In:
FEBS Letters, Wiley, Vol. 185, No. 1 ( 1985-06-03), p. 9-13
Kurzfassung:
Previous studies demonstrated that human circulating monocytes can proliferate in vitro when incubated with lectin‐induced factor(s) from lymphocytes [(1985) Biochem. Biophys. Res. Commun., in press]. This study shows that human monocytes were induced to proliferate when incubated with 1α,25‐dihydroxy vitamin D 3 (calcitriol) at physiological concentrations. The optimal dose was about 10 nM. Proliferative activity was examined both by measuring the [su3H]thymidine incorporation and by counting cell nuclei. Among other derivatives of vitamin D 3 , 1α,24 R ‐dihydroxyvitamin D 3 and 1α,24 R ,25‐trihydroxyvitamin D 3 stimulated mitotic activity of monocytes. Addition of both calcitriol and lectin‐stimulated lymphocyte‐conditioned medium to the monocyte culture had an additional effect on the mitotic activity of monocytes.
Materialart:
Online-Ressource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/0014-5793(85)80730-4
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
1985
ZDB Id:
1460391-3
SSG:
12
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