5 Waterborne Emission -- 4 Tenacity of Campylobacter in the Environment -- 5 Viable but Non-culturable Form of Campylobacter in the Environment -- 6 Intervention Against Emission -- 7 Concluding Remarks -- References -- Phage Biocontrol of Campylobacter: A One Health Approach -- 1 Introduction -- 2 Campylobacter Bacteriophages in a One Health Approach -- 3 Interactions of Bacteria with Their Bacteriophages and the Development of Resistance -- 4 Phage Treatment of Campylobacter in the Literature -- 4.1 Experimental Phage Treatment of Contaminated Meat -- 4.2 Experimental Phage Treatment of Colonized Chickens -- 5 Practical Hurdles and Open Questions that Need to Be Addressed -- 6 Resistance of Campylobacter Phages -- 7 Regulatory Aspects and Safety of Campylobacter Bacteriophages -- 8 Concluding Remarks -- References -- Campylobacter Virulence Factors and Molecular Host-Pathogen Interactions -- 1 Introduction -- 2 Bacterial Virulence Factors and Epithelial Cell Responses -- 2.1 Specialized Metabolism and Enteric Life Style -- 2.2 Campylobacter Motility and Chemotaxis -- 2.3 CDT Toxin Production -- 2.4 Serine Protease HtrA and Epithelial Barrier Disruption. , 2.5 Outer Membrane Adhesins and Host Cell Binding -- 2.6 The Flagellum as a Specialized Type III Secretion System -- 2.7 Bacterial Factors and Signaling Involved in Host Cell Invasion -- 2.8 Intracellular Survival and Trafficking of Campylobacter -- 3 Bacterial Virulence Factors and Immune Cell Responses -- 3.1 Interaction with Toll-Like Receptors -- 3.2 Role of Siglec Receptors -- 3.3 Activation of the NLRP3 Inflammasome -- 4 Concluding Remarks -- References -- Diarrheal Mechanisms and the Role of Intestinal Barrier Dysfunction in Campylobacter Infections -- 1 Introduction -- 2 Pathogenetic Principles and Diarrheal Mechanisms in campylobacteriosis -- 2.1 Barrier Dysfunction, Leak Flux and Leaky Gut -- 2.2 Immune Cell Response and Barrier Function -- 3 Barrier Dysfunction in Campylobacter Infection -- 3.1 Barrier Defects by C. jejuni, C. coli, C. fetus, C. concisus and Related Bacteria -- 3.2 Protective Approaches -- 4 Concluding Remarks -- References -- Murine Models for the Investigation of Colonization Resistance and Innate Immune Responses in Campylobacter Jejuni Infections -- 1 Introduction -- 2 Factors Affecting Campylobacter Colonization and Infection -- 3 Susceptibility to Lipooligosaccharide Determines Host Specificity of Campylobacter Colonization Versus Infection -- 3.1 Chickens -- 3.2 Mice -- 3.3 Humans -- 4 Murine Infection Models in Campylobacteriosis Research -- 4.1 Germfree and Secondary Abiotic Mice -- 4.2 Human Microbiota-Associated Mice -- 4.3 Infant Mice -- 4.4 Zinc-Deficient Mice -- 4.5 SIGIRR-Deficient Mice -- 4.6 IL-10 Deficient Mice -- 5 Concluding Remarks -- References -- Natural Competence and Horizontal Gene Transfer in Campylobacter -- 1 Introduction -- 2 Mechanisms of Horizontal Gene Transfer -- 2.1 Natural Transformation and Uptake of Free DNA -- 2.2 Conjugative Gene Transfer. , 2.3 Phage Transduction and Genomic Rearrangements -- 3 Barriers to Horizontal Gene Transfer -- 3.1 CRISPR-Cas and Nucleases -- 3.2 Methylation-Dependent DNA Recognition -- 4 Impact of Gene Transfer on Campylobacter Fitness -- 4.1 Spread of Resistomes and Persistence Factors -- 4.2 Interspecies Gene Transfer -- 5 Concluding Remarks -- References -- Molecular Mechanisms of Campylobacter Biofilm Formation and Quorum Sensing -- 1 Introduction -- 2 Microbial Biofilm Formation -- 2.1 Building and Dispersion of Microbial Biofilms -- 2.2 Methods to Analyse Biofilms -- 2.3 Environmental Conditions Influencing Campylobacter jejuni Biofilm Formation -- 2.4 Genetic Background and Genes Impacting Biofilm Formation of C. jejuni -- 2.5 Control Strategies Targeting C. jejuni Biofilms -- 3 Quorum Sensing -- 3.1 Quorum Sensing Signalling Mechanisms -- 3.2 Phenotypes of C. jejuni luxS Mutants -- 3.3 Quorum Quenching -- 4 Concluding Remarks -- References -- Correction to: Fighting Campylobacter Infections -- Correction to: S. Backert (ed.), Fighting Campylobacter Infections, Current Topics in Microbiology and Immunology 431, https://doi.org/10.1007/978-3-030-65481-8.

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