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  • 1
    In: Experimental Neurology, Elsevier BV, Vol. 250 ( 2013-12), p. 333-340
    Materialart: Online-Ressource
    ISSN: 0014-4886
    RVK:
    Sprache: Englisch
    Verlag: Elsevier BV
    Publikationsdatum: 2013
    ZDB Id: 1466932-8
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    In: Cochlear Implants International, Informa UK Limited, Vol. 15, No. 6 ( 2014-11), p. 327-332
    Materialart: Online-Ressource
    ISSN: 1467-0100 , 1754-7628
    Sprache: Englisch
    Verlag: Informa UK Limited
    Publikationsdatum: 2014
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    In: Science Progress, SAGE Publications, Vol. 104, No. 3 ( 2021-07), p. 003685042110320-
    Kurzfassung: This study aimed to evaluate the feasibility and accuracy of electromagnetic navigation at the lateral skull base in combination with flat panel volume computed tomography (fpVCT) datasets. A mastoidectomy and a posterior tympanotomy were performed on 10 samples of fresh frozen temporal bones. For registration, four self-drilling titanium screws were applied as fiducial markers. Multi-slice computed tomography (MSCT; 600 µm), conventional flat panel volume computed tomography (fpVCT; 466 µm), micro-fpVCT (197 µm) and secondary reconstructed fpVCT (100 µM) scans were performed and data were loaded into the navigation system. The resulting fiducial registration error (FRE) was analysed, and control of the navigation accuracy was performed. The registration process was very quick and reliable with the screws as fiducials. Compared to using the MSCT data, the micro-fpVCT data led to significantly lower FRE values, whereas conventional fpVCT and secondary reconstructed fpVCT data had no advantage in terms of accuracy. For all imaging modalities, there was no relevant visual deviation when targeting defined anatomical points with a navigation probe. fpVCT data are very well suited for electromagnetic navigation at the lateral skull base. The use of titanium screws as fiducial markers turned out to be ideal for comparing different imaging methods. A further evaluation of this approach by a clinical trial is required.
    Materialart: Online-Ressource
    ISSN: 0036-8504 , 2047-7163
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2021
    ZDB Id: 2483680-1
    ZDB Id: 2199376-2
    SSG: 11
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    In: Otology & Neurotology, Ovid Technologies (Wolters Kluwer Health), Vol. 42, No. 3 ( 2021-03), p. e294-e303
    Kurzfassung: Flat-panel volume computed tomography (fpVCT) and secondary reconstruction allow for more accurate measurements of two-turn length (2TL), cochlear duct length (CDL), and angular length (AL). Background: Cochlear geometry is a controversially debated topic. In the meantime, there are many different studies partly reporting highly divergent values. Our aim is to discuss the differences and to propose a radiological possibility to improve cochlear measurements using 3D-curved multiplanar reconstruction and fpVCT. Methods: Performing different image modalities and settings, we tried to find a clinically usable option that allows for a high degree of accuracy. Therefore, we tested them against reference values of high-definition micro-computed tomography. Results: Comparison of 99 μm slice thickness secondary reconstruction of fpVCT and reference showed no significant differences for 2TL and CDL ( p  ≥ 0.05). Accordingly, ICC (intraclass correlation) values were excellent (ICC ≥ 0.75; lower limit of confidence interval [CI] ≥ 0.75; Cronbach's alpha [α]  ≥ 0.9). Evaluating AL, there was a significant difference (difference: −17.27°; p  = 0.002). The lower limit of the CI of the ICC was unacceptable (ICC = 0.944; lower limit of CI = 0.248; α = 0.990). Regarding the Bland-Altman plots, there were no clinically unacceptable errors, but a systematic underestimation of AL. Conclusion: Secondary reconstruction is a suitable tool for producing reliable data that allow the accurate measurement of 2TL and CDL. The option of generating these reconstructions from raw data limits the need for higher radiation doses. Nevertheless, there is an underestimation of AL using secondary reconstructions.
    Materialart: Online-Ressource
    ISSN: 1531-7129 , 1537-4505
    Sprache: Englisch
    Verlag: Ovid Technologies (Wolters Kluwer Health)
    Publikationsdatum: 2021
    ZDB Id: 2058738-7
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Online-Ressource
    Online-Ressource
    Ovid Technologies (Wolters Kluwer Health) ; 2015
    In:  NeuroReport Vol. 26, No. 13 ( 2015-09-9), p. 797-801
    In: NeuroReport, Ovid Technologies (Wolters Kluwer Health), Vol. 26, No. 13 ( 2015-09-9), p. 797-801
    Materialart: Online-Ressource
    ISSN: 0959-4965
    Sprache: Englisch
    Verlag: Ovid Technologies (Wolters Kluwer Health)
    Publikationsdatum: 2015
    ZDB Id: 2031485-1
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
    Online-Ressource
    Online-Ressource
    Ovid Technologies (Wolters Kluwer Health) ; 2022
    In:  Otology & Neurotology Vol. 43, No. 10 ( 2022-12), p. 1176-1180
    In: Otology & Neurotology, Ovid Technologies (Wolters Kluwer Health), Vol. 43, No. 10 ( 2022-12), p. 1176-1180
    Kurzfassung: To evaluate a new methodological approach of applying anatomy-based fitting (ABF) in experienced cochlear implant (CI) users. Participants Three experienced unilateral and bilateral CI users with postlingual hearing loss. Intervention Postoperative imaging, via a high-volume Dyna computed tomography, and exact electrode measurement positions were integrated into the clinical fitting software following a new procedure, which adapted individual frequency bandwidths within the audio processor. Main Outcome Measures Speech perception in quiet and noise, clinical mapping, and self-perceived level of auditory benefit were assessed. Results For each CI user, ABF mapping provided better speech perception in quiet and in noise compared with the original clinical fitting mapping. In addition, ABF mapping was accepted in CI users despite unequal bilateral array insertion depths and lengths; however, acceptance was only established if the point of first electrode contact was less than 230 Hz. Conclusions ABF mapping increased the acceptance in CI users with longer electrode arrays and in bilateral CI users who were unsatisfied with their device experience. A larger prospective, randomized investigation is currently underway to assess longitudinal outcomes with ABF mapping.
    Materialart: Online-Ressource
    ISSN: 1537-4505 , 1531-7129
    Sprache: Englisch
    Verlag: Ovid Technologies (Wolters Kluwer Health)
    Publikationsdatum: 2022
    ZDB Id: 2058738-7
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
    Online-Ressource
    Online-Ressource
    Ovid Technologies (Wolters Kluwer Health) ; 2020
    In:  Otology & Neurotology Vol. 41, No. 6 ( 2020-07), p. 727-735
    In: Otology & Neurotology, Ovid Technologies (Wolters Kluwer Health), Vol. 41, No. 6 ( 2020-07), p. 727-735
    Kurzfassung: To implement a unified testing framework into clinical routine that can be used by adults with single-sided deafness (SSD) to assess alternative treatment options before cochlear implantation. Study Design: Retrospective data analysis. Setting: Tertiary referral center with a large CI program. Subjects and Methods: Thirty four participants underwent the new implemented testing procedure, including a test trial with contralateral routing of the signal (CROS) hearing aids and bone conduction devices (BCD) on a headband, before deciding whether to proceed with cochlear implantation. A test battery was used to assess speech in noise, binaural effects (head shadow, squelch, summation, spatial release from masking), sound localization, and quality of life. For participants that chose a CI, the same test battery was repeated during the 6 and 12 months follow-up appointments. Results: Of the 34 participants involved in the study, 11 were implanted with a CI and finished their 12 month evaluation. Sixteen participants decided to stop after the CROS/BCD trial. In the CI-recipient group, a significant head shadow effect of 5.1 to 7.1 dB was achieved with the CI. Recipients in this group received only a limited benefit with either CROS or BCD before implantation. In the non-CI-recipient group, a significant difference between the CROS and BCD, in favor for the CROS device, was found calculating the head shadow and squelch effect. Localization abilities with the CI improved significantly in the CI-recipient group, even between the 6- and 12-month follow-up appointments. In the non-CI-recipient group, localization was significantly better with the BCD during the trial period. Higher scores were obtained from the speech and spatial categories of the Speech, Spatial, and Qualities of Hearing (SSQ) questionnaire with the CI. No subjective difference could be determined in the non-CI-recipient group. Conclusion: Implementing the unified testing framework into a clinical routine was challenging but provided helpful insight into the best treatment option for each individual.
    Materialart: Online-Ressource
    ISSN: 1531-7129 , 1537-4505
    Sprache: Englisch
    Verlag: Ovid Technologies (Wolters Kluwer Health)
    Publikationsdatum: 2020
    ZDB Id: 2058738-7
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
    In: Journal of Biomedical Materials Research Part A, Wiley, Vol. 106, No. 1 ( 2018-01), p. 65-72
    Kurzfassung: Auditory implants stimulate the neurons by broad electrical fields, which leads to a low number of spectral channels. A reduction in the distance between the electrode and the neuronal structures might lead to better electrical transduction. The use of microstructured semiconductors offers a large number of contacts, which could attract neurons and stimulate them individually. To investigate the interaction between neurons and semiconductors, differentiated neuronal precursor cells were cultured on silicon wafers. Different structures were added on the wafers by electron beam lithography, and deep reactive ion etching in different depths (2 and 7 µm). Grooved surfaces guided the neurons and resulted in straight oriented axons, but neuronal outgrowth was impaired by the 7 µm grooves. Within the 7 µm structures, the neuronal cell body was totally encased and the nuclei were deformed from a round to an elliptical shape. On both square and cylindrical structures neuronal bridging could be detected in different forms, either between the tops of the structures or between the bottom and the top. Furthermore, neuronal bridges were established on the lateral part of the structures, and change in direction of neuronal growth was induced by the structure. Finally, it could be shown that neuronal growth cones were particularly attracted by the top of the cylinders, which might allow for the stimulation of neurons via this structure. In conclusion, study results indicate that structured semiconductors can modulate neuronal growth and its direction, offering a novel method for the development of new implants with improved neuronal stimulation. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 65–72, 2018.
    Materialart: Online-Ressource
    ISSN: 1549-3296 , 1552-4965
    URL: Issue
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2018
    ZDB Id: 1477192-5
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
    Online-Ressource
    Online-Ressource
    JMIR Publications Inc. ; 2021
    In:  JMIR mHealth and uHealth Vol. 9, No. 1 ( 2021-1-26), p. e19346-
    In: JMIR mHealth and uHealth, JMIR Publications Inc., Vol. 9, No. 1 ( 2021-1-26), p. e19346-
    Kurzfassung: For the classification of facial paresis, various systems of description and evaluation in the form of clinician-graded or software-based scoring systems are available. They serve the purpose of scientific and clinical assessment of the spontaneous course of the disease or monitoring therapeutic interventions. Nevertheless, none have been able to achieve universal acceptance in everyday clinical practice. Hence, a quick and precise tool for assessing the functional status of the facial nerve would be desirable. In this context, the possibilities that the TrueDepth camera of recent iPhone models offer have sparked our interest. Objective This paper describes the utilization of the iPhone’s TrueDepth camera via a specially developed app prototype for quick, objective, and reproducible quantification of facial asymmetries. Methods After conceptual and user interface design, a native app prototype for iOS was programmed that accesses and processes the data of the TrueDepth camera. Using a special algorithm, a new index for the grading of unilateral facial paresis ranging from 0% to 100% was developed. The algorithm was adapted to the well-established Stennert index by weighting the individual facial regions based on functional and cosmetic aspects. Test measurements with healthy subjects using the app were performed in order to prove the reliability of the system. Results After the development process, the app prototype had no runtime or buildtime errors and also worked under suboptimal conditions such as different measurement angles, so it met our criteria for a safe and reliable app. The newly defined index expresses the result of the measurements as a generally understandable percentage value for each half of the face. The measurements that correctly rated the facial expressions of healthy individuals as symmetrical in all cases were reproducible and showed no statistically significant intertest variability. Conclusions Based on the experience with the app prototype assessing healthy subjects, the use of the TrueDepth camera should have considerable potential for app-based grading of facial movement disorders. The app and its algorithm, which is based on theoretical considerations, should be evaluated in a prospective clinical study and correlated with common facial scores.
    Materialart: Online-Ressource
    ISSN: 2291-5222
    Sprache: Englisch
    Verlag: JMIR Publications Inc.
    Publikationsdatum: 2021
    ZDB Id: 2719220-9
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
    Online-Ressource
    Online-Ressource
    Springer Science and Business Media LLC ; 2019
    In:  European Archives of Oto-Rhino-Laryngology Vol. 276, No. 12 ( 2019-12), p. 3317-3325
    In: European Archives of Oto-Rhino-Laryngology, Springer Science and Business Media LLC, Vol. 276, No. 12 ( 2019-12), p. 3317-3325
    Materialart: Online-Ressource
    ISSN: 0937-4477 , 1434-4726
    RVK:
    Sprache: Englisch
    Verlag: Springer Science and Business Media LLC
    Publikationsdatum: 2019
    ZDB Id: 1459042-6
    Standort Signatur Einschränkungen Verfügbarkeit
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