In:
Journal of Integrative Bioinformatics, Walter de Gruyter GmbH, Vol. 15, No. 3 ( 2018-09-25)
Abstract:
Metabolic adaptation to the host environment has been recognized as an essential mechanism of pathogenicity and the growth of Mycobacterium tuberculosis ( Mtb ) in the lungs for decades. The Mtb uses CO 2 as a source of carbon during the dormant or non-replicative state. However, there is a lack of biochemical knowledge of its metabolic networks. In this study, we investigated the CO 2 fixation pathways (such as ko00710 and ko00720) most likely involved in the energy production and conversion of CO 2 in Mtb . Extensive pathway evaluation of 23 completely sequenced strains of Mtb confirmed the existence of a complete list of genes encoding the relevant enzymes of the reductive tricarboxylic acid (rTCA) cycle. This provides the evidence that an rTCA cycle may function to fix CO 2 in this bacterium. We also proposed that as CO 2 is plentiful in the lungs, inhibition of CO 2 fixation pathways (by targeting the relevant CO 2 fixation enzymes) could be used in the expansion of new drugs against the dormant Mtb . In support of the suggested hypothesis, the CO 2 fixation enzymes were confirmed as a potential drug target by analyzing a number of attributes necessary to be a good bacterial target.
Type of Medium:
Online Resource
ISSN:
1613-4516
DOI:
10.1515/jib-2017-0041
Language:
English
Publisher:
Walter de Gruyter GmbH
Publication Date:
2018
detail.hit.zdb_id:
2147212-9
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