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  • 1
    In: Infection and Drug Resistance, Informa UK Limited, Vol. Volume 14 ( 2021-05), p. 1931-1939
    Type of Medium: Online Resource
    ISSN: 1178-6973
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2494856-1
    SSG: 15,3
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  • 2
    Online Resource
    Online Resource
    Faculty of Rehabilitation and Allied Health Sciences, Riphah International University ; 2023
    In:  Journal Riphah College of Rehabilitation Sciences Vol. 11, No. 01 ( 2023-03-10), p. 23-27
    In: Journal Riphah College of Rehabilitation Sciences, Faculty of Rehabilitation and Allied Health Sciences, Riphah International University, Vol. 11, No. 01 ( 2023-03-10), p. 23-27
    Type of Medium: Online Resource
    ISSN: 2226-9215 , 2410-888X
    Language: Unknown
    Publisher: Faculty of Rehabilitation and Allied Health Sciences, Riphah International University
    Publication Date: 2023
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  • 3
    In: Antibiotics, MDPI AG, Vol. 10, No. 4 ( 2021-04-20), p. 467-
    Abstract: Plasmid-mediated colistin resistance (Col-R) conferred by mcr genes endangers the last therapeutic option for multifarious β-lactamase-producing bacteria. The current study aimed to explore the mcr gene molecular epidemiology in extensively drug-resistant (XDR) bacteria. Col-R gram-negative bacterial strains were screened using a minimum inhibitory concentration (MIC) breakpoint ≥4 µg/mL. Resistant isolates were examined for mcr variants, extended-spectrum β-lactamase, AmpC, and carbapenemase genes using polymerase chain reaction (PCR). The MIC breakpoints for mcr-positive strains were determined using broth microdilution and E-test strips. Overall, 19/718 (2.6%) gram-negative rods (GNRs) harboring mcr were identified, particularly in pus (p = 0.01) and tracheal secretions (p = 0.03). Molecular epidemiology data confirmed 18/19 (95%) mcr-1 and 1/19 (5%) mcr-2 genes. Integron detection revealed 15/17 (88%) Int-1 and 2/17 (12%) Int-2. Common co-expressing drug-resistant β-lactamase genes included 8/16 (50%) blaCTM-1, 3/16 (19%) blaCTM-15, 3/3 (100%) blaCMY-2, 2/8 (25%) blaNDM-1, and 2/8 (25%) blaNDM-5. The MIC50 and MIC90 values (µg/mL) were as follows: Escherichia coli, 12 and 24; Klebsiella pneumoniae, 12 and 32; Acinetobacter baumannii, 8 and 12; and Pseudomonas aeruginosa, 32 and 64, respectively. Treatment of XDR strains has become challenging owing to the co-expression of mcr-1, mcr-2, multifarious β-lactamase genes, and integrons.
    Type of Medium: Online Resource
    ISSN: 2079-6382
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2681345-2
    SSG: 15,3
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  • 4
    Online Resource
    Online Resource
    Institute of Electrical and Electronics Engineers (IEEE) ; 2022
    In:  IEEE Access Vol. 10 ( 2022), p. 19333-19347
    In: IEEE Access, Institute of Electrical and Electronics Engineers (IEEE), Vol. 10 ( 2022), p. 19333-19347
    Type of Medium: Online Resource
    ISSN: 2169-3536
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2022
    detail.hit.zdb_id: 2687964-5
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  • 5
    In: Foods, MDPI AG, Vol. 11, No. 18 ( 2022-09-06), p. 2728-
    Abstract: Foodborne pathogens have acquired the ability to produce biofilms to survive in hostile environments. This study evaluated biofilm formation, antimicrobial resistance (AMR), and heavy metal tolerance of bacteria isolated from dairy and non-dairy food products. We aseptically collected and processed 200 dairy and non-dairy food specimens in peptone broth, incubated them overnight at 37 °C, and sub-cultured them on various culture media. Bacterial growth was identified with biochemical tests and API 20E and 20NE strips. The AMR of the isolates was observed against different antibacterial drug classes. Biofilm formation was detected with the crystal violet tube method. Heavy metal salts were used at concentrations of 250–1500 µg/100 mL to observe heavy metal tolerance. We isolated 180 (50.4%) bacteria from dairy and 177 (49.6%) from non-dairy food samples. The average colony-forming unit (CFU) count for dairy and non-dairy samples was 2.9 ± 0.9 log CFU/mL and 5.1 ± 0.3 log CFU/mL, respectively. Corynebacterium kutscheri (n = 74), lactobacilli (n = 73), and Staphylococcus aureus (n = 56) were the predominant Gram-positive and Shigella (n = 10) the predominant Gram-negative bacteria isolated. The correlation between biofilm formation and AMR was significant (p 〈 0.05) for most cephalosporins, aminoglycosides, and fluoroquinolones. Heavy metal tolerance tended to be higher in biofilm producers at different metal concentrations. The pathogens isolated from dairy and non-dairy food showed a high burden of AMR, high propensity for biofilm formation, and heavy metal tolerance, and pose an imminent threat to public health.
    Type of Medium: Online Resource
    ISSN: 2304-8158
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2704223-6
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  • 6
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2019
    In:  Cluster Computing Vol. 22, No. S1 ( 2019-1), p. 1703-1716
    In: Cluster Computing, Springer Science and Business Media LLC, Vol. 22, No. S1 ( 2019-1), p. 1703-1716
    Type of Medium: Online Resource
    ISSN: 1386-7857 , 1573-7543
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2019
    detail.hit.zdb_id: 2012757-1
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  • 7
    In: Antibiotics, MDPI AG, Vol. 11, No. 9 ( 2022-08-30), p. 1168-
    Abstract: The emergence of carbapenem-resistant Acinetobacter calcoaceticus-baumannii complex (CRACB) in clinical environments is a significant global concern. These critical pathogens have shown resistance to a broad spectrum of antibacterial drugs, including carbapenems, mostly due to the acquisition of various β-lactamase genes. Clinical samples (n = 1985) were collected aseptically from multiple sources and grown on blood and MacConkey agar. Isolates and antimicrobial susceptibility were confirmed with the VITEK-2 system. The modified Hodge test confirmed the CRACB phenotype, and specific PCR primers were used for the molecular identification of blaOXA and blaNDM genes. Of the 1985 samples, 1250 (62.9%) were culture-positive and 200 (43.9%) were CRACB isolates. Of these isolates, 35.4% were recovered from pus samples and 23.5% from tracheal secretions obtained from patients in intensive care units (49.3%) and medical wards (20.2%). An antibiogram indicated that 100% of the CRACB isolates were resistant to β-lactam antibiotics and β-lactam inhibitors, 86.5% to ciprofloxacin, and 83.5% to amikacin, while the most effective antibiotics were tigecycline and colistin. The CRACB isolates displayed resistance to eight different AWaRe classes of antibiotics. All isolates exhibited the blaOXA-51 gene, while blaOXA-23 was present in 94.5%, blaVIM in 37%, and blaNDM in 14% of the isolates. The blaOXA-51, blaOXA-23, and blaOXA-24 genes co-existed in 13 (6.5%) isolates. CRACB isolates with co-existing blaOXA-23, blaOXA-24, blaNDM, blaOXA-51 and blaVIM genes were highly prevalent in clinical samples from Pakistan. CRACB strains were highly critical pathogens and presented resistance to virtually all antibacterial drugs, except tigecycline and colistin.
    Type of Medium: Online Resource
    ISSN: 2079-6382
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2681345-2
    SSG: 15,3
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  • 8
    Online Resource
    Online Resource
    Hindawi Limited ; 2020
    In:  Shock and Vibration Vol. 2020 ( 2020-07-07), p. 1-18
    In: Shock and Vibration, Hindawi Limited, Vol. 2020 ( 2020-07-07), p. 1-18
    Abstract: This paper presents experimental and numerical studies carried out on two-story reinforced concrete (RC) frames having weaker beam-column joints, which were retrofitted with reinforced concrete haunches to avoid joint panel damage under seismic actions. The design philosophy of the retrofit solution is to allow beam-column members to deform inelastically and dissipate seismic energy. Shake table tests were performed on three 1 : 3 reduced scale two-story RC frame models, including one model incorporating construction deficiencies common in developing countries, which was retrofitted with two retrofit schemes using RC haunches. The focus of the experimental study was to understand the seismic behaviour of both as-built and retrofitted models and obtain the seismic response properties, i.e., lateral force-displacement capacity curves and time histories of model response displacement. The derived capacity curves were used to quantify overstrength and ductility factors of both as-built and retrofitted frames. Finite element- (FE-) based software SeismoStruct was used to develop representative numerical models, which were calibrated with the experimental data in simulating the time history response of structure roof displacement and in predicting peak roof-displacement and peak base shear force. Moreover, the FE-based numerical models were subjected to a suite of spectrum natural accelerograms, linearly scaled to multiple intensity levels for performing incremental dynamic analysis. Lateral force-displacement capacity and response curves were developed, which were analyzed to calculate the structure ductility and overstrength factors. The structure R factor is the product of ductility and overstrength factors, which exhibited substantial increase due to the proposed retrofitting technique. A case study was presented for the seismic performance assessment of RC frames with/without RC haunches in various seismic zones using the static force procedure given in seismic code and using response modification factor quantified in the present research.
    Type of Medium: Online Resource
    ISSN: 1070-9622 , 1875-9203
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2070162-7
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  • 9
    In: Journal of Tourism Futures, Emerald, ( 2022-07-07)
    Abstract: The purpose of this study is to examine the drivers and barriers of travel behavior associated with tourist behavior during/post-COVID-19 pandemic to provide a knowledge base as well as an agenda for future research. Design/methodology/approach The authors utilized the Systematic Literature Review (SLR) technique for searching the articles published in Web of Science (WOS) and Scopus , to identify the main drivers and barriers affecting the tourist behavior during/post-COVID-19 pandemic. Eventually, 47 articles were chosen for the final analysis. Findings The findings are reported in three sections, (1) quantitative research profile, (2) qualitative synthesis and (3) future agenda. This study addresses the nuanced questions regarding the significant change in tourist travel behavior, emotional dynamics and a detailed understanding of mechanisms, such as which drivers and barriers affect tourist behavior in a particular destination. Drivers and barriers to tourist travel behavior were characterized in personal-related, destination-related, and health-related factors. Moreover, this study provides thought-provoking ideas in theory, policy and practice in the field of tourism and hospitality. Research limitations/implications This study has three limitations, as follows. First, the authors searched only two databases, Scopus and W eb of S cience , due to which the authors might be missing some related studies existing on the other databases. Although these databases provide an extensive range of academic literature, further studies could extend the data collection from the other databases (e.g. via Taylor & Francis ). However, our systematic literature review (SLR) coverage is quite extensive, since journals are listed on these three main databases. Second, the authors followed a main study search protocol based on the synonyms and related keywords, however, some of the studies that may be related to the tourist behavior towards the destination are missing on account of the lack of our keywords in there, title, author, keyword and abstract. Furthermore, future research could endeavor to add other keywords to expand the results of studies. Third, although the accurate analysis was conducted to reduce subjectivity in identifying themes for drivers and barriers of tourist behavior, future studies on categorization could work to ensure that other sub-themes categorize. Practical implications The recent study has some key practical implications. First, this study is valuable for all the stakeholders in a unique way, including destination managers, academicians and policymakers, because it provides insight into barriers and drivers that influence the development of tourist behavior towards the destination. Second, the current study also offers practical implications for people involved in tourism service industries including governments and private businesses. Policymakers and other leaders are increasingly interested in harnessing the economic potential of tourism. Therefore, identifying the barrier which is inhibiting the tourist traffic towards the destination is beneficial to understand and effectively develop strategies to minimize the effect of such factors. Moreover, drivers and barriers of tourist behavior towards the destination in the COVID-19 pandemic situation towards the destination may help to create a framework for the development of destinations according to the current vulnerable situation. Third, current findings suggest that tourism marketers understand the drivers and barrier constructs found in this study and tailor their marketing strategies for attracting existing and new tourists. For instance, marketers should understand the drivers and barriers of tourist behavior for effective strategy development to increase the positive effect of drivers and to reduce the negative effect of barriers. Originality/value This is the first systematic literature review on the impact of drivers and barriers of tourist travel behavior. This paper analyses the methods and approaches that have been used in the previous literature to examine the drivers and barriers of tourist travel behavior. The paper ends with the research implication and limitations of the studies.
    Type of Medium: Online Resource
    ISSN: 2055-5911
    Language: English
    Publisher: Emerald
    Publication Date: 2022
    detail.hit.zdb_id: 2825757-1
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  • 10
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2019
    In:  Bulletin of Earthquake Engineering Vol. 17, No. 7 ( 2019-7), p. 3895-3932
    In: Bulletin of Earthquake Engineering, Springer Science and Business Media LLC, Vol. 17, No. 7 ( 2019-7), p. 3895-3932
    Type of Medium: Online Resource
    ISSN: 1570-761X , 1573-1456
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2019
    detail.hit.zdb_id: 2098452-2
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