In:
CHIMIA, Swiss Chemical Society, Vol. 62, No. 4 ( 2008-04-30), p. 226-
Abstract:
Isoprenoids are an essential class of natural products with a myriad of biological functions. All isoprenoids are assembled using two common five-carbon precursors, isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) that are biosynthesized via two completely independent routes: the mevalonate and the non-mevalonate pathway. While the former is used by humans, the latter is employed exclusively by a number of important pathogens such as the malarial Plasmodium falciparum parasite or the tuberculosis-causing Mycobacterium tuberculosis
bacterium. Hence, the constituent enzymes are potentially very interesting drug targets in the ongoing fight against diseases, whose treatment has been complicated by the emergence of multi-drug resistance. After a short description of the biosynthetic pathway, an overview will be given on the known inhibitors of the individual enzymes.
Type of Medium:
Online Resource
ISSN:
2673-2424
,
0009-4293
DOI:
10.2533/chimia.2008.226
Language:
Unknown
Publisher:
Swiss Chemical Society
Publication Date:
2008
detail.hit.zdb_id:
2179192-2
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