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  • Online-Ressource  (3)
  • S. Karger AG  (3)
  • 1
    In: Cytogenetic and Genome Research, S. Karger AG, Vol. 146, No. 4 ( 2015), p. 296-305
    Kurzfassung: 〈 i 〉 Neacomys 〈 /i 〉 (Sigmodontinae) comprises 8 species mainly found in the Amazonian region. We describe 5 new karyotypes from Brazilian Amazonia: 2 cytotypes for 〈 i 〉 N. paracou 〈 /i 〉 (2n = 56/FNa = 62-66), 1 for 〈 i 〉 N. dubosti 〈 /i 〉 (2n = 64/FNa = 68), and 2 for 〈 i 〉 Neacomys 〈 /i 〉 sp. (2n = 58/FNa = 64-70), with differences in the 18S rDNA. Telomeric probes did not show ITS. We provide a phylogeny using 〈 i 〉 Cyt 〈 /i 〉 b, and the analysis suggests that 2n = 56 with a high FNa is ancestral for the genus, as found in 〈 i 〉 N. paracou 〈 /i 〉 , being retained by the ancestral forms of the other species, with an increase in 2n occurring independently in 〈 i 〉 N. spinosus 〈 /i 〉 and 〈 i 〉 N. dubosti 〈 /i 〉 . Alternatively, an increase in 2n may have occurred in the ancestral taxon of the other species, followed by independent 2n-reduction events in 〈 i 〉 Neacomys 〈 /i 〉 sp. and in the ancestral species of 〈 i 〉 N. tenuipes 〈 /i 〉 , 〈 i 〉 N. guianae 〈 /i 〉 , 〈 i 〉 N. musseri 〈 /i 〉 , and 〈 i 〉 N. minutus 〈 /i 〉 . Finally, a drastic reduction event in the diploid number occurred in the ancestral species of 〈 i 〉 N. musseri 〈 /i 〉 and 〈 i 〉 N. minutus 〈 /i 〉 which exhibit the lowest 2n of the genus. The karyotypic variations found in both intra- and interspecific samples, associated with the molecular phylogeny, suggest a chromosomal evolution with amplification/deletion of constitutive heterochromatin and rearrangements including fusions, fissions, and pericentric inversions.
    Materialart: Online-Ressource
    ISSN: 1424-8581 , 1424-859X
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2015
    ZDB Id: 2061918-2
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Online-Ressource
    Online-Ressource
    S. Karger AG ; 2002
    In:  Fetal Diagnosis and Therapy Vol. 17, No. 6 ( 2002), p. 372-376
    In: Fetal Diagnosis and Therapy, S. Karger AG, Vol. 17, No. 6 ( 2002), p. 372-376
    Kurzfassung: 〈 i 〉 Objective: 〈 /i 〉 To evaluate the fetal survival rate using a modified technique to surgically create a ‘myelomeningocele-like’ defect in a rabbit model. 〈 i 〉 Methods: 〈 /i 〉 Six white New Zealand rabbits had a spinal defect created in their fetuses at 23 days of gestation. At 30 days of gestation, the fetuses were harvested for anatomo-pathologic evaluation. 〈 i 〉 Results: 〈 /i 〉 The defect was created in 19 fetuses and an attempt to correct it was made in 15 cases (group I), and 4 fetuses where left without correction (group II). At 30 days, a ‘myelomeningocele-like’ defect was present in all surviving fetuses. The total survival rate was 73.68% (14/19); 11 fetus survived in group I and 3 in group II. 〈 i 〉 Conclusion: 〈 /i 〉 The technical modifications, including fetal positioning and exposure of its back prior to the incision of the lamina, associated with a different technique for myometrium closure, offer an alternative and probably safer method to surgically create a spinal defect in the fetal rabbit.
    Materialart: Online-Ressource
    ISSN: 1015-3837 , 1421-9964
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2002
    ZDB Id: 1482292-1
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    In: Fetal Diagnosis and Therapy, S. Karger AG, Vol. 18, No. 3 ( 2003), p. 201-206
    Kurzfassung: 〈 i 〉 Objective: 〈 /i 〉 To study the correction of a ‘myelomeningocele-like’ defect in fetal rabbits. 〈 i 〉 Methods: 〈 /i 〉 Twelve pregnant rabbits had a spinal defect surgically created in 40 of their fetuses at 23 days of gestation. Immediate repair was performed in 30 fetuses (group I), and 10 remained uncorrected (group II). After 30 days, the fetuses were harvested and the anatomopathological aspects where compared using Fisher’s exact test. 〈 i 〉 Results: 〈 /i 〉 Three different techniques to apply a cellulose graft were used for correction in 8 (technique A), 7 (technique B), and 15 animals (technique C), but only one (technique C) was successful. The survival rate at 30 days was 66.7% (10/15) in group I and 80% (8/10) in group II. A ‘myelomeningocele-like’ defect was present in all fetuses in group II, while in group I the defect was successfully repaired in 80% of the surviving fetuses (p 〈 0.01). 〈 i 〉 Conclusion: 〈 /i 〉 The surgically created spinal defect was successfully repaired, and also the fetal rabbit could be established as a model for the study of intrauterine correction of a myelomeningocele-like defect.
    Materialart: Online-Ressource
    ISSN: 1015-3837 , 1421-9964
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2003
    ZDB Id: 1482292-1
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
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