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  • 1
    Online-Ressource
    Online-Ressource
    Modified theory of a microperforated panel with roughened perforations
    IOP Publishing ; 2019
    In:  EPL (Europhysics Letters) Vol. 125, No. 3 ( 2019-03-11), p. 34004-
    Details
    In: EPL (Europhysics Letters), IOP Publishing, Vol. 125, No. 3 ( 2019-03-11), p. 34004-
    Materialart: Online-Ressource
    ISSN: 1286-4854
    URL: Article
    DOI: 10.1209/0295-5075/125/34004
    Sprache: Unbekannt
    Verlag: IOP Publishing
    Publikationsdatum: 2019
    ZDB Id: 1465366-7
    ZDB Id: 165776-8
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Online-Ressource
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    Osteolectin increases bone elongation and body length by promoting growth plate chondrocyte proliferation
    Proceedings of the National Academy of Sciences ; 2023
    In:  Proceedings of the National Academy of Sciences Vol. 120, No. 22 ( 2023-05-30)
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 120, No. 22 ( 2023-05-30)
    Kurzfassung: Osteolectin is a recently identified osteogenic growth factor that binds to Integrin α11 (encoded by Itga11 ), promoting Wnt pathway activation and osteogenic differentiation by bone marrow stromal cells. While Osteolectin and Itga11 are not required for the formation of the skeleton during fetal development, they are required for the maintenance of adult bone mass. Genome-wide association studies in humans reported a single-nucleotide variant (rs182722517) 16 kb downstream of Osteolectin associated with reduced height and plasma Osteolectin levels. In this study, we tested whether Osteolectin promotes bone elongation and found that Osteolectin -deficient mice have shorter bones than those of sex-matched littermate controls. Integrin α11 deficiency in limb mesenchymal progenitors or chondrocytes reduced growth plate chondrocyte proliferation and bone elongation. Recombinant Osteolectin injections increased femur length in juvenile mice. Human bone marrow stromal cells edited to contain the rs182722517 variant produced less Osteolectin and underwent less osteogenic differentiation than that of control cells. These studies identify Osteolectin/Integrin α11 as a regulator of bone elongation and body length in mice and humans.
    Materialart: Online-Ressource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.2220159120
    RVK:
    TA 1000
    RVK:
    WA 15000
    Sprache: Englisch
    Verlag: Proceedings of the National Academy of Sciences
    Publikationsdatum: 2023
    ZDB Id: 209104-5
    ZDB Id: 1461794-8
    SSG: 11
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Online-Ressource
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    Sound absorption theory for micro-perforated panel with petal-shaped perforations
    Acoustical Society of America (ASA) ; 2020
    In:  The Journal of the Acoustical Society of America Vol. 148, No. 1 ( 2020-07-01), p. 18-24
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 148, No. 1 ( 2020-07-01), p. 18-24
    Kurzfassung: Micro-perforated panel (MPP) absorbers with circular perforations are used in many noise control applications due to their attractive wide-brand sound absorption performance. Different from a common MPP with circular perforations, a unique type of MPP absorber with petal-shaped perforations is proposed. The sound absorption theory for the MPP with petal-shaped perforations is developed by accurately considering the fluid velocity in the petal-shaped perforation hole. This theory can account for the effect of altered perforation morphology (from circular to petal) on sound absorption. Finite element simulations are performed to validate the proposed theory, with good agreement achieved. The sound absorption of MPP with petal-shaped perforations is compared with that of the traditional MPP with the same porosity. It is demonstrated that the change in hole shape significantly modifies the fluid velocity field and the flow resistivity in/of the hole, and hence the sound absorption of the proposed MPP with petal-shaped perforations can outperform that of the traditional MPP in the considered case. This work proposes a general MPP theory that not only contains the classical Maa's theory for circular MPP, but also accounts for the MPP with petal-shaped perforations.
    Materialart: Online-Ressource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/10.0001462
    RVK:
    EQ 1000
    Sprache: Englisch
    Verlag: Acoustical Society of America (ASA)
    Publikationsdatum: 2020
    ZDB Id: 1461063-2
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    Online-Ressource
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    Half-precessional cycle of thermocline temperature in the western equatorial Pacific and its bihemispheric dynamics
    Proceedings of the National Academy of Sciences ; 2020
    In:  Proceedings of the National Academy of Sciences Vol. 117, No. 13 ( 2020-03-31), p. 7044-7051
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 117, No. 13 ( 2020-03-31), p. 7044-7051
    Kurzfassung: The El Niño−Southern Oscillation (ENSO), which is tightly coupled to the equatorial thermocline in the Pacific, is the dominant source of interannual climate variability, but its long-term evolution in response to climate change remains highly uncertain. This study uses Mg/Ca in planktonic foraminiferal shells to reconstruct sea surface and thermocline water temperatures (SST and TWT) for the past 142 ky in a western equatorial Pacific (WEP) core MD01-2386. Unlike the dominant 100-ky glacial−interglacial cycle recorded by SST and δ 18 O, which echoes the pattern seen in other WEP sites, the upper ocean thermal gradient shows a clear half-precessional (9.4 ky or 12.7 ky) cycle as indicated by the reconstructed and simulated temperature (ΔT) and δ 18 O differences between the surface and thermocline waters. This phenomenon is attributed to the interplay of subtropical-to-tropical thermocline anomalies forced by the antiphased meridional insolation gradients in the two hemispheres at the precessional band. In particular, the TWT shows greater variability than SST, and dominates the ΔT changes which couple with the west−east SST difference in the equatorial Pacific at the half-precessional band, implying a decisive role of the tropical thermocline in orbital-scale climate change.
    Materialart: Online-Ressource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.1915510117
    RVK:
    TA 1000
    RVK:
    WA 15000
    Sprache: Englisch
    Verlag: Proceedings of the National Academy of Sciences
    Publikationsdatum: 2020
    ZDB Id: 209104-5
    ZDB Id: 1461794-8
    SSG: 11
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
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    Proline hydroxylation of CREB-regulated transcriptional coactivator 2 controls hepatic glucose metabolism
    Proceedings of the National Academy of Sciences ; 2023
    In:  Proceedings of the National Academy of Sciences Vol. 120, No. 23 ( 2023-06-06)
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 120, No. 23 ( 2023-06-06)
    Kurzfassung: Prolyl hydroxylase domain (PHD) enzymes change HIF activity according to oxygen signal; whether it is regulated by other physiological conditions remains largely unknown. Here, we report that PHD3 is induced by fasting and regulates hepatic gluconeogenesis through interaction and hydroxylation of CRTC2. Pro129 and Pro615 hydroxylation of CRTC2 following PHD3 activation is necessary for its association with cAMP-response element binding protein (CREB) and nuclear translocation, and enhanced binding to promoters of gluconeogenic genes by fasting or forskolin. CRTC2 hydroxylation–stimulated gluconeogenic gene expression is independent of SIK-mediated phosphorylation of CRTC2. Liver-specific knockout of PHD3 (PHD3 LKO) or prolyl hydroxylase–deficient knockin mice (PHD3 KI) show attenuated fasting gluconeogenic genes, glycemia, and hepatic capacity to produce glucose during fasting or fed with high-fat, high-sucrose diet. Importantly, Pro615 hydroxylation of CRTC2 by PHD3 is increased in livers of fasted mice, diet-induced insulin resistance or genetically obese ob/ob mice, and humans with diabetes. These findings increase our understanding of molecular mechanisms linking protein hydroxylation to gluconeogenesis and may offer therapeutic potential for treating excessive gluconeogenesis, hyperglycemia, and type 2 diabetes.
    Materialart: Online-Ressource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.2219419120
    RVK:
    TA 1000
    RVK:
    WA 15000
    Sprache: Englisch
    Verlag: Proceedings of the National Academy of Sciences
    Publikationsdatum: 2023
    ZDB Id: 209104-5
    ZDB Id: 1461794-8
    SSG: 11
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
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    Atmospheric forcing dominates winter Barents-Kara sea ice variability on interannual to decadal time scales
    Proceedings of the National Academy of Sciences ; 2022
    In:  Proceedings of the National Academy of Sciences Vol. 119, No. 36 ( 2022-09-06)
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 119, No. 36 ( 2022-09-06)
    Kurzfassung: The last two decades have seen a dramatic decline and strong year-to-year variability in Arctic winter sea ice, especially in the Barents-Kara Sea (BKS), changes that have been linked to extreme midlatitude weather and climate. It has been suggested that these changes in winter sea ice arise largely from a combined effect of oceanic and atmospheric processes, but the relative importance of these processes is not well established. Here, we explore the role of atmospheric circulation patterns on BKS winter sea ice variability and trends using observations and climate model simulations. We find that BKS winter sea ice variability is primarily driven by a strong anticyclonic anomaly over the region, which explains more than 50% of the interannual variability in BKS sea-ice concentration (SIC). Recent intensification of the anticyclonic anomaly has warmed and moistened the lower atmosphere in the BKS by poleward transport of moist-static energy and local processes, resulting in an increase in downwelling longwave radiation. Our results demonstrate that the observed BKS winter sea-ice variability is primarily driven by atmospheric, rather than oceanic, processes and suggest a persistent role of atmospheric forcing in future Arctic winter sea ice loss.
    Materialart: Online-Ressource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.2120770119
    RVK:
    TA 1000
    RVK:
    WA 15000
    Sprache: Englisch
    Verlag: Proceedings of the National Academy of Sciences
    Publikationsdatum: 2022
    ZDB Id: 209104-5
    ZDB Id: 1461794-8
    SSG: 11
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
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    RAS1, a quantitative trait locus for salt tolerance and ABA sensitivity in Arabidopsis
    Proceedings of the National Academy of Sciences ; 2010
    In:  Proceedings of the National Academy of Sciences Vol. 107, No. 12 ( 2010-03-23), p. 5669-5674
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 107, No. 12 ( 2010-03-23), p. 5669-5674
    Kurzfassung: Soil salinity limits agricultural production and is a major obstacle for feeding the growing world population. We used natural genetic variation in salt tolerance among different Arabidopsis accessions to map a major quantitative trait locus (QTL) for salt tolerance and abscisic acid (ABA) sensitivity during seed germination and early seedling growth. A recombinant inbred population derived from Landsberg erecta (L er ; salt and ABA sensitive) × Shakdara (Sha; salt and ABA resistant) was used for QTL mapping. High-resolution mapping and cloning of this QTL, Response to ABA and Salt 1 (RAS1 ), revealed that it is an ABA- and salt stress-inducible gene and encodes a previously undescribed plant-specific protein. A premature stop codon results in a truncated RAS1 protein in Sha. Reducing the expression of RAS1 by transfer-DNA insertion in Col or RNA interference in L er leads to decreased salt and ABA sensitivity, whereas overexpression of the L er allele but not the Sha allele causes increased salt and ABA sensitivity. Our results suggest that RAS1 functions as a negative regulator of salt tolerance during seed germination and early seedling growth by enhancing ABA sensitivity and that its loss of function contributes to the increased salt tolerance of Sha.
    Materialart: Online-Ressource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.0910798107
    RVK:
    TA 1000
    RVK:
    WA 15000
    Sprache: Englisch
    Verlag: Proceedings of the National Academy of Sciences
    Publikationsdatum: 2010
    ZDB Id: 209104-5
    ZDB Id: 1461794-8
    SSG: 11
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
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    Crucial role of copper in detection of metal-coordinating odorants
    Proceedings of the National Academy of Sciences ; 2012
    In:  Proceedings of the National Academy of Sciences Vol. 109, No. 9 ( 2012-02-28), p. 3492-3497
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 109, No. 9 ( 2012-02-28), p. 3492-3497
    Kurzfassung: Odorant receptors (ORs) in olfactory sensory neurons (OSNs) mediate detection of volatile odorants. Divalent sulfur compounds, such as thiols and thioethers, are extremely potent odorants. We identify a mouse OR, MOR244-3, robustly responding to (methylthio)methanethiol (MeSCH 2 SH; MTMT) in heterologous cells. Found specifically in male mouse urine, strong-smelling MTMT [human threshold 100 parts per billion (ppb)] is a semiochemical that attracts female mice. Nonadjacent thiol and thioether groups in MTMT suggest involvement of a chelated metal complex in MOR244-3 activation. Metal ion involvement in thiol–OR interactions was previously proposed, but whether these ions change thiol-mediated OR activation remained unknown. We show that copper ion among all metal ions tested is required for robust activation of MOR244-3 toward ppb levels of MTMT, structurally related sulfur compounds, and other metal-coordinating odorants (e.g., strong-smelling trans -cyclooctene) among 〉 125 compounds tested. Copper chelator (tetraethylenepentamine, TEPA) addition abolishes the response of MOR244-3 to MTMT. Histidine 105, located in the third transmembrane domain near the extracellular side, is proposed to serve as a copper-coordinating residue mediating interaction with the MTMT–copper complex. Electrophysiological recordings of the OSNs in the septal organ, abundantly expressing MOR244-3, revealed neurons responding to MTMT. Addition of copper ion and chelator TEPA respectively enhanced and reduced the response of some MTMT-responding neurons, demonstrating the physiological relevance of copper ion in olfaction. In a behavioral context, an olfactory discrimination assay showed that mice injected with TEPA failed to discriminate MTMT. This report establishes the role of metal ions in mammalian odor detection by ORs.
    Materialart: Online-Ressource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.1111297109
    RVK:
    TA 1000
    RVK:
    WA 15000
    Sprache: Englisch
    Verlag: Proceedings of the National Academy of Sciences
    Publikationsdatum: 2012
    ZDB Id: 209104-5
    ZDB Id: 1461794-8
    SSG: 11
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
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    Heterochromatin remodeling by CDK12 contributes to learning in Drosophila
    Proceedings of the National Academy of Sciences ; 2015
    In:  Proceedings of the National Academy of Sciences Vol. 112, No. 45 ( 2015-11-10), p. 13988-13993
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 112, No. 45 ( 2015-11-10), p. 13988-13993
    Kurzfassung: Dynamic regulation of chromatin structure is required to modulate the transcription of genes in eukaryotes. However, the factors that contribute to the plasticity of heterochromatin structure are elusive. Here, we report that cyclin-dependent kinase 12 (CDK12), a transcription elongation-associated RNA polymerase II (RNAPII) kinase, antagonizes heterochromatin enrichment in Drosophila chromosomes. Notably, loss of CDK12 induces the ectopic accumulation of heterochromatin protein 1 (HP1) on euchromatic arms, with a prominent enrichment on the X chromosome. Furthermore, ChIP and sequencing analysis reveals that the heterochromatin enrichment on the X chromosome mainly occurs within long genes involved in neuronal functions. Consequently, heterochromatin enrichment reduces the transcription of neuronal genes in the adult brain and results in a defect in Drosophila courtship learning. Taken together, these results define a previously unidentified role of CDK12 in controlling the epigenetic transition between euchromatin and heterochromatin and suggest a chromatin regulatory mechanism in neuronal behaviors.
    Materialart: Online-Ressource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.1502943112
    RVK:
    TA 1000
    RVK:
    WA 15000
    Sprache: Englisch
    Verlag: Proceedings of the National Academy of Sciences
    Publikationsdatum: 2015
    ZDB Id: 209104-5
    ZDB Id: 1461794-8
    SSG: 11
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
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    Pacific North American circulation pattern links external forcing and North American hydroclimatic change over the past millennium
    Proceedings of the National Academy of Sciences ; 2017
    In:  Proceedings of the National Academy of Sciences Vol. 114, No. 13 ( 2017-03-28), p. 3340-3345
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 114, No. 13 ( 2017-03-28), p. 3340-3345
    Kurzfassung: Land and sea surface temperatures, precipitation, and storm tracks in North America and the North Pacific are controlled to a large degree by atmospheric variability associated with the Pacific North American (PNA) pattern. The modern instrumental record indicates a trend toward a positive PNA phase in recent decades, which has led to accelerated warming and snowpack decline in northwestern North America. The brevity of the instrumental record, however, limits our understanding of long-term PNA variability and its directional or cyclic patterns. Here we develop a 937-y-long reconstruction of the winter PNA based on a network of annually resolved tree-ring proxy records across North America. The reconstruction is consistent with previous regional records in suggesting that the recent persistent positive PNA pattern is unprecedented over the past millennium, but documents patterns of decadal-scale variability that contrast with previous reconstructions. Our reconstruction shows that PNA has been strongly and consistently correlated with sea surface temperature variation, solar irradiance, and volcanic forcing over the period of record, and played a significant role in translating these forcings into decadal-to-multidecadal hydroclimate variability over North America. Climate model ensembles show limited power to predict multidecadal variation in PNA over the period of our record, raising questions about their potential to project future hydroclimatic change modulated by this circulation pattern.
    Materialart: Online-Ressource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.1618201114
    RVK:
    TA 1000
    RVK:
    WA 15000
    Sprache: Englisch
    Verlag: Proceedings of the National Academy of Sciences
    Publikationsdatum: 2017
    ZDB Id: 209104-5
    ZDB Id: 1461794-8
    SSG: 11
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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