Note: Beitr. teilw. deutsch, teilw. englisch

Note: Beitr. teilw. dt., teilw. engl

Note: Text dt. und engl. , Text dt. und engl.

Note: Intro -- Status and Prospects of Astronomy in Germany 2003-2016 Memorandum -- Contents -- Editorial committee -- Translation preface -- Preface to the original memorandum -- Summary -- 1 Astronomy yesterday, today and tomorrow -- 1.1 The history of the universe -- 1.2 The life cycle of stars and the matter cycle -- 1.3 New windows into space -- 2 The scientific issues -- 2.1 The universe - its origin, evolution and large-scale structure -- 2.1.1 The big bang and cosmic background radiation -- 2.1.2 The cosmic distance scale -- 2.1.3 Cosmological evolution -- 2.1.4 The large-scale structure of the universe -- 2.1.5 Galaxy clusters as cosmic laboratories -- 2.1.6 Ultra-high-energy gamma-ray astronomy -- 2.1.7 Astroparticle physics -- 2.1.8 New properties of neutrinos -- 2.1.9 Gravitational wave astronomy -- 2.2 Galaxies and massive black holes -- 2.2.1 Origin and evolution of galaxies -- 2.2.2 Structure of galaxies -- 2.2.3 Massive black holes -- 2.2.4 Active galactic nuclei -- 2.3 The matter cycle and stellar evolution -- 2.3.1 The interstellar medium -- 2.3.2 Cosmic rays -- 2.3.3 The nearest star: the sun -- 2.3.4 The stars -- 2.3.5 Stars as chemical factories and the engines of the matter cycle -- 2.3.6 The final stages of stellar evolution -- 2.4 Stellar and planetary formation: protostars, circumstellar disks and extrasolar planetary systems -- 2.4.1 Star formation as a fundamental cosmological process -- 2.4.2 Formation of low-mass stars: from prestellar core to dust disk -- 2.4.3 Massive stars, stellar clusters and initial mass distribution -- 2.4.4 Extrasolar planets -- 3 The next fifteen years: observatories and instruments -- 3.1 Access to telescopes and involvement in large international projects -- 3.2 Safeguarding competitiveness -- 3.3 Strengthening national innovation and initiative -- 3.4 Other planned space and balloon missions. , 3.5 New initiatives: astroparticles and gravitational wave research -- 3.6 The next decade's projects -- 3.7 The future role of existing establishments -- 3.7.1 Institute for Radio Astronomy in the Millimetre Range (IRAM) -- 3.7.2 The Effelsberg radio telescope -- 3.7.3 Calar Alto observatory -- 3.7.4 Solar telescopes -- 4 Astronomical research structures -- 4.1 Historical development -- 4.2 The current situation -- 4.3 Research institutes -- 4.4 Research funding instruments -- 4.5 Training -- 4.6 Astronomy and the public -- 5 Recommendations -- 5.1 Some fundamental aspects -- 5.2 Instruments and projects -- 5.3 Large projects -- 5.4 Medium-sized projects -- 5.5 Small projects -- 5.6 Organisational instruments -- 5.7 Interaction and cooperation -- 5.8 Securing and reinforcing funding instruments -- 6 Annex -- Member institutes of the German Council of Observatories -- Glossary/Acronyms -- Telescopes, instruments, experiments.

Note: Intro -- Funding Ranking 2006 Institutions - Regions - Networks DFG Awards and Other Basic Data on Publicly Funded Research -- Contents -- Foreword -- 1. Introduction -- 2. Funding-Based Research Indicators - Basis and Background -- 2.1 Introduction -- 2.2 Methodological Aspects -- 2.2.1 Report Focuses -- 2.2.2 Subject-related and Thematic Classification -- 2.2.3 Institutional Classification of Data -- 2.3 Funding-based Research Indicators -- 2.3.1 Basic Data -- 2.3.2 Third-Party Funding Indicators -- 2.3.3 Scientific Expertise and Top-level Researchers -- 2.3.4 International Appeal -- 2.3.5 Research-related Cooperation Activities and Networks -- 2.4 Summary -- 3. Research Profiles of Higher Education Institutions and Regions -- 3.1 Introduction -- 3.2 The 40 HEIs with the Highest DFG Funding -- 3.3 The Development of Ranking Group Allocations Over Time -- 3.4 The Funding and Research Profiles of HEIs -- 3.4.1 Thematic Profiles of HEIs, Based on DFG Awards -- 3.4.2 Thematic Profile of HEIs, Based on Direct R& -- D Funding by the German Government -- 3.4.3 Thematic Profiles of HEIs, Based on R& -- D Funding in the Sixth EU Framework Programme -- 3.5 Regional Research Profiles -- 3.6 Conclusions -- 4. Indicator Comparison at the Level of Research and Funding Area -- 4.1 Indicator Comparison for the Humanities and Social Sciences -- 4.1.1 The Humanities -- 4.1.2 Social and Behavioural Sciences -- 4.2 Comparison of Indicators in the Life Sciences -- 4.2.1 Biology -- 4.2.2 Medicine -- 4.2.3 Veterinary Medicine, Agriculture and Forestry -- 4.3 Indicator Comparison for the Natural Sciences -- 4.3.1 Chemistry -- 4.3.2 Physics -- 4.3.3 Mathematics -- 4.3.4 Geosciences -- 4.4 Comparison of Indicators for the Engineering Sciences -- 4.4.1 Mechanical and Industrial Engineering -- 4.4.2 Thermal and Process Engineering. , 4.4.3 Material Science and Engineering -- 4.4.4 Computer Science, Electrical and System Engineering -- 4.4.5 Construction Engineering and Architecture -- 4.5 Funding by the German Government, the EU and the AiF in Selected Fields of Research -- 5. Overview -- 5.1 Indicators Used and Report Focuses -- 5.2 Indicator Comparison at the Institutional Level -- 5.3 Summary of the General Findings -- 5.4 Conclusions and Outlook -- 6. Bibliography and Information Sources -- 7. Appendix -- Tables -- Table 2-1 -- Table 2-2 -- Table 2-3 -- Table 2-4 -- Table 2-5 -- Table 2-6 -- Table 2-7 -- Table 2-8 -- Table 2-9 -- Table 2-10 -- Table 2-11 -- Table 3-1 -- Table 3-2 -- Table 4-1 -- Table 4-2 -- Table 4-3 -- Table 4-4 -- Table 4-5 -- Table 4-6 -- Table 4-7 -- Table 4-8 -- Table 4-9 -- Table 4-10 -- Table 4-11 -- Table 4-12 -- Table 4-13 -- Table 4-14 -- Table 4-15 -- Table 4-16 -- Table 4-17 -- Table 4-18 -- Table 4-19 -- Table 4-20 -- Table 5-1 -- Table 5-2 -- Figures -- Figure 2-1 -- Figure 2-2 -- Figure 2-3 -- Figure 3-1 -- Figure 3-2 -- Figure 3-3 -- Figure 3-4 -- Figure 3-5 -- Figure 3-6 -- Figure 4-1 -- Figure 4-2 -- Figure 4-3 -- Figure 4-4 -- Tables in the appendix -- Table A-1 -- Table A-2 -- Table A-3 -- Table A-4 -- Table A-5 -- Table A-6 -- Table A-7 -- Table A-8 -- Table A-9 -- Table A-10 -- Table A-11 -- Table A-12 -- Table A-13 -- Table A-14 -- Table A-15 -- Table A-16 -- Table A-17 -- Table A-18 -- Table A-19 -- Table A-20 -- Table A-21 -- Table A-22 -- Table A-23 -- Table A-24 -- Table A-25.

Note: Intro -- Risk Assessment of Phytochemicals in Food: Novel Approaches -- Inhalt /Contents -- Vorwort -- Preface -- 1 Bericht und Schlussfolgerungen -- 1.1 Einleitung -- 1.2 Methodenübergreifende Aspekte -- 1.3 Methoden -- 1.4 Schlussfolgerungen und Empfehlungen -- 1.5 Fazit -- 2 Report and Conclusions -- 2.1 Preface -- 2.2 Transdisciplinary Aspects -- 2.3 Methodologies -- 2.4 Conclusions and Recommendations -- 2.5 Concluding Remarks -- 3 Contributions -- 3.1 Vision on Toxicity Testing in the 21st Century: Reflections on a Strategy Document of the US National Research Council -- 3.2 Safety Assessment of Botanicals and Botanical Preparations Used as Ingredients in Food Supplements: Testing an European Food Safety Authority-Tiered Approach -- 3.3 In Silico Toxicology Screening of the Rodent Carcinogenic Potential of Phytochemicals Using Quantitative Structure-Activity Relationship Analysis -- 3.4 Testing Computational Toxicology Models with Phytochemicals -- 3.5 In Silico Models to Establish Level of Safety Concern in Absence of Sufficient toxicological Data -- 3.6 In Silico Methods for Physiologically Based Biokinetic (PBBK) Models Describing Bioactivation and Detoxification of Coumarin and Estragole: Implications for Risk Assessment -- 3.7 In Vitro Models for Carcinogenicity Testing - Reality or Fantasy? -- 3.8 Carcinogen Specific Expression Profiling: Prediction of Carcinogenic Potential? -- 3.9 Safety and Biological Efficacy Testing of Phytochemicals: An Industry Approach -- 3.10 Metabolite Profiling in Rat Plasma as a Potential New Tool for the Assessment of Chemically Induced Toxicity -- 3.11 Profiling Techniques in Nutrition and Food Research -- 3.12 The Complex Links between Dietary Phytochemicals and Human Health Deciphered by Metabolomics. , 3.13 Anti-Oxidative and Antigenotoxic Properties of Vegetables and Dietary Phytochemicals: The Value of Genomics Biomarkers in Molecular Epidemiology -- 3.14 The Japanese Toxicogenomics Project: Application of Toxicogenomics - Utilizing Toxicogenomics into Drug Safety Screening -- 3.15 Toxicology and Risk Assessment of Coumarin: Focus on Human Data -- 3.16 Risk from Furocoumarins in Food? An Exposure Assessment -- 3.17 Transcriptome Analysis in Benefit-Risk Assessment of Micronutrients and Bioactive Food Components -- 3.18 Colorectal and Prostate Cancer: The Role of Candidate Genes in Nutritional Pathways -- 3.19 Glucosinolates: DNA Adduct Formation In Vivo and Mutagenicity In Vitro -- 3.20 Defence Mechanisms against Toxic Phytochemicals in the Diet of Domestic Animals -- 4 Posters -- 4.1 Coumarin Risk Assessment: Lessons from Human Data -- 4.2 Coffee and Coffee Compounds are Effective Antioxidants in Human Cells and In Vivo -- 4.3 Studying Absorption, Distribution, Metabolism, and Excretion of a Complex Extract -- 4.4 Polyphenolic Apple Extracts and their Constituents Modulate DNA Strand Breaks and Oxidation Damage in Human Colon Carcinoma Cells -- 4.5 Comparative Evaluation of Experimental Data on α-Amylase Inhibition by Flavonoids Using Molecular Modelling -- 4.6 Potential Risk of Furan in Foods -- 4.7 Comparative Study on the Toxicity of Alternariol and Alternariol Monomethyl Ether in Human Tumour Cells of Different Origin -- 4.8 A Role for Resveratrol and Curcumine in Sensitization of Glioblastoma Cells to Genotoxic Stress Induced by Alkylating Chemotherapeutics -- 4.9 BfR Risk Assessment of Alkaloids as Ingredients and Contaminants of Food: Quinine, Opium Alkaloids, and Senecio Pyrrolizidine Alkaloids -- 4.10 Elucidation of the Genotoxic Activity of the Alkaloid Ellipticine in Human Cell Lines. , 4.11 Dietary Supplements and Herbal Medicinal Products - for a Clear Differentiation. Statement of the Society for Phytotherapy (GPT) to the "Article 13 Health Claim List" of the EFSA -- 4.12 Assessment of Genotoxicity of Herbal Medicinal Preparations According to the Guideline EMEA/HMPC/107079/2007 - A Model Project of Kooperation Phytopharmaka, Bonn, Germany -- 4.13 Implications for an Adverse Effect of Vitamin C in Photodynamic Therapy -- 4.14 Using the Nematode Caenorhabditis elegans to Identify Mode of Action of the Flavonoid Myricetin -- 4.15 Low-Temperature Plasma - Mild Preservation Technology for Minimal Processed Fresh Food? -- 4.16 Influence of Fumonisin B1 on Gene Expression and Cytokine Production -- 4.17 Effects of Quercetin on the Detoxification of the Food Contaminant Benzo[a]pyrene in the Human Intestinal Caco-2 Cell Model -- 4.18 Risk Assessment of T-2 and HT-2 Toxin Using Human Cells in Primary Culture -- 4.19 Pyrrolizidine Alkaloids in Honey Bee Products -- 4.20 Identification of Molecular Determinants for Cytotoxicity of Isoliquiritigenin from Liquorice (Glycyrrhiza glabra) towards Leukemia Cell Lines -- 4.21 Functional Effects of Polyphenol Metabolites Produced by Colonic Microbiota in Colon Cells In Vitro -- 4.22 Lifelong Exposure to Isoflavones Results in a Reduced Responsivity of the Mammary Gland in Female Rats towards Oestradiol -- 4.23 Derivation of Maximum Amounts for the Addition of Functional Ingredients to Foods -- 4.24 Constituents of Ginger Induce Micronuclei in Two Mammalian Cell Systems In Vitro -- 4.25 Relative Photomutagenic Potency of Furocoumarins and Limettin -- 4.26 Degradation of Green Tea Catechins -- 4.27 Evaluation of the Cytotoxic Effects of Herbal Homeopathic Extracts in Primary Human Hepatocytes In Vitro -- 4.28 Modulation of Antioxidant Gene Expression by Apple Juice in Rats. , 4.29 Predictivity Comparison between Screening Assays for Bacterial Mutagenicity for Natural Compounds: Micro-Ames vs. Ames Fluctuation Method -- 4.30 Automated In Vitro Micronucleus Testing of Natural Compounds in Correlation with Hydrogen Peroxide -- 4.31 Permeability of Apple Polyphenols in T84 Cell Model and their Influence on Tight Junctions -- 4.32 Influence of Apple Polyphenols on Inflammatory Gene Expression -- 4.33 Diethylstilbestrol-Like Effects of Genistein on Gene Expression of Wnt-Signalling Components in the Endometrial Ishikawa Cell Line -- 4.34 Effect of Dietary Flavonoids in Different Cell Lines: Comparison of Uptake, Modulation of Oxidative Stress and Cytotoxic Effects -- 4.35 Risk…Benefit Considerations of Isoflavone Supplements in the Treatment of Menopausal Vasomotor Symptoms -- 4.36 Effect of Different Catechins on the Growth of HT-29 Cells -- 4.37 Determination of the Isoflavone Content of Soy-Based Infant Formula of the German Market Using a Box-Behnken Experimental Design for Optimizing the Analytical Conditions -- 5 Appendix -- Participants of the Symposium Risk Assessment of Phytochemicals in Food - Novel Approaches -- Members of the DFG Senate Commission on Food Safety: Mandate 2007-2010.

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