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  • 2015-2019  (3)
  • 1
    Publication Date: 2015-12-29
    Description: A study of the activation of the light-induced degradation in compensated n -type Czochralski grown silicon is presented. A kinetic model is established that verifies the existence of both the fast and the slow components known from p -type and proves the quadratic dependence of the defect generation rates of both defects on the hole concentration. The model allows for the description of lifetime degradation kinetics in compensated n -type silicon under various intensities and is in accordance with the findings for p -type silicon. We found that the final concentrations of the slow defect component in compensated n -type silicon only depend on the interstitial oxygen concentration and on neither the boron concentration nor the equilibrium electron concentration n 0 . The final concentrations of the fast defect component slightly increase with increasing boron concentration. The results on n -type silicon give new insight to the origin of the BO defect and question the existing models for the defect composition.
    Print ISSN: 0021-8979
    Electronic ISSN: 1089-7550
    Topics: Physics
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  • 2
    Publication Date: 2015-01-10
    Description: Hypertension and diabetes mellitus are highly correlated, but the underlying mechanisms are only partly understood. Therefore, the aim of our study was to investigate the relationships between plasma levels of glucagon-like peptide-1, a key factor in the regulation of glucose homeostasis, and various blood pressure indices. Healthy adults aged 25 to 41 years were enrolled in a population-based study. Established cardiovascular disease, diabetes mellitus, or a body mass index 〉35 kg/m 2 were exclusion criteria. Fasting plasma glucagon-like peptide-1 levels as determined with a novel high-sensitive assay and ambulatory blood pressure data were available in 1479 participants not using antihypertensive treatment. Median age of our population was 38 years. Mean systolic and diastolic blood pressure across increasing glucagon-like peptide-1 quartiles were 120.6, 122.8, 123.2, and 124.9 mm Hg and 77.1, 78.7, 78.9, and 79.9 mm Hg, respectively. We found a linear relationship of glucagon-like peptide-1 with 24-hour ambulatory blood pressure after multivariable adjustment (β per 1 log-unit increase 2.01; 95% confidence interval, 1.02–3.00; P 〈0.0001 for systolic and 1.22; 0.47–1.97; P =0.002 for diastolic blood pressure). In separate analyses, glucagon-like peptide-1 was significantly related to both awake (β per 1 log-unit increase 2.05; 1.02–3.09; P =0.0001 for systolic and 1.15; 0.35–1.96; P =0.005 for diastolic blood pressure) and asleep blood pressure (β per 1 log-unit increase 1.34; 0.26–2.42; P =0.01 for systolic and 1.05; 0.26–1.84; P =0.009 for diastolic blood pressure). In conclusion, plasma levels of glucagon-like peptide-1 are significantly associated with both systolic and diastolic blood pressure levels.
    Keywords: Other diabetes, Epidemiology
    Print ISSN: 0194-911X
    Topics: Medicine
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  • 3
    Publication Date: 2015-05-14
    Description: BACKGROUND The aim of this study was to evaluate the relationship of cardiac troponin (cTn) levels with conventional and ambulatory blood pressure (BP) in young and healthy adults. METHODS We performed a population based cross-sectional analysis among 2,072 young and healthy adults aged 25–41 years free of cardiovascular disease and diabetes mellitus. cTnI was measured using a highly sensitive (hs) assay. The relationships of high sensitivity cardiac tropononin I (hs-cTnI) with office and 24-hour BP were assessed using multivariable regression analyses. RESULTS Median age was 37 years and 975 (47%) participants were male. hs-cTnI levels were detectable in 2,061 (99.5%) individuals. Median (interquartile range) hs-cTnI levels were 0.98 (0.71; 1.64) ng/L among men and 0.48 (0.33; 0.71) ng/L among women. Systolic BP, but not diastolic BP, gradually increased across hs-cTnI quartiles (118, 120, 121, and 122 mm Hg for conventional BP; P = 0.0002; 122, 123, 124, and 124 mm Hg for 24-hour BP, P = 0.0001). In multivariable linear regression analyses, the β estimates for systolic BP per 1-unit increase in log transformed hs-cTnI were 2.52 for conventional BP ( P = 0.0001); 2.75 for 24-hour BP ( P 〈 0.0001); 2.71 and 2.41 ( P 〈 0.0001 and P = 0.0002) for day and nighttime BP, respectively. There was a significant relationship between hs-cTnI and the Sokolow–Lyon Index (odds ratio (95% confidence interval): 2.09 (1.37; 3.18), P 〈 0.001). CONCLUSION Using a hs assay, hs-cTnI was detectable in virtually all participants of a young and healthy population. hs-cTnI was independently associated with systolic BP and left ventricular hypertrophy.
    Print ISSN: 0895-7061
    Electronic ISSN: 1879-1905
    Topics: Medicine
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