In:
PLOS ONE, Public Library of Science (PLoS), Vol. 15, No. 12 ( 2020-12-16), p. e0243759-
Abstract:
Following a successful renal transplantation circulating markers of inflammation may remain elevated, and systemic inflammation is associated with worse clinical outcome in renal transplant recipients (RTRs). Vitamin D-receptor (VDR) activation is postulated to modulate inflammation and endothelial function. We aimed to explore if a synthetic vitamin D, paricalcitol, could influence systemic inflammation and immune activation in RTRs. Newly transplanted RTRs were included in an open-label randomized controlled trial on the effect of paricalcitol on top of standard care over the first post-transplant year. Fourteen pre-defined circulating biomarkers reflecting leukocyte activation, endothelial activation, fibrosis and general inflammatory burden were analyzed in 74 RTRs at 8 weeks (baseline) and 1 year post-engraftment. Mean changes in plasma biomarker concentrations were compared by t -test. The expression of genes coding for the same biomarkers were investigated in 1-year surveillance graft biopsies (n = 60). In patients treated with paricalcitol circulating osteoprotegerin levels increased by 0.19 ng/ml, compared with a 0.05 ng/ml increase in controls (p = 0.030). In graft tissue, a 21% higher median gene expression level of TNFRSF11B coding for osteoprotegerin was found in paricalcitol-treated patients compared with controls (p = 0.026). Paricalcitol treatment did not significantly affect the blood- or tissue levels of any other investigated inflammatory marker. In RTRs, paricalcitol treatment might increase both circulating and tissue levels of osteoprotegerin, a modulator of calcification, but potential anti-inflammatory treatment effects in RTRs are likely very modest. [NCT01694160 (2012/107D)]; [ www.clinicaltrials.gov ].
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0243759
DOI:
10.1371/journal.pone.0243759.g001
DOI:
10.1371/journal.pone.0243759.g002
DOI:
10.1371/journal.pone.0243759.t001
DOI:
10.1371/journal.pone.0243759.t002
DOI:
10.1371/journal.pone.0243759.s001
DOI:
10.1371/journal.pone.0243759.s002
DOI:
10.1371/journal.pone.0243759.s003
DOI:
10.1371/journal.pone.0243759.s004
DOI:
10.1371/journal.pone.0243759.s005
DOI:
10.1371/journal.pone.0243759.s006
DOI:
10.1371/journal.pone.0243759.s007
DOI:
10.1371/journal.pone.0243759.r001
DOI:
10.1371/journal.pone.0243759.r002
DOI:
10.1371/journal.pone.0243759.r003
DOI:
10.1371/journal.pone.0243759.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2020
detail.hit.zdb_id:
2267670-3
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