In:
Journal of Bone and Mineral Research, Wiley, Vol. 12, No. 8 ( 1997-08), p. 1272-1279
Abstract:
The present study was performed to investigate the role of insulin‐like growth factor I (IGF‐I), IGF‐binding protein‐2 (IGFBP‐2), and IGFBP‐3 in age‐dependent bone loss in postmenopausal Japanese women. One hundred and sixty‐five Japanese women aged 43–88 years (mean age, 62) were enrolled in the cross‐sectional study. Bone mineral density (BMD) was measured at the lumbar spine, femoral neck, and midradius by dual‐energy X‐ray absorptiometry or single‐photon absorptiometry. Serum levels of IGF‐I, IGFBP‐2, and IGFBP‐3 were measured by radioimmunoassay. BMD at all sites as well as serum levels of IGF‐I and IGFBP‐3 declined with age, while the serum IGFBP‐2 level increased with age. Serum IGFBP‐3 and −2 levels were positively and negatively correlated with the serum IGF‐I level, respectively. Serum IGF‐I and IGFBP‐3 levels showed positive correlationship with BMD at any site, particularly at the midradius, while the serum IGFBP‐2 level showed negative correlation with BMD. Multiple regression analyses showed age‐independent positive correlation between the serum IGF‐I level and BMD at all sites as well as age‐independent positive correlation between the serum IGFBP‐3 level and midradius BMD. The relationship between susceptibility to osteoporotic spinal fracture and serum IGF‐I, IGFBP‐3, or −2 levels was examined by decade to exclude the influence of aging. Serum levels of IGF‐I and IGFBP‐3 were significantly lower in subjects with spinal fractures than those without fractures at any decade. No significant difference of serum IGFBP‐2 level was observed between subjects with and without fractures. The present findings suggest that IGF‐I and IGFBP‐3 are important to maintaining bone mass quantitatively as well as qualitatively, and that the determination of serum IGF‐I and IGFBP‐3 levels could be clinically useful to predict the severity of osteoporosis, particularly the risk of bone fracture associated with osteoporosis.
Type of Medium:
Online Resource
ISSN:
0884-0431
,
1523-4681
DOI:
10.1359/jbmr.1997.12.8.1272
Language:
English
Publisher:
Wiley
Publication Date:
1997
detail.hit.zdb_id:
2008867-X
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