In:
Synthesis, Georg Thieme Verlag KG, Vol. 55, No. 12 ( 2023-06), p. 1940-1948
Kurzfassung:
A nine-step synthetic route to access the tricyclic core of FR901483 is reported, featuring a key aza-Wacker cyclization step to construct an α-tertiary amine (ATA) in the bridged structure. The aza-Wacker protocol can tolerate both exocyclic and endocyclic double bonds, providing viable access to various bridged bicyclic rings bearing an ATA (e.g., 6-azabicyclo[3.2.1]octane, 7-azabicyclo[3.3.1] nonane, and 7-azabicyclo[4.2.1]nonane) in good to excellent yields. The synthetic studies presented herein enable structural derivatization of FR901483 to further exploit its compelling biological activities.
Materialart:
Online-Ressource
ISSN:
0039-7881
,
1437-210X
Sprache:
Englisch
Verlag:
Georg Thieme Verlag KG
Publikationsdatum:
2023
ZDB Id:
204080-3
ZDB Id:
2033062-5
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